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Tag: "insulin" at biology news

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

... immunosuppressive regimen, and achieved sustained insulin independence (median survival >140 days with one animal now at 300 days) without evidence of porcine endogenous retrovirus (PERV) dissemination. "This represents a major step forward and proves neonatal porcine islets can correct diabetes long-te...

New journal article urges use of animal serum-free media for growing live cells

...development of the world's first animal serum-free insulin assay. In addition to humane concerns, the article emphasizes the scientific advantages of serum-free cell culture. Growing cells without animal serum ensures that fewer variables are introduced into experiments, meaning that results are easily repro...

Researchers reverse juvenile diabetes in animal model

...nabled the pancreas of the mice to begin producing insulin again," said Dr. Trucco, who also is the Hillman P...in. Dr. Trucco believes that adding small doses of insulin to the dendritic cells will help guide the dendritic cells directly to the T cells. Adding the insul...

Wisconsin scientists find a way to make human collagen in the lab

..., for example, quickly alert a diabetic to falling insulin levels. Similarly, equipped with molecules to recognize specific pathogens, such a sensor could stand perpetual guard in the body and provide instant warning of invading viruses or bacteria. "We can have total control of what goes on these very thin...

Removing DNA repair gene causes metabolic syndrome

... Sciences, also had enlarged, fatty yellow livers, insulin levels four times higher than normal, elevated lev...including obesity, hypertension, high cholesterol, insulin resistance and kidney disease. "So if there are catalytically compromised forms of NEIL1 within the...

For the first time: Longevity modulated without disrupting life-sustaining function

... the insulin/IGF-1 pathway since it is prompted by insulin and the closely related insulin-like growth factor...ulin-like signal. "If you were to interfere with insulin signaling in humans in order to prolong life, you would induce diabetes right away," cautioned gradu...

Hap1 protein links circulating insulin to brain circuits that regulate feeding behavior in mice

...pothalamus, serves as the link between circulating insulin in the blood and the neural circuitry that control...e food intake and energy balance. Hormones such as insulin and leptin, which circulate in the blood plasma, are known to play an important role in regulating t...

Thinner and younger

...triction reduces two key markers of aging: fasting insulin levels and body temperature. More than a decade ...estriction diet ended the study with lower fasting insulin levels and lower core body temperatures. They also had less oxidative damage to their DNA, thought t...

Traditional Chinese medicine for diabetes has scientific backing

...involved in improving sensitivity of the tissue to insulin ?this in turn helps lower blood sugar levels. In addition, it seems berberine can help reduce body weight". Current medicines for treating type 2 diabetes include metformin and the TZD group of drugs. However, alarge number of patients cannot toler...

One-third of adults with diabetes still don't know they have it

... levels of blood glucose resulting from defects in insulin production, insulin action, or both. It is the most common cause of blindness, kidney failure, and amputations in adult...

Chewing up a key regulator of fat synthesis keeps mice lean despite a high-fat diet

...sease, a serious problem in obese individuals with insulin resistance," says Montminy. Our body's ability to...ce known as "metabolic syndrome." Most people with insulin resistance will develop type 2 diabetes within 10 years, unless they lose 5 to 7 percent of their bo...

Toxic molecule may cause most common type of muscular dystrophy

...of the muscles, irregular heartbeat, cataracts and insulin resistance. Many people don't know they have MMD until their teens or twenties. To prove the theory that toxic RNA is involved in myotonic muscular dystrophy, a research team led by Dr. Mani Mahadevan, a UVa pathologist, duplicated the disease i...

Teasing out tissue from blood

...ytes into pancreatic islet-like cells that produce insulin in response to high levels of glucose. "We now want to transplant these cultures into a diabetic mouse model," says Winnier, adding their results are being prepared for publication in a peer-reviewed journal. Alan Colman of ES International, a compa...

The molecular mechanism of a diabetes vaccine revealed

...ucing and ultimately eliminating the production of insulin ?a hormone needed to convert sugar, starches, and other foods into energy. Several years ago, Prof. Cohen and colleagues developed a vaccine that arrests the progression of Type 1 diabetes in laboratory animals. They had discovered that a particular...

Successful transplantation from pig embryos to mice

...face a lifetime of daily injections to replace the insulin their bodies fail to produce, as well as a host of...tes, transplants of the pancreatic tissue in which insulin is produced might alleviate these problems. Unfortunately, there are not nearly enough organ donors ...

Compound in dairy products targets diabetes

...ults indicated that the mice had an improvement in insulin action, and a decrease in circulating glucose. Als... 8 weeks, CLA improves the body's misregulation of insulin and lowers the level of glucose in the blood in patients with adult onset, or Type-2 diabetes, the m...

Joslin discovers signs of residual islet cell function in people with long-term type 1 diabetes

...edalists still have c-peptide secretion, a sign of insulin production, and some are positive for antibodies t... 125 people with type 1 diabetes for biomarkers of insulin function. Of this group, 12.7 percent had a c-peptide level greater than 0.3 ng/mL, which indicates ...

Bacteria have their own immune system protecting against outside DNA

...for medicine and research. These proteins, such as insulin or human growth hormone, are created when a piece of human DNA corresponding to that protein is introduced into bacteria. The bacteria then reproduce many times over, creating more of the protein each time they reproduce. The proteins are purified ou...

Diabetes research takes wing thanks to long-lived fruit fly

...at responds to stress and works in tandem with the insulin receptor that is central to diabetes. They recentl...JNK targets the same protein as the widely studied insulin receptor, central to human health and to the disease process that underlies diabetes. The finding ha...

Gardenia fruit compound starting point for diabetes therapy

...body's main energy source. In those with diabetes, insulin deficiency or insulin resistance causes blood sugar concentrations to rise. The team discovered that Gardenia extract con...

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