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Tag: "insulin" at biology news

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...irs the pancreas's ability to later secrete enough insulin in response to blood glucose. "The bottom line is...e 1 diabetes, the pancreas cannot make the hormone insulin at all; about 1 million Americans must control this form by taking insulin injections. In type 2 -- ...

Research on Worms Yields Clues on Aging

...nsory inputs fromthe outside regulate the level of insulin signaling inside the body,which then in turn regul...eir influence on the neural system involved in the insulin signalingpathway and partly through an independent mechanism, according toKornfeld."Our experiments ...

FDA Approves New Drug to Treat Type I and Type II Diabetes

...pe 2 diabetes. Symlin is to be used in addition to insulin therapy in patients who cannot achieve adequate control of their blood sugars on intensive insulin therapy alone. Symlin will be the only therapy for the treatment of type 1 diabetes other than insu...

PCRM develops world's first cruelty-free insulin assay

... PCRM has developed the world's first cruelty-free insulin assay, a test used to measure insulin levels in individuals with diabetes. The assay, which uses no animals, was developed as part of PCRM...

Chemists identify key gene in development of type 1 diabetes

...people, particularly children, avoid a lifetime of insulin injections, Al-Abed says. Prediabetic individuals are those who have blood markers ?either antibodies or genetic markers ?that are predictive of the disease but are still able to produce insulin. Al-Abed and his associates hope that the experimental...

Towards precise classification of cancers based on robust gene functional expression profiles

...people, particularly children, avoid a lifetime of insulin injections, Al-Abed says. Prediabetic individuals are those who have blood markers ?either antibodies or genetic markers ?that are predictive of the disease but are still able to produce insulin. Al-Abed and his associates hope that the experimental...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...daughter. The transplanted islets began producing insulin within minutes, explains Dr. Shapiro. "The reason I'm so excited about this is because normally the Edmonton Protocol is done with islets from brain-dead organ donors. Those islets are often severely injured from cold storage, transport time and the ...

Stem cells from brain transformed to produce insulin at Stanford

...nsects such as fruit flies, the cells that produce insulin and regulate blood sugar are, in fact, neurons. Ta...result was a dish full of cells that could produce insulin and release it in response to sugar added to the environment. These cells don't perfectly mimic hum...

Rare surgery performed to remove pancreas, prevent diabetes

...ients without functioning islet cells have to take insulin for life. Retrieving and relocating the natural insulin-producing cells from the pancreas saves patients from the complications of severe, poorly-controlled diabetes. Loss of the other major function of the pancreas, production of digestive enzymes, ...

Genetic defects give the immune system the green light to attack the pancreas

...t food into energy. To sustain life, they must get insulin through injections. The disorder can emerge in childhood, adolescence and even appear in adulthood, but the genetic stage is set beforehand. T-cells play a key role. They are part of the highly complex array of immune cells that normally work togeth...

NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells

...iscovered the critical sequence of events by which insulin stimulates the entry of glucose into fat cells. T...which cells have difficulty using insulin, such as insulin resistance and type 2 diabetes,?said NICHD Director Duane Alexander, M.D. Glucose, a simple sugar, ...

Mouse with designer liver has enhanced glucose tolerance, insulin response

...reated a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings ... proteins. IRS proteins relay signals initiated by insulin receptors and thus play a critical role in insulin regulation inside cells. Biochemical studies on G...

Thai spice helps cut blood sugar swings

...strongly delays post-meal glucose levels, reducing insulin output In the study, rats were administered HCA p...herwise would require the body to produce a lot of insulin to deal with the 'meal.' "Finding this delayed absorption is a completely new phenomenon and one th...

Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes

... transplantation from a single donor pancreas were insulin independent one year later, according to a study i...cle. The success rate of islet (cells that produce insulin to control blood sugar levels) transplants has recently been increased markedly by transplanting a h...

Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

...the primordia mature, they replace the missing rat insulin with pig insulin, returning the rats' blood glucos...a. Even the endocrine part of the pancreas, where insulin is made, is different. "There are no structures similar to the islets of Langerhans, only individua...

Research may provide new link between soft drinks and weight gain

...n the regulation of body weight, including leptin, insulin and ghrelin, do not respond to fructose as they do to other types of carbohydrates, such as glucose. Based on that study and their new data, the researchers now also believe that another factor contributing to the increased fat storage is that the l...

Hopkins AIDS experts issue warning about global efforts to provide drug therapies

... if not cure then-fatal diseases: the discovery of insulin for diabetes in 1922 and the mass distribution of the antibiotic penicillin in 1943. In the case of diabetes, insulin's availability turned a once-fatal disease into a chronic, manageable, lifelong one, like antiretroviral therapy has done for HIV. ...

Novel live reporting system to track cells

...s that used to reactivate the body's production of insulin in the treatment of diabetes, because the genes can be "tagged" prior to injection. Therapeutic genes can then be tracked by MRI to ensure the target is reached and the desired activations occur. Prof. Neeman: "The use of ferritin as a reporter gene ...

Study: Well-known protein helps stem cells become secretory cells

...pancreatic cells that normally produce and secrete insulin don't work, and stem cells might be able to help fix that problem, the researchers note. "The key is knowing how pancreatic cells know what hormones to produce and release, or how any gland does, and the new findings add to that knowledge," says Debo...

Researchers identify new genes that regulate aging

...red affect a wide variety of activities, including insulin signaling, metabolism, and dietary regulation. Genes involved in insulin signaling are particularly interesting because corresponding human genes could potentially play a ro...

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