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Tag: "instability" at biology news

Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks

...obb Krumlauf, Ph.D., Scientific Director. "Genomic instability and gross chromosomal rearrangements are a hallmar... of chromosome end protection can initiate genomic instability through bridge-breakage-fusion cycles. It is, therefore, very important to understand the mechanism ...

CSHL research ties harmless viruses to cancer

... that have been considered harmless to chromosomal instability (CIN) and cancer. "If the model that we propose is correct, protecting the body against viruses, or preventing the cell fusion that they cause may decrease the frequency of cancers and prevent their progression," said CSHL’s lead investigator Yuri L...

Cracking the egg

... pathway. But at the same time there's evidence of instability in other areas. According to Dr. Evsikov, "There's tantalizing evidence for rapid change in a few critical mammalian genes specifically expressed in eggs. These fast-paced changes may pinpoint the molecular mechanisms for reproductive isolation, a ...

Regulating the nuclear architecture of the cell

...chromatin could be one cause of the rampant genome instability observed in cancer. Beyond these specific pathways, we're interested in the larger question of how such pathways affect the organization of the chromosomes in the cell nucleus." ...

Mutant mouse provides insights into breast cancer

...d increase in a hallmark for cancer called genomic instability -- a blanket term for an elevation in the number o...ancers, by the time you look at them, have genomic instability in some form or another," said John Schimenti, a genetics professor in Cornell's Departments of Biom...

OHSU study says stem cell 'fusion' occurs in tumors

... is one explanation for how tumors acquire genetic instability and have the potential to give rise to malignant cancer. One promising result could be in better understanding the careful balance between rapid and effective regeneration after tissue injury, and minimizing the risk of cancer. This balance can be e...

The shape of life: research sheds light on how cells take shape

...olved the mystery. Chemical bonding and mechanical instability were responsible for the stripes. In the first stage of the process, the microtubules line up uniformly, like pickets in a fence. As the microtubules continue to grow, they clump together in bundles of 200 to 300. Then these bundles buckle. Valles ...

Tiny airborne particles are a major cause of climate change

... atmosphere. This combination prevents atmospheric instability ?the condition needed to form clouds and rain. A stable atmosphere means fewer clouds; fewer clouds mean less reflection of sunlight; less reflection of sunlight and absorption of radiation lead to warming. Policy makers have argued that, in the bo...

'Signature' of chromosome instability predicts cancer outcomes

...port that a genetic profile indicating chromosomal instability -- an increased tendency to develop chromosomal ab...urnal Nature Genetics on August 20. "Chromosomal instability is one of the key mechanisms that keeps malignant cell proliferation going," says Zoltan Szallasi, M...

Cigarette smoke blocks cell repair mechanism, University of Florida study shows

...genome and causes genomic instability, and genomic instability can bring about several cellular dysfunctions, and...ffected. Only a single cell which may have genomic instability due to compromised DNA repair capacity of the cell can be sufficient for a tumor to develop. That ha...

Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease

...n sudden death. Over a patient's lifetime, chronic instability of blood amino acids can result in serious learning disabilities and mental illness. Before transplant, the only treatment was strict adherence to a diet almost devoid of protein. Despite adherence to this diet, patients were still at risk of metabo...

When good DNA goes bad

...e called Z-DNA, it can lead to the kind of genetic instability associated with cancers such as leukemia and lymph...d of inquiry into the role of DNA shape in genomic instability and cancer." Imagine untwisting the DNA ladder and then winding it up the other way. The result is ...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

... response pathway makes the gene unstable. Genomic instability is the driving force in tumor formation, which is why cancer researchers around the world are focusing on understanding the DNA damage response pathway. Knowing how the cell communicates DNA injury to alert the repair system is an important first ste...

Double trouble: Cells with duplicate genomes can trigger tumors

...of the cancer-triggering process. Once the genetic instability sets in, tumors "evolve " by losing, gaining and r...atise suggesting, among other things, that genetic instability was a cause of malignant tumors. One way to obtain this lack of chromosomal integrity, Boveri prop...

World-first technology enables study of ancient bacteria

...the Bermuda Triangle becomes unstable; this causes instability of the sea and an explosive mixture of air and methane above. Any ships or planes travelling over the area could sink or catch fire. "So ancient, deep-sediment bacteria may be a key to sustainable energy in the future and to explaining a few disaste...

Important discovery about second most fatal cancer

... many genes) # Frequent but variable levels of DNA instability across different colorectal cancers occurring in members of same family # Origin in serrated polyps (considered previously to be completely benign) Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in the...

Disease progression model of pancreatic cancer developed by Penn researchers

... researchers established the occurrence of genomic instability in the mouse model. Genomic instability–continuous...tic changes throughout the affected cells. Genomic instability is seen in many human epithelial cancers, including pancreatic cancer, and is thought to be a drivin...

Insight into DNA's 'weakest links' may yield clues to cancer biology

... sites, providing new insight into the chromosomal instability found in cancer cells, said the researchers. "If ...uke. "Now, we have been able to mimic some of that instability in yeast cells and can begin to ask whether there is anything special that defines those places wher...

Cooperation is key—a new way of looking at MicroRNA and how it controls gene expression

... unstable and prone to degradation. This inherent instability is built into the 3' tail of the mRNA in the form of noncoding stretches of RNA called AU-rich elements. Lots of genes, including inflammatory cytokines and cancer-causing oncogenes, have these AU-rich elements built in. AU-rich element degradation ...

Yeast Network Prevents Damage By Oxygen Radicals

...results suggest that endogenous ROS-induced genome instability may contribute to cancer progression," says Dr. Kolodner, professor of medicine with UCSD School of Medicine and member of the Rebecca and John Moores UCSD Cancer Center. "And increased ROS is almost certainly more harmful in cells with acquired muta...

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