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Tag: "insight" at biology news

Attacking cancer's sweet tooth is effective strategy against tumors

...ffect in reverse. "The findings provide us with an insight into a mechanism that had been suspected in the last six or seven decades," said Leder, John Emory Andrus professor and chair of the Department of Genetics at HMS. Knocking out the glycolytic pathway could deliver a big blow to tumor cells. "LDHA c...

AIDS-related cognitive impairment exists in two separate forms

...rmal versus cancerous colon tissues should provide insight into mechanisms of colon cancer development and identify novel drugs to treat the disease" he said. Expression Profiles of 16 Genes Predict Prostate Carcinoma Relapse and Disease Free Survival in Formalin-Fixed, Paraffin-Embedded (FFPE) Benign and ...

Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers

...rmal versus cancerous colon tissues should provide insight into mechanisms of colon cancer development and identify novel drugs to treat the disease" he said. Expression Profiles of 16 Genes Predict Prostate Carcinoma Relapse and Disease Free Survival in Formalin-Fixed, Paraffin-Embedded (FFPE) Benign and ...

Mutation in blood stem cells provides clues to cancer development

...ate the disease." The research also provides more insight into why some patients develop leukemia or other malignancies, while others don't, by identifying determinant cancer genes and the signaling pathways leading to the disease. "It will tell us more about cancer and how cancer progresses," Jamieson add...

Man-made heart tissue improves cardiac performance

... well as in the use of drug development to provide insight into cardiac developmental biology. ...

Common molecular 'signature' identified in solid tumors

...mote malignant growth. The finding provides more insight into miRNA as an emerging class of gene regulators and may also pave the way for new approaches in diagnosis and treatment. The study appears online in the Proceedings of the National Academy of Sciences. Scientists have only recently begun to un...

Inside rocks, implications for finding life on Mars

...rganic geochemist. "It's very difficult to get any insight about the biochemistry of organisms that lived nearly a billion years ago, and this (confocal microscopy and Raman spectroscopy) gives it to you. You see the cells in the confocal microscopy, and the Raman spectroscopy gives you the chemistry. "We c...

Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

...ties of the heart have used the tissue to gain new insight into the mechanisms that spawn irregular heart rhythms. Studies of the engineered cardiac tissue revealed that while electric shocks such as those delivered by defibrillators usually stopped aberrant waves, in some cases they cause them to accelerate...

Stowers scientists demonstrate mechanism of vertebral formation

...heir function in embryonic development may provide insight into their dysfunction in cancer. Additional contributing authors from the Stowers Institute include Pascale Malapert, Lab Manager II; Jérome Chal, Predoctoral Research Associate; Gonçalo Vilhais-Neto, Predoctoral Research Fellow; Miguel Maroto, Ph...

ASU researchers find link between social behavior, maternal traits in bees

...is for social living and divisions of labor. This insight provides evidence for how complex social behavior ...nce social behavior in one system, we can use this insight to create a more general model. Once we have a general model, we can build new hypotheses that outli...

Statins have neutral effect on risk of cancer

...ollection of cancer data in a majority of studies, insight into the risk of cancer among statin-naïve persons and statin users can be derived," the authors write. C. Michael White, Pharm.D., from the University of Connecticut and Hartford Hospital, Hartford, Conn., and colleagues, conducted a search of the ...

Genome changes tracked during multiple myeloma initiation, progression and treatment

...hough genetic screening studies have provided some insight into the pathogenesis that underlies MM, the full landscape of genomic events driving cancer initiation, progression, and response to treatment have remained hidden from view. Drs. Ron A. DePinho from the Dana-Farber Cancer Institute, Cameron Brennan...

Study reveals classic symbiotic relationship between ants, bacteria

...a and the antibiotics they produce. He made a key insight that white spots on the ants, which were previously dismissed as "waxy blooms," were actually colonies of bacteria. In the latest phase of his research, Currie, who began this study when he was at the University of Kansas, and his team removed the e...

How sperm crack the whip

...d to the egg, he said. Such research could yield insight into some male infertility, said Clapham. Still-unidentified mutations in any of the four CatSper proteins ?all of which are involved in motility ?could underlie some forms of infertility, he said. "Also, these proteins are good targets for contrac...

Molecular mechanism may explain how fevers spark seizures

...l defects of the mutant GABA-A receptors, offering insight into the mechanisms underlying those epilepsies. One of the common features in the families with mutations in the GABA-A receptor gamma subunit -- one of several protein "parts" that come together to make a functional receptor -- is a history of fe...

Measuring artery repair cells could become new heart disease test

...d repair, and now we may have a test that gives us insight into the repair portion of the equation." "If the results of this study are borne out, measuring EPCs could be a better test for defining an individual patient's risk for heart disease," Povsic said. "Theoretically, patients who are found to have lo...

Research could lead to better drugs and whiter whites

... with colleagues in Bristol, has provided a unique insight into the working of enzymes ?biological molecules ...ntum mechanical tunnelling. "We have provided new insight into how enzymes work from painstaking efforts of a large interdisciplinary group based on detailed ...

The giant protein titin helps build muscles

..." Wilmanns concludes. "We have just started to get insight into one of the most complex systems in the human body." "This work is a nice example of how modern biology combines approaches from cell biophysics and structural biology, and it gives us a way to discover why some mutations in titin are linked to ...

Penguins waddle but they don't fall down, UH researchers say

... and length of their steps. The data will provide insight into the natural mechanics and stability of the penguins' walking patterns. Kurz is collaborating with biologists at Moody Gardens, a public, nonprofit educational destination utilizing nature in the advancement of rehabilitation, conservation, re...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

...ar ruler," Doudna explained. "It gives us a lot of insight into how the mechanism works." Dicer, which is ubiquitous in the cells of higher animals, including humans, is a widely studied molecule. It was first discovered in 2001 by Gregory J. Hannon, an HHMI investigator at Cold Spring Harbor Laboratory, an...

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