New technology used to construct the first map of structural variation in the human genome
...isms underlying the formation of CNVs also provide insight into evolutionary processes and human origins. Using microarray technology, scientists can scan for CNVs across the genome in a single experiment. While this is a cost-effective means of obtaining large amounts of data, scientists have struggled ...NASA study: Alaskan fires affected Houston air quality in 2004
... network of ground stations provided unprecedented insight into the origins of locally poor air quality in Houston on those two days," Morris said. Houston frequently exceeds federal standards for ground-level ozone. On 52 days in 2005, Houston's air quality violated the eight-hour Environmental Protection ...A new understanding of how cells defend themselves against bacterial pore-forming toxins
... attacked by bacteria and parasites and also gives insight into the more general process of cell membrane biogenesis. Bacteria and parasites often use special toxins to perforate the membranes of target cells. These pore-forming toxins are a key weapon in the attack arsenal of some common and virulent bact...Living laboratory found on shoreline statues
...lement as well as offering scientists an important insight into factors influencing colonisation. The installation of the cast iron figures - each a replica of the artist's own body, and identical in size, shape and material - offer a perfectly replicated study environment to test for the effects of dif...Squid skin reveals hidden messages
... cephalopods in natural environments would provide insight into animal camouflage mechanisms and may uncover similar examples in other species. ...Study offers window into human behavior, brain disease
...nificantly depleted. "This finding provides new insight into how frontotemporal dementia erodes the brain at the cellular level," says the first author of the study, William Seeley, MD, UCSF instructor of neurology and a clinician-scientist at the UCSF Memory and Aging Center. Progress has been made in...Most widely used organic pesticide requires help to kill
...le to perform its lethal work. The startling new insight into the workings of one of the most important and...team writes in its PNAS report. What's more, the insight that gut microbes mediate the effects of bacterial toxins could have application in human and animal...Scientists find a key to immune system's ability to remember
... to pathogens we've experienced before. The new insight is important not only because it sheds light on th...er in number and they are more potent." The new insight could help refine therapeutic targets to treat autoimmune diseases and may inform new strategies for...Molecular anatomy of influenza virus detailed
...eatures of highly virulent strains, and to provide insight into how antibodies inactivate the virus, and how viruses recognize susceptible cells and enter them in the act of infection. "Being able to visualize influenza virus particles should boost our efforts to prepare for a possible pandemic flu attack...Mother birds give a nutritional leg up to chicks with unattractive fathers
... that even ugly birds get their day. Providing new insight into the strategic basis behind resource allocation in eggs, the researchers found that female house finches deposit significantly more antioxidants, which protect the embryo during the developmental process, into eggs sired by less attractive father......tates" the subject was in, to give the researchers insight into which cortical regions were active during the states. One such cognitive state was a belief about where the subject was in the maze, and the other was a set of "operant" states. These operant states were a "proceed or update mode" or a "reevalua...A splice of the action: Translational role for WT1 isoform
...-Louise Hammarskjold (UVA) and colleagues lend new insight into the function of the Wilms' Tumor 1 tumor suppressor. The Wilms' Tumor 1 (WT1) protein is important to both normal and pathological human development, with known roles in kidney and urogenital formation as well as several human cancers. Dr. Ham...High-tech research shows cocaine changes proteins and brain function
...ent of multiple proteins in cocaine abuse provides insight into the molecular basis of the disease and offers new targets for pharmaco-therapeutic intervention for drug-abuse-related disorders, he said. "These studies are an important and significant step to further our understanding of the vast and long-t...Mutant mice show key autism traits
...he hippocampus and cortex as well as providing new insight into the molecular correlates mediating social- and anxiety-related behaviors in the postnatal CNS." ...Fly's courtship sheds light on the formation of innate behaviors
...rs in the fruit fly, researchers have provided new insight into how instinctual behaviors ?those that are not based on prior experience ?arise in the developing nervous system. The work is reported by Jean-Christophe Billeter and other members of Stephen Goodwin's group at the University of Glasgow, along wi...Study provides first look at the 'birth' of a retina cell
...ity of Michigan Kellogg Eye Center have gained new insight into the way an embryonic retina cell develops and then commits itself to a specific role. They have observed a small window of opportunity during which a cell has been designated to play a particular role, but has not yet begun to function as such. ...Potato blight pathogenicity explained by genome plasticity
... is associated with pathogenicity, and it provides insight into how plant pathogens tailor their genomes to adapt to their environments. The potato late blight pathogen, known to scientists as Phytophthora infestans , is a fungus-like organism that was responsible for the Irish Potato Famine of the 1840s a...miRNA-mediated silencing of mRNAs
...pmental Biology-Tuebingen) provide new mechanistic insight into gene silencing by miRNAs Their paper will be featured on the cover of the July 15th issue of G&D, and also will be made available online in advance on 7/3. MicroRNAs (miRNAs) are a novel class of small regulatory RNAs that silence the expr...Bacteria have their own immune system protecting against outside DNA
...essed at once. These findings give scientists new insight into how bacteria can protect themselves from an invasion by foreign DNA, yet still take in genetic information from diverse sources that makes them more virulent. "By harnessing foreign DNA, bacteria that cause typhoid, dysentery, cholera and plagu......n to Hcp1 in cystic fibrosis patients to gain more insight in the role of Hcp1 during infection. Working with cystic fibrosis patients at Children's Hospital Boston, the HMS researchers sought and found Hcp1 in the sputum of patients with P. aeruginosa. They also found Hcp1 antibodies in the patients' blo...