Genetic therapy reverses nervous system damage in animal model of inherited human disease
...ne transfer was limited to areas surrounding where injections had been made." The large animal study also demonstrated that only a limited number of injections are necessary to introduce the working LAMAN gene, one of the first steps that will prepare this par...NIAID begins clinical trial of West Nile virus vaccine
...s between the ages of 18 and 50 will receive three injections of the DNA vaccine into the upper arm: one at the start of the trial, a second approximately four weeks later, and a third approximately four weeks after that. To help force the DNA plasmid into muscle cells, the vaccine will be administered by a nee...Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma
...ver, when used over longer durations (twice-weekly injections up to four weeks), the results were striking. "Long-term treatments with this delivery system markedly inhibited tumor growth, with little or no tumor growth in many animals," said Hu. Future experiments will combine the novel delivery system with ...Turning viruses into allies against cancer
...e, or in later stages of the clinical trial, three injections separated by two to three weeks. Aside from evidence of tumor necrosis, the scientists detected expression of GM-CSF in injected tumors. "There were no obvious differences in the effects on the different tumor types," added Hu. "Following the promi...Anti cancer virotherapy well tolerated in first human administration, research finds
...ects or localised inflammation" as a result of the injections of the viral material and basic blood chemistry and liver enzyme levels remain unchanged in the these two patients. Professor Shafren told conference delegates that these findings suggested that administration of a single dose of CVA21 directly into......potential to prevent allergic reactions long after injections cease, Dr. Saxon says. However, further research and clinical testing would be required before it might be used in humans. He also is interested in applying this approach to develop a preventive treatment for serious food allergies. ...