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Tag: "injection" at biology news

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...es.Patients in the clinical trial will be given an injection of either agrowth factor called GM-CSF (granulocyte-macrophage colony stimulatingfactor) or placebo (sterile salt water) three times a week for twoweeks. The level of EPCs in the volunteers' blood will be measuredbefore, during and after administrati...

Controversial drug shown to act on brain protein to cut alcohol use

...ived Ibogaine. The drug was administered either by injection ordirectly into the same brain region where GDNF levels were shown toincrease.The research also showed that Ibogaine was quite effective inpreventing relapse, or "falling off the wagon" -- the vulnerability ofrecovered alcoholics or addicts to return...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...ell to enzyme infusions, treatment requires weekly injection of a large amount of the enzyme. "Gene therapy ha...y in Pompe disease mice. Six weeks after muscular injection with the virus containing the muscle-restricted gene, mice exhibited high levels of the enzyme and r...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

...e middle muscular layer of the heart wall near the injection site. Inside the cell, the DNA encoded VEGF-2 expresses itself which in turn stimulates the growth of new blood vessels by promoting the proliferation of endothelial cells in the heart. New blood vessels are required to provide oxygen-carrying blood...

HIV vaccine trial breaks ground for future research

...ransmission. The vaccine and placebo were given by injection seven times over 30 months and the participants were assessed for risk. At each visit the participants were tested for HIV infection, and for those who were positive, HIV-1 plasma RNA load and CD4 cell counts were monitored on a regular basis for 24 ...

Gene Therapy Cures Inherited Liver Disease In Rats

... has been completely cured long term with a single injection in an adult animal," said Dr. Brendan Lee, associate professor of molecular and human genetics and a Howard Hughes Medical Investigator at Baylor College of Medicine. Crigler-Najjar syndrome is currently treated by placing the person under special U...

First frozen egg baby born in Canada

...tro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), and the resulting embryos implanted in her uterus. "The patient went through an uncomplicated full-term pregnancy and straightforward delivery," says Dr. William Buckett, the MUHC physician who looked after the mother during the pregnancy. T...

Youth With HIV Take More Risks After New Meds Introduced

... more likely to have had a sexual partner who used injection drugs. The post-HAART group also knew their HIV diagnosis at a younger age and were in worse health than the pre-HAART group, the researchers found. "Given the availability of HAART, it is surprising that the post-HAART youth experienced more sympt...

Used in a new way, RNA interference permanently silences key breast cancer gene

...unable to form breast tumors either at the site of injection or at distant sites typically involved in metastatic breast cancer in this mouse model. Arlinghaus points out that a human therapy based on these findings is not on the horizon because lentivirus delivery systems haven't been approved for human use ...

Turning viruses into allies against cancer

... stages of their disease, received either a single injection of the virus, the volume depending on tumor size, ...venous treatment with this combination followed by injection of radioactive iodine into the mice bearing the human hepatocellular cancer cells resulted in high u...

Basis for DNA ejection from single phage particles

...to the driving force behind this poorly understood injection process, which has been proposed in the past to occur through the release of pressure accumulated within the viral particle itself. Almost all phages (also known as bacteriophages) are formed of a capsid structure, or head, in which the viral genome...

Gene therapy cures inherited liver disease in rats

... has been completely cured long term with a single injection in an adult animal," said Dr. Brendan Lee, associate professor of molecular and human genetics and a Howard Hughes Medical Investigator at Baylor College of Medicine. Crigler-Najjar syndrome is currently treated by placing the person under special U...

UCLA cancer researchers shake loose hidden biomarker

... of the cell membrane, which blood can't reach, so injection of immunotherapy into the bloodstream is not effective," said Rajasekaran, also an associate professor of pathology and laboratory medicine. "By using information from very basic studies about how the PSMA protein is targeted in these cells, we ident...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

... in rat models, also showed that a single muscular injection of the molecule, interleukin-10 (IL-10), carried in a gene delivery vector, or mechanism, could provide long-term therapeutic effects. Anupam Agarwal, M.D., director of the UAB Nephrology Research and Training Center and senior author of the report,...

High rates of sexually transmitted infections found in young drug users

..., but did not find significant differences between injection drug users and non-injection drug users. Few of th... rate of sexually transmitted infections among the injection and non-injection drug users we recruited, which indicates the extent of sexual risk behaviors among...

Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'

...oncentrated salt water solution to cause pain. The injection was made while they were having their brains scann... after the scan during which they received the jaw injection alone. Nine of the participants were classified as "high placebo responders" because they had more ...

Secrets to antibody's success against West Nile Virus surprise scientists

...to increase vulnerability to the virus, they found injection of the new antibodies could boost survival rates of mice infected with the virus to greater than 90 percent. Scientists at Macrogenics are working on the preliminary studies required before the West Nile antibody can be tested in humans. Meanwhile...

No small feat: First ever gene therapy success for muscular dystrophy achieved

...ctor was delivered locally, given by intramuscular injection to different muscles of the leg. With both approaches, muscle cells were able to assimilate and copy the genetic instructions for making mini-agrin. Once produced, the mini-agrin protein functionally took the place of the laminin alpha-2 protein by b...

Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure

...tted diseases, not only by the use of contaminated injection equipment, but also due to increased risky sexual behaviors,?says Dr. Nora D. Volkow, director of the National Institute on Drug Abuse (NIDA), National Institutes of Health, which helped support the research. “These findings show that methamphetamine...

Experimental shingles vaccine proves effective in nationwide study

... study. Half of the participants received a single injection of the zoster vaccine--a live, weakened form of varicella-zoster virus, the virus responsible for chickenpox; the other half received a placebo vaccine. Neither the researchers nor the participants knew who received vaccine and who received placebo u...

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