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Tag: "initiates" at biology news

Scientists solve structure of key protein in innate immune response

...inds to substances liberated from the bacteria and initiates the cellular defense mechanisms. In a report published in the Journal of Biological Chemistry, scientists in Korea announced their elucidation of three-dimensional structure of CD14 and showed how it is perfectly suited to bind to certain bacterial p...

Epstein-Barr virus protein crucial to its role in blood cancers

... human B cells gets a jump start, which ultimately initiates uncontrolled growth. EBV, a member of the herpesvirus family and one of the most common human viruses, plays a role in cancers such as lymphoproliferative diseases in transplant or AIDS patients, Burkitt's lymphoma, Hodgkin's lymphoma, and nasophary...

Defensins neutralize anthrax toxin

... human B cells gets a jump start, which ultimately initiates uncontrolled growth. EBV, a member of the herpesvirus family and one of the most common human viruses, plays a role in cancers such as lymphoproliferative diseases in transplant or AIDS patients, Burkitt's lymphoma, Hodgkin's lymphoma, and nasophary...

Stopping smallpox in its tracks: A new anti-viral approach

...gets the erbB-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effectiv...

Buying Time Through Hibernation on Demand

...ound to the skin allows the entry of oxygen, which initiates cell death. In healthy people, cell death subsides when a clot forms, which allows the healing process to begin. Exposing a diabetic's clot-resistant wound to an oxygen-free environment would speed the healing process. While the notion of putting a ...

U-M team recovers ancient whale in Egyptian desert

...ound to the skin allows the entry of oxygen, which initiates cell death. In healthy people, cell death subsides when a clot forms, which allows the healing process to begin. Exposing a diabetic's clot-resistant wound to an oxygen-free environment would speed the healing process. While the notion of putting a ...

Master gene controls healing of skin in fruit flies and mammals

...es--to identify grainyhead as the master gene that initiates the genetic chain reaction that results in cuticle... of the wound, suggesting that the grainyhead gene initiates the cuticle repair response after it receives an as-of-yet unidentified signal produced in cells adj...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

... by the p53 tumor suppressor protein, kicks in. It initiates the process of programmed cell death, or apoptosis, which directs the cell to commit suicide, permanently removing the damaged DNA from the organism. Since the p53 protein is able to trigger such drastic action as cellular suicide, the cells of the ...

Study Finds Moderate Hypothermia A Safe Treatment For Traumatic Brain Injury In Kids

...a safe therapeutic intervention for children. TBI initiates several metabolic processes that can exacerbate the injury. Adult research has produced evidence that hypothermia may limit some of these deleterious metabolic responses. The trial, which is the only multi-center clinical trial involving children un...

Researchers seek to discover what really happens when a virus enters the body

...esponse. And as NIH's Matzinger says, knowing what initiates an immune response will affect and, researchers hope, improve medical treatment. Bell is an associate member of the Virginia Tech ?Wake Forest University's School of Medicine School of Biomedical Engineering and Science. SBES research focuses on im...

Missing Receptor Molecule Causes Tumor Growth

...ble for receiving the signal molecule TRAIL, which initiates apoptosis in these cells. Prof. Krainer explains: "To begin with it was not evident what was missing in the signal transmission. The signal or the receptor molecule? To answer this question, we examined ten different ovarian cancer cell lines. In do...

Nanoparticles carry cancer-killing drugs into tumor cells

...ble for receiving the signal molecule TRAIL, which initiates apoptosis in these cells. Prof. Krainer explains: "To begin with it was not evident what was missing in the signal transmission. The signal or the receptor molecule? To answer this question, we examined ten different ovarian cancer cell lines. In do...

Study provides insight into cellular defenses against genetic mutation

...ioneer" round checks all new mRNAs for errors, and initiates NMD when errors are detected. A second "steady-state" round translation then directs the mass production of normal proteins based on "NMD-approved" mRNAs. Recently, Maquat's team has worked to identify the roles of proteins involved in NMD, the focu...

Science's Breakthrough of the Year: Watching evolution in action

...ologists pinned down the identity of a signal that initiates the seasonal development of flowers. Other research focused on a gene involved in stimulating flowering, and another study highlighted a surprising cache of RNA. The Nature of Neutron Stars: In 2005, new instruments yielded vivid insights into the m...

Molecule does more than slice and dice RNA

...es large strands of RNA into smaller fragments, it initiates the process of RNA interference, which can turn genes off and thereby dictate key developmental events. "The bottom line we've learned from the structure is that Dicer is a molecular ruler," Doudna explained. "It gives us a lot of insight into how t...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

...es large strands of RNA into smaller fragments, it initiates the process of RNA interference, which can turn genes off and thereby dictate key developmental events. "The bottom line we've learned from the structure is that Dicer is a molecular ruler," Doudna explained. "It gives us a lot of insight into how t...

Removing DNA repair gene causes metabolic syndrome

...sibility of then removing the damaged bases, which initiates a process by which the cell puts in a normal piece of DNA where the damaged DNA was. This happens every second of your life." After breeding several generations of NEIL1 "knock-out" mice, Lloyd's colleague and the study's lead author, Vladimir Varta...

Mayo Clinic researchers challenge sepsis theory

...." The researchers define a new "first step" that initiates the sepsis syndrome cycle. In this step, a critica...ts constraint. That's the first step that actually initiates sepsis." Research is underway to discover new therapies that could prevent, blunt or reverse the rel...

A step forward in the fight against bacterial infections

...receptor in our immune system − TLR4 − initiates a long series of reactions that bring on an inflammation, which eliminates the bacteria from our body. Of course, this chain of reactions is strictly controlled, because excessive inflammation can lead to lethal shock. Mice that are able to cope wi...

Experimental drug reverses key cognitive deficits, pathology in Alzheimer's

... signals called neurotransmitters. This triggering initiates such cellular responses as the wave of electrical excitation of a nerve impulse. As an animal model of AD, the researchers used a "triple knockout" mouse in which three key genes involved in normal brain protein processing pathways had been knocked...

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