inhibits 2 4

Tag: "inhibits" at biology news

Salk and Stanford teams join forces to reveal two paths of neurodegeneration

...e mice make a mutant protein--known as Wlds --that inhibits degeneration. But the mutant Wlds protein doesn't hamper the wiring process in developing brains. In newborn Wlds mice, axons extending from nerve cells (called RGCs) in the retina to a brain center called the superior colliculus were still undergo...

New study reveals signaling pathways required for expansion of pancreas stem cells

...antly, we found that if we inject an antibody that inhibits BMP4 into these mice, this significantly reduced the number of proliferating duct cells. We also found that in these mice inhibition of BMP4 results in an increase in the expression of a bHLH protein-dependent factor PAX6, which is required for the f...

New compound reduces stroke damage

...sed in the treatment of autoimmune diseases. FK506 inhibits T-cell activation by binding to members of the FK5...ists also synthesized a molecule that specifically inhibits FKBP38 and administered it to rats that were experiencing stroke symptoms. "We developed a lead comp...

Unique dual target specificity of kinase inhibitor key for success against cancer

Scientists have identified a new molecule that inhibits proliferation of a broad range of lethal malignant glioma cells in vitro and in vivo. The findings, published in the May issue of Cancer Cell, shed light on which PI3 kinase family members are most likely to play a role in cancer progression. This st...

New bird flu drug promises to beat the problem of resistance

...g instead. The drug physically gets in the way and inhibits the action of the enzyme. This stops the virus from spreading to new cells and helps to reduce the severity and duration of flu so that the body's own defence mechanisms, together with other medical interventions, can help aid recovery. However, ...

Transgenic goat's milk offers hope for tackling children's intestinal disease

...cent as much lysozyme as does human milk. Lysozyme inhibits the growth of bacteria by destroying the bacterial cell wall, causing the contents of the cell to leak out. Because lysozyme limits the growth of bacteria that cause intestinal infections and diarrhea, and encourages the growth of beneficial intest...

Statins stop hepatitis C virus from replicating

...sed on recent reports that one statin, lovastatin, inhibits HCV replication, researchers led by Masanori Ikeda of Okayama University in Japan, tested other statins in search of a more effective anti-HCV therapy. Using the OR6 cell culture assay system, they evaluated the anti-HCV activities of five statins: ...

Drug dials down the energy within cells, UM researchers find

...Our new work reveals the mechanism by which Bz-423 inhibits the enzyme while still allowing it to function. This is important because it suggests principles that may be useful for targeting other bioenergetic pathways. Now we have some rules that we can apply to be able to modulate the mitochondria in new way...

'LEGO-Like' building blocks to halt cell growth wins Hebrew University prize

...The binding action of the molecule to the receptor inhibits the activation of the IGF-1 protein in the cells, thus halting the cancerous growth. Through this process of "combinational chemistry," involving peptides and scaffold design, Qvit says that many different types of molecules can be built that will ...

Diabetes research takes wing thanks to long-lived fruit fly

...K counters the effects of the insulin receptor and inhibits the production of insulin, a crucial hormone that converts the food we eat into forms that the body can utilize. JNK detects stress in the environment and not only prepares the body to deal with insults from the environment, but also limits the amoun...

Study identifies substances in grapefruit juice that interact dangerously with some drugs

...ice, but not other commonly consumed fruit juices, inhibits this enzyme, allowing more of these drugs to enter the body. It was originally assumed that the ingredients responsible for drug interactions were the flavonoids that give grapefruit juice its bitter taste. The new study shows that a group of che...

Protein's role in regulating cell death sets direction for cancer research

...o Wu, and Teresa De Veyra, found that calpain also inhibits programmed cell death in response to other challenges, including some chemotherapeutic drugs. This study showed that calpain contributes to the activation of AKT and JNK, two key players in the signaling pathways that control cellular responses to ...

Interfering RNA silences genes in 'slippery' immune cells

...ticular gene. This process, called gene silencing, inhibits the gene from carrying out its function of creating a protein or another gene product. The body often uses RNAi as a defense against the action of hostile viruses. Over the past few years, biomedical researchers have been investigating how they migh...

New angiogenesis finding may help fight cancer growth

...th. Also in June, the FDA approved a compound that inhibits VEGF for treating colon cancer, the second-leading cause of cancer death in the United States. The VEGF-inhibitor reduces the formation of blood vessels, helping starve tumors. But angiogenesis regulation is a two-way street, and there are some dis...

New mechanism explains glucose effect on wakefulness

...ter and his colleagues have pinpointed how glucose inhibits neurons that are key to regulating wakefulness. In.... The researchers set out to discover how glucose inhibits a particular class of glucose-sensing neurons that produce tiny proteins called orexins, which are c...

How does a zebrafish grow a new tail?

... Wnt/Beta-catenin, impairs cell proliferation, and inhibits fin regeneration. Fish that have a mutant Wnt5b pr...study is the first to identify a gene (Wnt5b) that inhibits regeneration," said Weidinger, a former UW postdoctoral fellow who leads the Wnt Signaling in Develo...

New target for cancer therapy identified

...e have found, for the first time, the pathway that inhibits telomerase in human cells," Associate Professor Liu said. "This reveals an important mechanism for developing anti-cancer agents that mimic these proteins and thereby inhibit the production of telomerase. " ...

Intrinsic eye protein halts angiogenesis

...cornea that produces so much of this protein which inhibits angiogenesis. With that knowledge we will be closer to fighting the growth of everything from vision-obscuring blood vessels in the eye to cancers," said Jayakrishna. ...

Cigarette smoking impedes tendon-to-bone healing

...interferes with healing of bone fractures and also inhibits bone fusion processes -- many spine surgeons, for example, won't do certain operations on people who smoke because of the risk of failure. But little is known about the effects of cigarettes on tendon and ligament healing. There also are some gaps...

How brain injury leads to seizures, memory problems

...lutamate stimulates neurons to fire, while GABA(A) inhibits that activity. "When lower levels of the KCC2 transporter weaken the dentate gyrus's ability to act as a gatekeeper," said Dr. Cohen, "neurons become more excitable, and seizures can occur." In addition to its role in inhibiting seizures, the den...

1 2 3 4 5 6