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Tag: "inhibitors" at biology news

Elusive HIV shape change revealed; Key clue to how virus infects cells

...ape change," says Harrison. He notes that some HIV inhibitors already in development seem to inhibit the shape change; the new findings may help pin down how these compounds work and hasten their development into drugs. "The findings also will help us understand why it's so hard to make an HIV vaccine, and will...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

...om human enzymes, making them potential targets of inhibitors that could form the basis of new drug therapies," says TIGR President Claire M. Fraser, who supervised the Institute's role in the project. E. histolytica is a voracious predator of bacteria and shares a close relationship in the human gut with its ...

Scientists Replicate Hepatitis C Virus in Laboratory

...reen compounds with a cell-based assay to look for inhibitors of virus replication,?says Liang. “We can also apply this technique to develop model systems for other similar viruses.?/p> HCV is a small, enveloped, single-stranded RNA virus in the family Flaviviridae. HCV is a major cause of liver disease in ...

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

...should not jeopardize the availability of protease inhibitors because these drugs are too important for the succ...'s research group earlier discovered that protease inhibitors affect "pore function" of "channels" in a specific cell type they were studying. Pore function in ch...

U-M scientists find genes that control growth of common skin cancer

...nt given the current efforts to develop Hh pathway inhibitors asa means of combating human BCCs, as well as other cancers. In contrastto other cancer models where inhibition of Hh signaling leads todurable tumor regression, Dlugosz's new work raises the possibilitythat Hh pathway inhibition in BCCs, while effec...

Studies reveal methods viruses use to sidestep immune system

...to try to limit infection." Drugs called protease inhibitors currently are used to treat patients infected with... could help toward further developing the protease inhibitors and more effective therapies for hepatitis C and possibly other viral infections." A third paper, a...

Scientists discover that host cell lipids facilitate bacterial movement

...indings may also open the door to using PI3-kinase inhibitors or other agents that lower PIP2 and PIP3 levels to slow the spread of Listeria and control infection in patients who are not responding to antibiotics, although that application is a long way off, says Dr. Southwick. ...

Stopping smallpox in its tracks: A new anti-viral approach

... The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infected mice. In an accompanying commentary, Anthony Fauci and Mark Challberg from the National Institutes of Health point out that this approach "may serve to turn...

New drug shows promise as powerful anticancer agent

...easonable approach to cancer therapy is to develop inhibitors that block the function of a critical molecule that is required by a tumor cell to complete cell division," explains lead author Dr. E. Premkumar Reddy from Temple University School of Medicine. "One such molecule appears to be Plk1." Dr. Reddy and ...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

...Pharmaceutical companies have been developing iNOS inhibitors to treat sepsis," explains Dr. Hobbs. "However, it now appears as if these are ineffective in reducing the mortality associated with the disease. The identification of a pro-inflammatory role for eNOS-derived NO may provide the stimulus for further r...

Supercomputers to focus brains on AIDS dilemma

...y of the viral enzyme HIV protease, these protease inhibitors brought greatly extended life-spans to patients wh...r drugs, and protease, the target for the protease inhibitors that had proven so effective until the recent emergence of drug-resistant mutants. The new drug pos...

Scientists discover how Ebola virus infects cells

...ying. The scientists applied broad-spectrum enzyme inhibitors to mammalian cells before exposing them to Ebola v...nvestigation of the antiviral efficacy of [enzyme] inhibitors may…be warranted. The wealth of existing knowledge regarding the design and in vivo pharmacology of ...

Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs

...new pathway can now be evaluated for potential new inhibitors that might be better at controlling particular psychotic behaviors." Caron is a professor of cell biology at Duke and faculty member at the Duke Institute for Genome Sciences & Policy. Dopamine's prolonged effects might also apply to understandi...

Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief

...r? The answer lay in Piomelli's pioneering work on inhibitors that break down the brain's own marijuana-like compounds. "If we design chemicals that tweak the levels of these transmitter substances in the brain," said Piomelli, "we might be able to boost their normal effects." When rats used in Hohmann's stud...

Anthrax inhibitors identified by Burnham team

...itute's Maurizio Pellecchia, Ph.D., has identified inhibitors of the anthrax toxin, termed lethal factor ("LF") ...designing a preferred structure for small-molecule inhibitors of LF. Lead compounds were synthesized and validated as highly potent and selective against LF in vi...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...ons with pharmaceutical companies to test integrin inhibitors in cancer clinical trials at the new Moores UCSD Cancer Center. Varner's colleagues in the study included Barbara Garmy-Susini, Hui Jin, Yuhong Zhu, Rou-Jia Sung and Rosa Hwang, all of UCSD. ...

Tetanus toxin found to have therapeutic properties

...ain. The molecule is as effective as the selective inhibitors currently used, but they are more powerful, they last longer, and they are more specific. This inhibitory effect converts the molecule into what could be a drug with many uses. It would be more effective than Prozac and more effective than any drug t...

Treatments have same target, different responses for lung cancer patients with genetic mutation

...evious studies have shown that small-molecule EGFR inhibitors such as gefitinib and erlotinib (Tarceva) work by blocking signals in the intracellular domain of EGFR--between the EGFR and the cell nucleus. Additionally, many NSCLC patients with mutations in this intracellular domain of EGFR appear to benefit fro...

UIC developing drug for SARS

...llergy and Infectious Diseases to develop protease inhibitors that would block key enzymes in the SARS virus and...principal investigator. "By administering protease inhibitors early, when feverish symptoms have started, the drugs could reduce the viral load and ameliorate the...

Gaining ground in the race against antibiotic resistance

...s. The results could lead to more effective enzyme inhibitors by giving drug designers a sneak peek at the next ...ncern in the clinic." To date, there are no known inhibitors of metallo-alpha-lactamases, but directed evolution could help in their design, Vila said, by giving...

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