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Tag: "inhibition" at biology news

Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

...loid cascade, thereby leading to the prevention or inhibition of amyloid deposition and the toxic effects of Aβ peptide in the brain. About the Phase III Clinical Trials for tramiprosate (Alzhemed? Neurochem is currently conducting a multi-center, randomized, double-blind, placebo-controlled and parallel-d...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...normal balance between growth promotion and growth inhibition is disrupted. Epidermal Growth Factor (EGF) and the EGFR to which it homes and docks are a hot topic in cancer research because EGF promotes growth through binding and activating its receptor and certain tumors exhibit elevated levels of EGFR. In add...

COX-2 inhibitors significantly reduce risk of cancer

...ps in cancer development, including cell division, inhibition of cell death, angiogenesis (the creation of new blood vessels to nourish growing tumors) and metastasis," says Harris, who is also a member of the OSU Comprehensive Cancer Center. Harris says his research group is only midway through analyzing dat...

Protein found to control tumor growth in certain breast cancers

...ession of the protein resulted in the nearly total inhibition of estrogen-dependent tumor growth in mice, and th...-expression of Nod1 in MCF-7 cells resulted in the inhibition of estrogen-dependent tumor growth in the SCID mice and a reduction of estrogen-induced proliferativ...

Therapeutic prospects beyond Vioxx

...brex. They found that genetic disruption of COX-2; inhibition of the enzyme by different inhibitors; and disrupt...at deletion of mPGES-1, in contrast to deletion or inhibition of COX-2, did not predispose the animals to thrombosis or elevate blood pressure. A clue to this sur...

Researchers reveal lung's unique innate immune system

...t in which the alveolar macrophages circumvent the inhibition by TGFb for brief period of time, in order perform their immune task. This is accomplished through regulation of TGFb activity by a set of cell surface receptors, proteins called integrins. This regulation allows the alveolar macrophages to take on...

Forsyth scientists gain greater understanding of how embryos differentiate left from right

... roles for both physiological parameters. V-ATPase inhibition also abolished the normal localization of serotonin at the 16-cell stage, suggesting that it helps to regulate the early flow of this important neurotransmitter. These data implicate H+-V-ATPase activity in patterning the left right axis of three dif...

Botox could help target resistant tumors for treatment

...ents," said Gallez. "Botulinum toxin could lead to inhibition of contractions of tumor vessels, improve tumor pe...uromuscular contractions of vessels in tumors. The inhibition of this contraction could literally open the gate to improved tumor perfusion by chemotherapeutic dr...

How 'hot' emotional brain interferes with 'cool' processing

...ter activity in a brain region associated with the inhibition of response to emotional stimuli rated the emotional distracters as less distracting. Said Dolcos, "One interpretation of this finding is that, because this region is associated with inhibitory process, people who engage that region more could cope b...

Protein translation in sperm

...on of nuclear-encoded genes in sperm, and that its inhibition leads to a marked decrease in sperm motility, actin polymerization, the acrosome reaction and in vitro fertilization rates. Thus, protein translation in sperm is essential for sperm functions that directly contribute to fertilization. Dr. Breitbart...

Aggression-related gene weakens brain's impulse control circuits

...nsitivity in brain circuits important to cognitive inhibition and memory for negative emotional information may contribute to increased vulnerability of men with L exposed to abuse during childhood," suggested Weinberger. "Since only men showed gene effects in several of these circuits, this could lead to a sit...

Tiny RNA molecules fine-tune the brain's synapses

... as brain-derived neurotrophic factor (BDNF), this inhibition was overcome and Limk1 became active again, enhancing spine growth. Greenberg believes that miR-134 ?and other microRNAs his lab is studying ?may play a role in fine-tuning cognitive function by selectively controlling synapse development in respons...

Common bacteria pirate natural mechanism to get inside cells

...ection by controlling dynamin activity through the inhibition of nitric oxide synthases, enzymes that produce nitric oxide." The new research uses the common bladder infection-producing uropathogenic E. coli as a model to show how nitric oxide unwittingly assists bacterial uptake and survival. "In bladder ce...

New drug could reduce tissue damage after heart attack

...ld be possible to undertake clinical trials of CRP inhibition within a couple of years. If the treatment proves...in which CRP levels are greatly increased, and the inhibition of CRP may thus find broad application in medicine." Patents, patent applications and proprietary k...

Satellites show Amazon parks, indigenous reserves stop forest clearing

...between population density in indigenous areas and inhibition of deforestation. In much of the Amazon, not only can protecting nature be reconciled with human habitation ?it wouldn't happen without the people. Extensive intact forests on indigenous territories are central to large-scale conservation in the A...

Plants give pests sock in the gut

...at naturally expresses Mir1-CP causes a 50 percent inhibition in caterpillar growth. Transgenic black Mexican sweet corn cells that express Mir1-CP inhibit caterpillar growth by 70 percent, Luthe says. Mir1-CP is harmful to caterpillars mainly because of its damaging effect on their peritrophic matrix. This is...

Feeling old?

...hat the age-related problem results from defective inhibition of ubiquitin-proteasome dependent proteoloysis, a ...l-related stimulation of protein synthesis and the inhibition of breakdown." ...

Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer

... suggest that, if and when resistance to aromatase inhibition occurs, a strategy of treatment with estrogen ?may be sufficient to kill the cancer and control disease progression." ...

Compound from marine bacteria shows potential as multiple myeloma therapy

... from the backup of damaged proteins. "Proteasome inhibition is a key therapeutic target and bortezomib (Velcade tm) was the first in a new class of compounds in multiple myeloma. NPI-0052 is a novel proteasome inhibitor with a chemical structure and action that is distinct from bortezomib, and has the promi...

Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace

...e extent (or amplitude) of neuronal excitation and inhibition within glomeruli. He retrieved a spatial pattern of synchronized, correlated activity ?the memory trace ?from what appeared to be random fluctuations of neural activity. "The trace is like a fingerprint that disappears over time. It's strongest afte...

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