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Tag: "inhibition" at biology news

Hearts of male and female rainbow trout are different

...lactate release under resting conditions; the inhibition of oxidative metabolism with NaCN lowered cardiac ...ring working conditions and involve stimulation or inhibition of the glycolytic pathway and carbohydrate oxidation. Ultimately, sex differences in cardiac energy ...

Keeping the immune system from starting a 'food fight'

...ead to the activation of inflammatory pathways and inhibition of insulin action, resulting in systemic metabolic deterioration over the long term," he continued....

8 plants from South Africa may hold potential for treating high blood pressure

... plant extracts that exhibited over 50 percent ACE inhibition in the initial analysis. The data was subjected to...d ACEI Eight of the 16 plants demonstrated ACE inhibition activity. The plants were then subjected to a gelatin salt block test for tannins to eliminate any f...

WHO data confirms low level of resistance to Tamiflu

...us isolates collected were tested by neuraminidase inhibition assay (IC50 or sequence analysis) to detect mutations associated with drug-resistance. Results were as follows: Influenza Season in Japan No of Influenza A isolates tested Resistance No of Influenza B isolates tested Resistance 2003/2004 1...

Gut research yields new anti-cancer approach

...urther experiments showed that high-dose PPARgamma inhibition destroyed cancer cell microtubules, protein structures that form part of the skeleton of cells. Beyond providing structural support and shape to cells, microtubules expand and shrink to generate the force needed for cells to divide, a basic proces...

Aspirin discovery may improve cancer treatments

...hat investigated the effects of salicylates on the inhibition of protein synthesis. "Our research showed tha... in PERK. Thus PERK plays an important role in the inhibition of protein synthesis by salicylates. "Our research into the mechanisms by which salicylates inhi...

Scientists find hormone activity explains adolescent mood swings

... regulates emotion. Paradoxically, THP reduced the inhibition produced by these alpha4-beta2-delta GABA-A receptors, increasing brain activity to produce a state of increased anxiety. Stress also increased anxiety at puberty, due to the paradoxical effects of this hormone that is released by stress. Dr. Smi...

Anti-wrinkle compound causes pathological reaction in skin cells

... division—sometimes coming to a complete stop, the inhibition of certain metabolic reactions, and the death of a significant percentage of fibroblasts. The mortality rate of fibroblasts, which varied according to DMAE concentration, was above 25% after 24 hours in the case of a concentration similar to the one ...

Angelman syndrome deficits rescued in mice

...mouse model of Angelman syndrome by preventing the inhibition of CaMKII, an enzyme highly expressed in brain reg...reated a mouse with a mutation that prevented this inhibition of CaMKII. The researchers decided to breed the Angelman mice with the CaMKII mutant mice to see ...

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...on mice lacking the receptors had focused on fever inhibition until mice were about three months old. The team w...better understand the process by studying if fever inhibition continued later in life. When the mice were four to five months old, the researchers made a star...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...es the commanding signal from EGFR. Therefore, the inhibition of EGF receptor by cetuximab will not block the molecular signals that are activated farther down the cascade. The researchers also determined that KRAS mutations are independent of another predictive marker of cetuximab response, skin toxicity, w...

Erectile dysfunction in diabetes is due to selective defect in the brain

...rtic acid (NMDA) within the PVN. At the same time, inhibition of NO synthase with NG-monomethly-L-argining (L-NMMA) prevents NMDA-induced erection. The researchers hypothesized that the blunted NMDA mediated responses in diabetes reflects an impaired NO mechanism within the PVN. The involvement of an NO mechani...

Discovery of an HIV inhibitor in human blood points to new drug class

...lecules in human blood have been implicated in the inhibition of HIV-1, the researchers noted. However, it had remained elusive which circulating natural compounds are most effective in controlling viral replication in the body. In the new study, the researchers sifted through a comprehensive library of smal...

Small molecule dervived from Rb2/p130 could act as cancer therapeutic

...cule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo," in the March 22 issue of the journal Oncogene ( http://www.nature.com/onc ). Rb2/p130 was discovered in the early 1990s by Antonio Giordano, director of the Sbarro Institute ( ...

MIT: Pulsing light silences overactive neurons

...rol neuron firing, said Boyden. "In such diseases, inhibition is more direct than excitation, because you can sh...w exert exquisite control over the stimulation and inhibition of individual neurons. Learning more about the neural circuits involved in epilepsy could help sc...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

...in a precise ratio between neuronal excitation and inhibition that allows efficient learning. In contrast, it’s ...gests that it’s not just the removal of the excess inhibition that allows learning to occur, but that we’re instead strengthening synapses through some type of lo...

Reversing cancer cells to normal cells

...teworthy, Dr. Hendrix’s team’s also has shown that inhibition of Nodal signaling leads to a reduction in melanom...s and ability to create new tumors. In fact, with inhibition of Nodal, the metastatic melanoma cells are reverted to a more benign skin cell without the ability ...

Light wine intake is associated with longer life expectancy in men

...ol, or to a reduction in blood clotting, due to an inhibition of platelet aggregation," Streppel said. Furthermore, red wine consumption may have an additional health benefit because the polyphenolic compounds contained in wine have been seen in animal to interfere with the formation, progression and rupture ...

Novel mechanism of action of new drug for MS identified

...of Biochemistry, and lead author on the study, the inhibition of cPLA2 would shut down the entire inflammatory pathway, possibly without the side-effects caused by medications such as Vioxx, that have been withdrawn from the pharmaceutical market. FTY720, a drug developed by Novartis, has shown considerable t...

Does natural selection drive the evolution of cancer?

...are that cancer cells no longer heed normal growth inhibition signals in their environment, they no longer require an external signal to divide as healthy cells do, and they are able to suppress a vital set of internal instructions that require cells to self-destruct when their genes are mutated beyond repair. ...

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