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Tag: "inhibiting" at biology news

Researchers shed light on mechanism of action used by anti-cancer drug

...cell death. “The notion that sorafenib acts by inhibiting protein synthesis and reducing expression of Mcl-1 suggests that this agent might be logically combined with other targeted agents whose antitumor activity is limited by Mcl-1 expression,” Grant said. Several such targeted agents are currently underg...

Researchers develop buckyballs to fight allergy

...able to ‘interrupt’ the allergy/immune response by inhibiting a basic process in the cell that leads to the release of an allergic mediator. Essentially, the buckyballs are able to prevent mast cells from releasing histamine. Mast cells are responsible for causing allergic response and are packed with granu...

Putting feelings into words produces therapeutic effects in the brain

...tional experiences. It has also been implicated in inhibiting behavior and processing emotions, but exactly what it contributes has not been known. “What we’re suggesting is when you start thinking in words about your emotions —labeling emotions — that might be part of what the right ventrolateral region is ...

Targeting sugar on blood vessels may inhibit cancer growth

...ed vascular endothelial growth factor (VEGF), thus inhibiting the growth of vasculature. The drug has been used...The researchers hope to develop novel therapies by inhibiting endothelial heparan sulfate in the tumor environment. An example would be developing small-molecule...

Molecule that destroys bone also protects it, new research shows

...own side, however, this new finding indicates that inhibiting IL-17 too much could put people taking such a drug at risk for opportunistic infections such as periodontal disease and tuberculosis, she noted. "Developing knowledge about the molecules that contribute to host defense versus pathology is very im...

LIAI scientists make important finding on cytomegalovirus transmission

...he IL-10 protein in the salivary glands of mice by inhibiting binding of IL-10 to its receptor. "IL-10 is a messenger molecule which suppresses the protective T cell response that would normally attack the cytomegalovirus," he said. "By blocking the ability of the IL-10 molecule to bind to its receptor, then ...

Cow protein aids in treatment of gastrointestinal disorder

...errin has previously been found to be effective at inhibiting the growth of microorganisms and reducing the side effects of antibiotics, respectively, but the new study marks the first time that they have been used together to treat H. pylori. The study found that the infection-causing bacterium was eliminated ...

Gene thought to assist chemo may help cancer thrive

...e tumors had a functioning p53. If we are correct, inhibiting p53 in tumors being treated with chemotherapy may substantially improve patients' long-term survival." McDonald and colleagues are continuing to test their theory by conducting studies in cell cultures and mice. If it bears out, then disabling the...

2 brains -- 1 thought

...ible networks. Each combination can have either an inhibiting or an activating effect on the downstream neuron and, in addition to this, can differ in its intensity and reaction time. The entirety of all possible networks of a defined dynamics resembles a complex figure in a multidimensional space. Here, every ...

Aspirin discovery may improve cancer treatments

... of the translation initiation factor eIF2Ą, thus inhibiting protein synthesis," Professor Williams said. "Inhibiting or slowing down protein synthesis reduces the accumulation of incorrectly folded proteins in cells, which reduces cellular stress and allows protein synthesis to return to normal." Under...

UCSD researchers discover variants of natural tumor suppressor

...family member, PHLPP2, which also inactivates Akt, inhibiting the cell cycle progression and promoting cell deat...glucose in the bloodstream. Therapies directed at inhibiting PHLPP1 could be used to treat diabetes; in essence, removing the 'brake' and allowing Akt2 to be mor...

Enhancing activity of marijuana-like chemicals in brain helps treat

...d, it is thought that the pathway responsible for inhibiting movement becomes overly activated - leading to the...turns out that the neurons Kreitzer identified as inhibiting motion had a type of dopamine receptor on them that the other cells didn't. The researchers tested ...

Anthrax attack posed greater potential threat than thought

...x vaccines investigate cellular immunity's role in inhibiting the pathogen. ...

New antibacterials being developed to tackle MRSA superbug

...A bacteria to divide and multiply. They do this by inhibiting the function of the bacterium's FtsZ protein, which is essential for cell division. FtsZ is not found in humans so targeting a unique protein like this should reduce the likelihood of side-effects in patients. Because of the novel mode of action of t...

How genetic malfunction causes a form of retardation

... by further promoting the formation of neurons and inhibiting glial cell formation. The researchers also studied the effects of the mutation in mice engineered to mimic the human disorder. Like humans with NS, the mice had only one mutant copy of the SHP-2 gene, while the other was normal. The researchers ob...

Discovery of an HIV inhibitor in human blood points to new drug class

...earchers. "The findings reveal a new target for inhibiting HIV that remains fully active against viral strains that are resistant to other drugs," said study author Frank Kirchhoff of the University of Ulm in Germany. "That's a big advantage." Kirchhoff's group also provided evidence that HIV-1 does not e...

Protein found to shield pancreatic cancer cells from self-destruction

... M. D. Anderson team shows in lab experiments that inhibiting the protein in pancreatic cancer cells leads to a form of programmed cell suicide called autophagy, or self-digestion. TG2 was inhibited in two separate ways. First, the researchers blocked another protein known to activate TG2. Secondly, they als...

Brain networks strengthened by closing ion channels

... network is effectively disconnected. Arnsten said inhibiting cAMP closes the channels and allows the network to reconnect. The study also found alpha-2A adrenergic receptors near the channels that inhibit the production of cAMP and allow the information to pass through into the cell, connecting the network....

Scientists identify a candidate gene for osteoporosis

...may be able to develop therapies that are based on inhibiting the function of the DARC gene," explains Dr. Subburaman Mohan, Ph.D., a Senior Scientist at the Loma Linda VA Medical Center and a Professor of Medicine and Biochemistry at Loma Linda University. "We will also be able to develop genetic screens to ...

Reversing cancer cells to normal cells

...stem cell model and the chick embryo model - where inhibiting Nodal signaling led to the reversal of the melanoma cells to a more normal cell type. This is a promising area of research, says Dr. Hendrix. The discovery of a new signalizing pathway in melanoma and other tumor cell types and the ability to inh...

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