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Tag: "inhibit" at biology news

Activation of microRNA inhibits cancer gene in human cancer cells

...rotect cells from abnormal cell growth. Drugs that inhibit DNA methylation and histone deacetylation, known a... with chromatin-remodeling drugs to simultaneously inhibit DNA methylation and histone deacetylation. A subset of miRNAs was upregulated in the cancer cells bu...

Statins stop hepatitis C virus from replicating

...ypically used as anti-cholesterol medications, can inhibit the replication of the hepatitis C virus (HCV). Th...uggested that, "the statins possess the ability to inhibit the replication of HCV RNA via a specific antiviral mechanism," the authors report. The researchers...

Triple threat polymer captures and releases

...ur years ago as marine "antifouling" coatings that inhibit marine organisms such as barnacles from attaching to the hull of ships to now capture fragrance molecules and release them at room temperature. Wooley mixes two normally incompatible polymers -- a hyperbranched fluoropolymer and a linear polyethyle...

Drug dials down the energy within cells, UM researchers find

..."People had proposed in the past that if you could inhibit this enzyme, there might be therapeutic potential. But the problem is, if you inhibit the enzyme in the way most powerful drugs do, turning it off, you deplete the cell of ATP, and that'...

Mechanism for neurodenegerative diseases linked to transport proteins

...searchers to wonder if the deranged polyQ proteins inhibit fast axonal transport in several diseases, includi...nsport by activating an enzyme called JNK that can inhibit these transport proteins. Brady said this is the first proposed mechanism for polyQ diseases that e...

Gene linked to rare disease activates fat breakdown

...s, while treatments that block CGI-58 in fat cells inhibit the removal of stored triglycerides. Finally, the addition of normal CGI-58 in cells having the CDS mutation restores lipid breakdown and reverses the abnormal triglyceride accumulation typical of patients with the lipid storage disease. "These data...

Gardenia fruit compound starting point for diabetes therapy

... and humans, high concentrations of UCP2 appear to inhibit insulin secretion from the pancreas and increase t...the chemical's cross-linking activity continued to inhibit UCP2, they reported. That's a good sign for the therapeutic potential of genipin-related compounds,...

Interfering RNA silences genes in 'slippery' immune cells

...ent protein into human T cells, and using siRNA to inhibit that gene's expression, and dim its fluorescent glow. They then applied their approach to HALP, a gene naturally active in T cells. Dr. Finkel previously discovered and named HALP, an acronym for "HIV-associated life preserver," showing that it had...

Researchers find protein that silences genes

...ld switch on the silent genes using chemicals that inhibit either DNA methylation or histone deacetylation, indicating that turning off one parental set of ribosomal genes was really the secret to nucleolar dominance. In other words, all the factors needed for expression of the genes were in place but some...

A new kind of mutation could explain numerous phenotypic variations in various species

...scle and the function of the derived protein is to inhibit muscular growth. The mutation discovered among sheep exposed a recognition site for two miRNAs that are highly expressed in the muscle. In "mutant" animals, these miRNAs will consequently target the myostatin gene and block its translation. The resul...

New angiogenesis finding may help fight cancer growth

... excited." Further tests showed that NK-B could inhibit angiogenesis in four ways. It prevents the production of vascular endothelial growth factor (VEGF), a key stimulator of blood-vessel formation, and also reduces the number of receptor molecules that respond to VEGF. NK-B also slows the movement of en...

Scientists use gene signatures to match cancer and other diseases with potentially effective drugs

...er drugs. It turned out that celastrol and gedunin inhibit a molecule called HSPH90, which in turn blocks the overactive cell signaling of the androgen receptor in prostate cancer cells that drives their aggressive growth. Dana-Farber researcher Haley Hieronymus, PhD, who used the Connectivity Map to sift th...

Key molecular signaling switch involved in allergic disease identified

...llergic response. The identification of drugs that inhibit ADAM10's ability to release this molecule could revolutionize treatment of asthma and allergic disease. "Our research, for the first time, may represent a treatment strategy to prevent, rather than simply control IgE-mediated allergy," said Daniel...

Targeted virus compels cancer cells to eat themselves

...ues reviewed therapies and molecules that cause or inhibit the self-cannibalization process and compared autophagy and apoptosis, which has been more heavily studied. To improve cancer therapeutics, Kondo and colleagues concluded that it is vital to identify molecules that regulate autophagy in cancer cells...

Striking the right balance between excitation and inhibition

...t and amplify signals, and inhibitory neurons that inhibit and refine those signals. Although investigators have long appreciated that these two classes of neurons exist in the central nervous system, little is known about how cells decide to become inhibitory or excitatory during embryonic development. Res...

How does a zebrafish grow a new tail?

...his is very exciting, because this gene might also inhibit regeneration in mammals and man. So, if we find ways of interfering with the function of Wnt5b, we might be able to promote regeneration." Moon added that, because the same genes for turning on and turning off growth and development are found in hu...

New path from estrogen to survival in breast cancer cells described

...sible to interfere with a number of the players to inhibit cancer growth. "NEDD8 is key," he said. "It may be possible to design drugs that block the removal of NEDD8 from BCA3." By increasing the amount of NEDD8-modified BCA3, there will be a corresponding decrease in the level of NFkB and the cancer cells...

Cancer stem cells linked to radiation resistance

...g, called debromohymenialdisine, which is known to inhibit the proteins involved in the activation process. They added the drug before and after radiation treatment and measured the number of surviving cancer stem cells. They found that administering the drug before radiation did little to change the numb...

New target for cancer therapy identified

...ancer agents that mimic these proteins and thereby inhibit the production of telomerase. " ...

Novel EGFR ectodomain mutations in glioblastoma

... this protein. Fortunately, the drugs developed to inhibit EGFR have broad activity, which bodes well for the use of these drugs in patients with glioblastoma. ...

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