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Tag: "inhibit" at biology news

Montreal researchers probe the genetic basis of memory

...e, and the silencing of proteins such as GCN2 that inhibit memory storage." Although research on humans is still a distant possibility, the scientists believe their discovery may hold promise in the treatment of a variety of illnesses linked to memory. "The discovery of the role of GCN2 in long-term memory ...

Scientists discover that three molecules may be developed into new Alzheimer's drugs

...from a search of 58,000 compounds –?that appear to inhibit a key perpetrator of Alzheimer's disease. Each of... process. The researchers set out to find a way to inhibit this enzyme, to keep it from putting any phosphate on tau. In the laboratory, they purified the enz...

Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels

...from a search of 58,000 compounds –?that appear to inhibit a key perpetrator of Alzheimer's disease. Each of... process. The researchers set out to find a way to inhibit this enzyme, to keep it from putting any phosphate on tau. In the laboratory, they purified the enz...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

...tegrin as the lock and VCAM as the key. Drugs that inhibit either the integrin or the VCAM molecule prevented intact blood vessels from forming. "When the integrin meets with VCAM, both cell types receive survival signals at this active stage of blood vessel development, which occurs mainly in tumors in adu...

Harmless virus may hold key to more effective HIV drug discovery

...developing resistance to broad-spectrum methods to inhibit its expansion. Because of this, the development of effective HIV drugs has been difficult and expensive. Weiss and Olszewski found that the bacteriophage can model millions of different mutational variants of an HIV protein called Nef. Knowing how t...

Study shows how retinoic acid enters a cell's nucleus

...d switching genes on and off. In this role, RA can inhibit tumor growth. In fact, past clinical trials have shown that RA can help treat leukemia, head, neck and breast cancer. RA and its synthetic derivatives may also be useful in treatment of diabetes, arteriosclerosis and emphysema. Unfortunately, convent...

USC researchers determine mechanism of action of chemotherapy drug

...und-zinc in the cells. The zinc, in turn, acted to inhibit an enzyme-thioredoxin reductase-that is an important component in the cell's antioxidant system, as well as important in DNA synthesis. In other words, thioredoxin reductase is key to the replication and survival of cells, and its inhibition ultimate...

Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress

...ivity of the hypothalamic neurons serve to rapidly inhibit hormone secretion from the pituitary gland, providing a rapid negative feedback mechanism for the regulation of neuroendocrine function during stress." Japanese team finds inhibition of excitatory and inhibitory synaptic transmission In an in vitro...

New lead reported in tumor angiogenesis

...al years, various compounds have been developed to inhibit secreted proteins such as the much-studied vascular endothelial growth factor, or VEGF, which clearly plays a role in tumor angiogenesis," said Wang. "To date, though, none of these compounds have been very effective as cancer therapies, suggesting t...

Bitter or sweet? The same taste bud can tell the difference

...might excite the bitter taste and at the same time inhibit the sweet taste, so the bitter message gets to the brain." Although the researchers did not examine how either taste affected individual cells (they plan to do that next), Herness thinks that CCK may override NPY during a bitter sensation, while NPY...

Structures of marine toxins provide insight into their effectiveness as cancer drugs

... provides an excellent target for drugs that could inhibit such rapid growth." Adds Allingham: "These marine toxins can knock out the lynchpins in these long chains or cap their ends and kill cancer cells. Moreover, initial work shows that even a low dose of these toxins can bring a significant response."...

Researchers create infectious hepatitis C virus in a test tube

...of host cells compete with membrane-bound CD81 and inhibit entry of HCV into the cell. They also showed that HepG2 cells, which do not express CD81 but can support HCV RNA replication, could not be infected by HCVcc unless they express CD81. Liver failure due to hepatitis C is the leading cause of liver tra...

Duke Experiments Boost Radiation's Cancer-Killing Effects

...me of HIF-1's effects promote cancer, while others inhibit cancer, so it is critical to block the protein at ...ng HIF-1 in the right environment can dramatically inhibit the growth of new blood vessels that feed the tumor." A multitude of factors influence how HIF-1 be...

IBM Transforms the Art of Scientific Expeditions

...me of HIF-1's effects promote cancer, while others inhibit cancer, so it is critical to block the protein at ...ng HIF-1 in the right environment can dramatically inhibit the growth of new blood vessels that feed the tumor." A multitude of factors influence how HIF-1 be...

One bacteria stops another on contact

...rrently exploring how contact between bacteria can inhibit cell growth �� and determining what this contact-d...a system by which one cell can contact another and inhibit its growth." ...

Newfound roadblock to interferon effectiveness against malignant melanoma

...that blocks the ability of the drug to effectively inhibit growth. Confirming this initial finding, the researchers found that when they inhibited STAT5 in interferon-resistant melanoma cells, they were able to restore the effectiveness of interferon. This demonstrates the relevance of STAT5 and its contrib...

Aloe vera coating may prolong freshness, safety of fruits and vegetables

...antifungal compounds that can potentially delay or inhibit microorganisms that are responsible for foodborne illness in humans as well as food spoilage. Although the health effects of Aloe gel on human consumption were not directly measured in this study, the coating is believed to be safe, the researcher...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

...ive. Instead of looking for chemical compounds to inhibit BACE1, Oded Singer, collaborating with the laboratories of Fred H. Gage at the Salk Institute and lead author Eliezer Masliah at UCSD, resorted to small biological molecules, called short interfering RNA, or siRNA, which derail the process of transla...

Colorful bacteria more dangerous

...e to immune attack. Nizet suggests that drugs that inhibit carotenoid synthesis might be useful for treating S. aureus infections, which can quickly develop resistance to traditional antibiotics. ...

Researchers find molecule that inhibits regrowth of spinal nerve cells

...ars to identify elements in myelin that chemically inhibit the regeneration of nerve cells, Dr. Parada said. Three individual components ?the molecules Nogo, MAG and OMgp ?have been shown to do so in isolation. Developmental biologists at UT Southwestern have been studying how ephrin-B3 helps control how and...

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