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Tag: "inhibit" at biology news

New push for public health, AIDS spending at African Union summit

...with a cocktail of antiretroviral (ARV) drugs that inhibit the progression of their disease, which has no known cure. But demand for free drugs vastly outstrips their supply, the cost of the drugs - at some $US600 annually for the rest of a patient's life, an impossible dream on the continent. Generic vers...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...w route to inhibiting HIV ?by using compounds that inhibit the shape change," says Harrison. He notes that some HIV inhibitors already in development seem to inhibit the shape change; the new findings may help pin down how these compounds work and hasten their devel...

Computers to be used to find blueprint for new influenza drug

...cally similar to the sialic acid, but would act to inhibit the sialidase. This would hinder the virus from entering the cells, and from leaving them should they gain entry, thereby controlling the spread of the infection. Because of similarities between the enzymes used by different viruses and bacteria, a ...

Combination therapy boosts effectiveness of telomere-directed cancer cell death

...lseems to block their function, preventing them to inhibit completelythe telomerase. What to do then? Scrap the project? Look for somethingelse? Hell no! Look out for whats stopping the drug! Perseverance issometimes worth it, as we can see .A new research study published in the January issue of Cancer Cellp...

GATA: a graphic alignment tool for comparative sequence analysis

...lseems to block their function, preventing them to inhibit completelythe telomerase. What to do then? Scrap the project? Look for somethingelse? Hell no! Look out for whats stopping the drug! Perseverance issometimes worth it, as we can see .A new research study published in the January issue of Cancer Cellp...

Research on Worms Yields Clues on Aging

...rms as modelorganisms to investigate how the drugs inhibit seizures in epilepticpatients, a mechanism that currently is not well understood. Suchresearch could lead to more effective treatments for epilepsy....

NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

...erent stages of the virus' life cycle. First, they inhibit viral RNA and protein synthesis. If this fails, interferons block the virus from forming particles which can be released and infect other neurons. This is critical, since the immune system does not kill infected precious neurons the way it does other...

Scientists rid stem cell culture of key animal cells

...an embryonic stem cells to differentiate appear to inhibit differentiation in mouse embryonic stem cells. Aside from feeder cells, two other sources of animal material remain in stem cell culture materials. One, Matrigel, is a product that is essentially a plate-coating matrix of cells extracted from mouse ...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...ural compound called migrastatin, which appears to inhibit cell migration. Natural migrastatin's effect is relatively weak, but Dr. Huang suspected the molecule might be manipulated into something more potent. In collaboration with the laboratory of Dr. Samuel Danishefsky at the Memorial Sloan-Kettering Can...

Beyond lithium for bipolar disorder

... drugs to treat the disorder. Lithium is known to inhibit the production of an important cellular switch, called inositol monophosphate, so the researchers set out to find genes that were activated by this inhibition. They treated slices of rat brain with lithium chloride as well as a chemical that depletes...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

... for an effective and specific molecule that could inhibit Icmt function. "We were looking for a small molec...en the scientists tested the compound's ability to inhibit Ras function in living cells, they found it blocked the ability of colon cancer cells to grow indepe...

Key Trigger Of Opioid Withdrawal Symptoms Found

...e morphine and heroin. They believe that drugs to inhibit the chemical--called a transporter--could relieve ...Importantly, the researchers found that drugs that inhibit either the GABA transporter activity or protein kinase A eliminate the hyperexcitability of the PAG ...

VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain

...ption. If researchers can identify drugs that may inhibit or activate the function of one of the genes identified in these studies, they may be able to generate new treatments for alcoholism or addiction, Miles said. "The genes identified in our studies may eventually lead to other studies that can evaluat...

NYU study reveals how brain's immune system fights viral encephalitis

...erent stages of the virus' life cycle. First, they inhibit viral RNA and protein synthesis. If this fails, interferons block the virus from forming particles which can be released and infect other neurons. This is critical, since the immune system does not kill infected precious neurons the way it does other...

Norovirus, AIDS vaccine and Hepatitis Virus

...s Virus A newly identified family of proteins may inhibit replication of the Hepatitis B (HBV) and C (HCV) v..., interferon lambda, was tested for its ability to inhibit HBV and HCV replication. Results showed 90% inhibition of HBV after twenty-four hours and 90-99% inh...

Iron exporter revealed that may explain common human disorder

...portin and targets it for destruction. Drugs that inhibit or degrade ferroportin might therefore curb the iron overload suffered by those with hemochromatosis, Andrews said. Those with excess iron for other reasons, such as repeated blood transfusions, might also benefit from such a drug, she added. The ot...

Stopping smallpox in its tracks: A new anti-viral approach

...ws that drugs that interfere with erbB-1 signaling inhibit SPGF-induced viral replication and spread. The authors show that treatment with these erbB-1 inhibitors are effective in lowering morbidity and mortality, and boosting T cell immunity, in infected mice. In an accompanying commentary, Anthony Fauci a...

Scientists discover how plants disarm the toxic effects of excessive sunlight

...lth, because it is often used as a host defense to inhibit the growth of unwanted microbial pathogens. In fact, it appears that even non-photosynthetic bacteria, including human and animal pathogens like Vibrio and Pseudomonads have systems to sense and protect themselves from singlet oxygen, says Donohue. O...

Brain-mapping technique aids understanding of sleep, wakefulness

...wa said. "In order to fall sleep, you somehow must inhibit these orexin neurons. It appears that sleep-active neurons in a specific region of the brain are doing just that, keeping the animals asleep." The researchers also found that during wakefulness, orexin neurons activate cells in other parts of the br...

Brain-injury rehabilitation depends on acetylcholine circuitry

...ical injury." They also concluded that drugs that inhibit breakdown of acetylcholine or those that encourage brain wiring growth "may enhance cortical plasticity and improve functional recovery following nervous system injury." The researchers also noted that brain circuitry that depends on other types of ...

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