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Tag: "infused" at biology news

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

... of the faulty enzyme in those with the disease is infused weekly. In clinical trials of the replacement therapy, the infusions have already prolonged the lives of many babies with Pompe disease, Koeberl said. "A number of babies have been receiving enzyme replacement therapy for several years," said Koeber...

Genetically modified natural killer immune cells attack, kill leukemia cells

...lly modified. These modified NK cells will then be infused into the patient after the transplant in order to eliminate residual leukemic cells. In another application, NK cells could be obtained from a patient while in remission and then reinfused after genetic modification if the patient suffers a resurgenc...

Rare surgery performed to remove pancreas, prevent diabetes

...cells were then returned to the operating room and infused into the patient's liver, where they have begun to produce insulin. Few hospitals have the technologically sophisticated facilities necessary to isolate and purify the pancreatic islet cells either from a cadaver donor for transplantation or, as in ...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

...lly modified. These modified NK cells will then be infused into the patient after the transplant in order to eliminate residual leukemic cells. In another application, NK cells could be obtained from a patient while in remission and then reinfused after genetic modification if the patient suffers a resurgenc...

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

...m cultures of erythromycin-producing bacteria were infused with fluorescent dye and applied to the microarray. "This experiment revealed that the RNA transcript abundance of the erythromycin-producing genes remained higher for longer times in the Saccharopolyspora erythraea mutant strain," Kao said. Search...

Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect'

...heir average pain ratings per volume of salt water infused -- in other words, the placebo effect was strong. The other five were classified as "low placebo responders." These subjective ratings are consistent with previous findings, Zubieta notes. But the simultaneous imaging of the participants' endogenous...

HIV Therapy Greatly Extends Life of Key T Cells, Scientists Find

...r. In the first set of experiments, investigators infused 32 volunteers with a sugar solution containing a harmless chemical label, deuterium (a non-radioactive, stable isotope), for five days. Nine volunteers were HIV-positive but had never received IL-2; 15 volunteers were HIV-positive and had received be...

Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

...iral vector with a human GAD gene (cDNA) were then infused at 0.5 microliters/minute, together with 15 microliters of 25% mannitol. After the 100-minute infusion period, the delivery catheter was withdrawn and the incision closed. No hardware was left behind following this procedure, and all patients were...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

... rats with ischemic/reperfusion (I/R) ARF. Animals infused with MSC either immediately or 24 hours after reperfusion had significantly better renal function, lower renal injury and cell-death scores, and higher cell division indices than vehicle-treated control animals," the paper stated. Indeed, administrat...

Bone marrow stem cells may heal hearts even years after heart attacks

... After processing, stem cells from the marrow were infused through a catheter into the coronary artery where the patient's heart attack occurred. "The main results were at least threefold: an improvement in global left ventricular function by 15 percent, infarction wall movement velocity rose 57 percent, an...

A single sugar found responsible for an antibody's ability to treat inflammation

...lupus, arthritis and asthma. And yet, when IVIG is infused into people with those exact autoimmune conditions, it calms inflammation rather than causes it. Jeffery Ravetch, Theresa and Eugene M. Lang Professor and head of Rockefeller's Laboratory of Molecular Genetics and Immunology, was struck by this in...

Need to pull an all-nighter?

...tive. In contrast, when the basal forebrain was infused with a nitric oxide "donor" ?an agent that boosts nitric oxide levels ?during a normal sleep-wake cycle, adenosine levels increased and the rats fell into a sleep much like the "recovery" sleep that occurs after prolonged wakefulness. Blocking adenos...

Monoclonal antibody reduces exacerbations in asthmatics

...yal Brompton Hospital in London, and 11 associates infused 14 patients with infliximab, a monoclonal antibody that binds and neutralizes tumor necrosis factor alpha (TNFá). Eighteen patients received placebo during the eight-week double-blind study. According to the investigators, both structured and inflam...

St. Jude announces breakthrough in eye cancer treatment

...ystemic treatment, such as chemotherapy, a drug is infused into the body through a vein and then circulates, often causing toxic side effects that are especially challenging in children. After demonstrating that nutlin-3 is effective when applied directly to the eye, the St. Jude team modified the treatmen...

Power-boosting signal in muscle declines with age

...K activity compared to younger animals. Young rats infused with a stimulatory chemical showed an increase in muscular AMPK activity not seen in old rats, they found. Similarly, the muscle of exercise-trained young rats showed more than a doubling in AMPK activity. In older rats, that AMPK hike with exercise ...

UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

...ody's immune system. DeNardo and her colleagues infused trillions of the probes -- more than 10,000 can fit on the end of a straight pin -- into the bloodstreams of laboratory mice bearing human breast tumors. Once in the bloodstream, the probes began to seek out and latch onto receptors on the surface of...

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