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Tag: "influence" at biology news

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...rs, including me, expect epigenetic differences to influence progression -- whether a tumor would grow slowly or quickly, or whether it would spread," says Feinberg. "But, in this case, our results show that loss of imprinting of IGF2 contributes to colon cancer's development in the mice. It doesn't cause tumo...

Research on Worms Yields Clues on Aging

...ticonvulsants may affect aging partly throughtheir influence on the neural system involved in the insulin signalingpathway and partly through an independent mechanism, according toKornfeld."Our experiments show there is an important connection between neuralfunction and longevity," Kornfeld says. "We're contin...

Novel Enzyme Shows Potential As An Anti-HIV Target

...r protein. Histone acetylation was long thought to influence transcription by regulating the structure and function of chromatin, which is an assembly of proteins (mostly histones) and DNA. Another, more widely accepted model proposes that histone acetylation controls transcription by recruiting cofactors requ...

Study finds more than one-third of human genome regulated by RNA

...r Burge, provides thefirst evidence that microRNAs influence a large percentage of life'sfunctions.The team developed a computational method to define the relationshipbetween microRNAs and their target genes. In December 2003, the samegroup identified 400 genes in the human genome targeted by microRNAs.(Prior ...

NYU researchers simulate molecular biological clock

...r Burge, provides thefirst evidence that microRNAs influence a large percentage of life'sfunctions.The team developed a computational method to define the relationshipbetween microRNAs and their target genes. In December 2003, the samegroup identified 400 genes in the human genome targeted by microRNAs.(Prior ...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...velopment,"says Reinisch. "Fluctuations in PKA may influence not only neuronalmaturation but also how neuronal networks are constructed duringdevelopment," she says. Alterations of this enzyme may affect neuraldevelopment and neural connections by activating or inactivating otherproteins.Demonstrating that cla...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...velopment,"says Reinisch. "Fluctuations in PKA may influence not only neuronalmaturation but also how neuronal networks are constructed duringdevelopment," she says. Alterations of this enzyme may affect neuraldevelopment and neural connections by activating or inactivating otherproteins.Demonstrating that cla...

An HIV Protein Plays a Surprising Role in Gene Activation

...he next round of experiments, which explored Tat's influence on transcription and PIC assembly on the HIV promoter. As expected, transcription factors were “virtually undetectable?at the core promoter in the absence of Tat. Adding Tat recruited all the usual transcription factors to the promoter and increased ...

Gene variations explain drug dose required to control seizures

...ciple that genetic differences between patients do influence variation in response to anti-epileptic drugs for ...able, he said. Patients' genetic makeup might also influence the dose of chemotherapy needed to successfully fight a tumor, while minimizing often intolerable si...

BRCA1 causes ovarian cancer through indirect, biochemical route

...enstrual cycle-the ovarian granulosa cells-have an influence on ovarian cancer." But how? Was that influence direct, or indirect? Dubeau eventually got a handle on the problem by looking at ovarian cancer rate...

Highly adaptable genome in gut bacterium key to intestinal health

...ry carbohydrates varies among individuals and what influence that may have on weight. ...

Alcohol's effects on gene expression in the central nervous system

... identify chromosomes and chromosomal regions that influence alcohol drinking and response to alcohol." # Intracranial self-administration of ethanol into the posterior ventral tegmental area (VTA) of alcohol-preferring rats produced results suggesting that the reinforcing effects of alcohol are activating VT...

Zebrafish may hold key to understanding human nerve cell development

...together. Gliacommunicate with each other and even influence synapse formationbetween neurons.Piotrowski's research in zebrafish focuses on the development ofsensory neurons known as hair cells. Like humans, zebrafish use haircells to detect sound and motion. However, in humans hair cells areburied deep inside...

Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined

...together. Gliacommunicate with each other and even influence synapse formationbetween neurons.Piotrowski's research in zebrafish focuses on the development ofsensory neurons known as hair cells. Like humans, zebrafish use haircells to detect sound and motion. However, in humans hair cells areburied deep inside...

GenMAPP 2.0 released

...together. Gliacommunicate with each other and even influence synapse formationbetween neurons.Piotrowski's research in zebrafish focuses on the development ofsensory neurons known as hair cells. Like humans, zebrafish use haircells to detect sound and motion. However, in humans hair cells areburied deep inside...

Tiny scaffolding allows stem cells to become working fat cells

...ommunity of cells finds itself has a great deal of influence on the biology underway within those cells," Kniss said. "And that biology is always translated into changes in gene expression and assemblies of proteins." That is why the three-dimensional scaffolding for cell growth in the laboratory is so importa...

Bird Brains Show How Trial and Error May Contribute to Learning

... area lowering its frequency. The moment-by-moment influence of this brain region on song is a new observation, Brainard said. Next, the researchers analyzed the relationship between song and the natural neural activity of LMAN during the two types of male finch song, the performance-quality song directed at ...

The Bacteria's guide to survival

...s support previous speculations that some bacteria influence gene expression and the fate of cells in their hosts by tugging on the host cells' membranes with their pili. For bacteria like N. gonorrhoeae that pass directly from host to host, the researchers argue, it would be in a bacterium's interest to help ...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...t only attract transcription factors, but may also influence the local topology of the DNA, thereby controlling access to their associated gene. Several clusters also appear in regions without any known genes—the identification of these clusters might lead to the discovery of new developmentally significant ge...

Children's taste sensitivity and food choices influenced by taste gene

...bute to taste preferences, at times overriding the influence of genetics. The findings may help to explain why... Unlike children, bitter receptor genotype did not influence sweet preference in adults. Instead, effects of race/ethnicity were the strongest determinants. Menn...

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