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Tag: "inflammatory" at biology news

Cycles of cell death, proliferation key to liver cancer

...er cells) prevents liver cancer, its activation in inflammatory cells, such as tissue macrophages, promotes tumor development. In their latest work, the research team studied what precedes inflammation ¡V the injury of hepatocytes caused by toxic chemicals, which sets in motion the inflammation process. Their ...

How can identical twins be genetically different?

...sue of Arthritis and Rheumatism. RA is a chronic inflammatory disease that damages joints. RA causes pain, loss of movement, and bone deformities. It affects 2.1 million Americans. There are many genetic factors that put people at a high-risk for developing RA, yet only 15 percent of identical twins will both d...

First human study confirms that immune cells can be a primary cause of bone loss in gum disease

...steoclastogeneis, and the pivotal role it plays in inflammatory bone resorption. The aim of this study, which will be published in the September issue of the American Journal of Pathology, was to identify the cellular source of RANKL in the bone resorptive lesions of periodontal disease. An active periodontal l...

Pest control research leads to pain control discovery

...o pain relief for sufferers of arthritis and other inflammatory diseases, say researchers at the University of California, Davis. The finding, hailed by a noted inflammatory disease expert "as the most important discovery in inflammation in more than a decade," may also red...

Revolution in the fight against cancer & viruses

...a danger siRNA-based drugs could cause a dangerous inflammatory response. Professor Williams and his team have now discovered the physical structure of siRNA are key to creating effective anti-cancer and anti-viral drugs. This will allow both the development of siRNA-based drugs to react differently for differen...

Parasitic worms used to fight bowel disease

...ating the role that parasites can play in treating inflammatory bowel disease, or IBD, in humans. Her research is...oughout the developed world may be responsible for inflammatory bowel disease, as well as a whole range of autoimmune disorders. According to this "hygiene hypothes...

New genes implicated in rheumatoid arthritis

...ic clues into rheumatoid arthritis (RA), a chronic inflammatory joint disease. While its specific cause is not ye...rther insights into the genetic components of this inflammatory disease, but also to help identify candidates for therapeutic intervention. ...

Mice lacking key immune component still control chronic viral infections

...ither destroy the cell displaying the part or emit inflammatory hormones known as cytokines that trigger other immune defense measures. Because the genetically modified mice used in their experiment lacked the genes that contain instructions for making MHC Class I molecules, Virgin and his colleagues expected t...

UC Davis study finds HIV hiding from drugs in gut, preventing immune recovery

...re suppressed, while the genes responsible for the inflammatory response were more active than in normal tissue. Dandekar said these results suggest anti-inflammatory drugs may improve antiretroviral treatment outcomes. She also pointed out that genes involved with the repair and regeneration of gut-associated ...

Johns Hopkins lab scientists tame overactive CF protein

...ammation caused by cytokine IL8, which is the main inflammatory chemical produced by CF damaged cells. "Targeting VCP, we were able to achieve two things at once -- restoring chloride channel function and curbing inflammation" says co-author Neeraj Vij, Ph.D., a postdoctoral fellow at the Children's Center. "Inh...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

... eliminate pathogens or tumors, but also may cause inflammatory diseases, von Andrian said. Dendritic cells teach, T cells learn "We specialize in various types of intravital microscopy to find out how leukocytes -- the white blood cells of the immune system that fight infection -- find their way around the b...

Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent

... modulation and change in Th1 and Th2 cytokine and inflammatory immune responses to the anticipation and experience of the positive mood state changes associated with mirthful laughter." Future research in this area with more subjects "needs to elaborate these findings in psychoneuroimmunology understanding and ...

Researches discover gene critical for protection against septic-shock-induced death

...is a complex disease characterized by an increased inflammatory response in the body's attempt to combat an infect...ms such as bacteria, fungi or viruses. A weak host inflammatory response can lead to greater infection, whereas an excessive inflammatory response may lead to tissu...

Anti-inflammatory drug's potentially deadly side effect found to be rare

...he drug to treat patients with Crohn's disease, an inflammatory bowel disorder. "Our analysis suggests about one ...i. The drug is a monoclonal antibody that binds to inflammatory immune T cells and prevents them from crossing membranes that protect the brain and the central nerv...

Inflammation and drugs to control this activity studied in a variety of tumors sites

..., scientists are closely studying the link between inflammatory processes and tumor formation, while others are in...," said Scheurer. "It's apparent that some type of inflammatory response is playing some role in the development of brain tumors. We don't know exactly what that ro...

New method enables gene disruption in destructive fungal pathogen

...identifying molecules from the fungus that trigger inflammatory and other types of immune responses in humans. By understanding how fungi modulate immune responses in humans, new ways of developing therapeutics for these conditions could be identified. ...

Brain's own cannabis compound protects against inflammation

... cannabinoid ingredient alleviates symptoms of the inflammatory disease multiple sclerosis (MS). Also, researchers... adding AEA to such damaged brain tissue abolished inflammatory damage to the brain cells, but did not reduce the primary "excitotoxic" damage from the chemical. Th...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

...mmation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, a...rovide a method to treat a wide variety of chronic inflammatory diseases. "It appears that IL-25 has a Jekyll and Hyde personality: it can be helpful or hurtful d...

UCLA paper examines how one disease may prevent another

...triction include kidney failure, type-II diabetes, inflammatory bowel disease and morbid obesity. Overall, Stiehm proposed that new evidence can be found for using certain viruses to treat diseases such as HIV, which do not respond to other medications. "There have been several studies indicating that HIV pati...

Bone and cartilage growth to blame for heart valve disease

...sed not by a 'wear and tear' phenomenon, but by an inflammatory process likely triggered by high cholesterol that stimulates certain cells to reprogram into bone cells in the aortic valve and cartilage cells in the mitral valve, says principal investigator Nalini Rajamannan, MD, newly appointed director of the Ce...

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