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Tag: "inflammatory" at biology news

Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight

...rs for prostaglandin E2 (PGE2), the most important inflammatory mediator that controls a variety of physiological ...a directly couple the lack of a particular type of inflammatory signaling via EP3R with leptin and insulin increase, glucose tolerance, and white fat accumulation, ...

White blood cells in lung produce histamine seen in allergies

...ng, scientists have discovered that histamine, the inflammatory compound released during allergic reactions that causes runny nose, watery eyes, and wheezing, can be produced in large amounts in the lung by neutrophils, the white blood cells that are the major component of pus. Pus, a fluid found in infected ti...

Inflammation may play role in metastasis of prostate cancer

...d Karin. "We have shown that proteins produced by inflammatory cells are the 'smoking gun' behind prostate cancer...repressed by a series of events triggered by tumor inflammatory cells, with the result that prostate cancer cells spread. "An excellent inverse correlation betwee...

Stem cells decrease ischemic injury and restore brain function

... which has always been thought to have a toxic and inflammatory role. "Instead, we suggest that the microglia also has a protective function,?says De Simoni. “Moreover our research shows that these cells survive in brain tissue only for a few days and then they are eliminated. This is very important given the pos...

Parasite infection may benefit MS patients

... an overall increase in EDSS. Since MS involves an inflammatory response associated with the production of certain...e infection can result in a decrease in the normal inflammatory response associated with MS. They note that evidence for production of regulatory T cells (which inh...

Protein found to shield pancreatic cancer cells from self-destruction

...peutics, who began 10 years ago studying TG2 as an inflammatory protein. Mehta and colleagues in the past year have connected TG2 overexpression to drug-resistant and metastatic breast cancer, pancreatic cancer and melanoma. Expression of TG2 is tightly regulated in a healthy cell, Mehta says, and is tempor...

Susceptibility to Crohn's disease -- an important new clue

Crohn’s disease is a chronic relapsing inflammatory disorder of the intestinal tract that affects an estimated 0.15% of people in the developed world. Common symptoms include abdominal pain and diarrhea, but the disorder is often associated with debilitating clinical complications. Researchers from th...

Inhibiting blood to save the brain

...ctor is an important player in MS." MS is an inflammatory disease that affects the central nervous system, c... of fibrinogen that failed to bind Mac-1 had fewer inflammatory lesions and less severe MS symptoms. Blocking the interaction between Mac-1 and fibrinogen after th...

Protein may hold key to decreasing organ dysfunction rates in heart transplants

... potentially responsible for regulating the body's inflammatory response during heart transplants. One of the majo...n as ischemia and reperfusion (IR). In particular, inflammatory cells infiltrate the donated heart, which then releases enzymes and other proteins that attack the t...

Blocking immune cell action increases Alzheimer's-associated protein deposits

... Within the brain and central nervous system, the inflammatory process is controlled by immune cells called micro... block CCR2 are currently being tested for chronic inflammatory diseases, and this study's results suggest that such agents could increase the risk of Alzheimer's i...

'Exercise pill' switches on gene that tells cells to burn fat

...vation of PPAR-d in these mice also suppresses the inflammatory response associated with arthrosclerosis. But the genetic metabolic engineering that created the marathon mouse is permanent, turned on before birth. While a dramatic proof of concept that metabolic engineering is a potentially viable approach, i...

MIT bioengineer advances survival, promise of adult stem cells

...th and her clinical collaborators believe that the inflammatory response following transplant may limit survival o...protected the cells from being killed by pro-death inflammatory signals. The soluble version of the factor did not protect cells." So far all of the experiments ...

New imaging technique tracks traffic patterns of white blood cells

...nteract specifically with neutrophils, a subset of inflammatory white blood cells. "The ease and rapidity of this method, and the abilty to combine it with current genetic labeling techniques will greatly aid investigations to elucidate in vivo imflammatory cell behavior, and provide a powerful tool for the devel...

Monoclonal antibody reduces exacerbations in asthmatics

...ccording to the investigators, both structured and inflammatory cells in asthmatics can release TNFá, which is an intercellular messenger protein, a cytokine, produced by white blood cells. "Anti-TNFá therapy has been shown to be effective in patients with rheumatoid arthritis, ankylosing spondylitis, Crohn's di...

Osteoarthritis may be sign of faster 'biological ageing'

Osteoarthritis, the degenerative inflammatory bone disease, may be a sign of faster "biological ageing," suggests research published ahead of print in the Annals of the Rheumatic Diseases. The authors base their findings on a study of almost 1100 people, aged between 30 and 79. Most of them we...

Backache beaten by good vibrations?

...ysiotherapists to accelerate the resolution of the inflammatory process in a multitude of soft-tissue injuries. The study aims to address the unanswered question of whether TU is effective in reducing pain and disability in patients with lower back pain caused by sciatica. "Obviously this will not only help us...

Scientists show drug can counteract muscular dystrophy in mice

...ice showed much fibrous tissue and infiltration of inflammatory cells. Unlike healthy mice, the mice with MD were unable to either run on a treadmill or swim. MD mice given TSA daily for two to three months, however, were virtually indistinguishable from healthy mice, and biophysical studies showed virtually no ...

Origin of inherited pain disorder pinpointed

...d emphasizes the role of such channel disorders in inflammatory pain. Such findings of abnormal function in diseas...he critical role of [this sodium channel] in human inflammatory pain and explain the differential drug sensitivity of PEPD and PE." ...

Hopkins scientists link immune response to 'ghost' parasites and severely congested sinuses

...tie-ins to asthma, which, like nasal polyps, is an inflammatory response of the body's immune system. The theory,...turned on by so-called ghost parasites, the potent inflammatory response is medically very difficult to control. Researchers say that although chitin, a rigid che...

Researchers create mouse lacking key inflammation gene

...cription factor offers a new approach to treating inflammatory disorders along with other immunological condition...l for sale to spearhead discovery of drugs against inflammatory disorders such as arthritis and Crohn's disease. In the study, Boston University researchers crea...

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