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Tag: "infiltrate" at biology news

Protein may hold key to decreasing organ dysfunction rates in heart transplants

...eperfusion (IR). In particular, inflammatory cells infiltrate the donated heart, which then releases enzymes and other proteins that attack the transplanted tissue, and can seriously impair the viability of replacement organs and jeopardize the health of the patient. The identification of Lcn-2 could be a first...

How T lymphocytes attack

...irst time in vivo and real-time, how T lymphocytes infiltrate a solid tumour in order to fight it. These "defen...h a fatal load of enzymes. When T lymphocytes infiltrate a tumour?/b> Before this work by Alexandre Boissonnas and Luc Fetler, no-one had ever observed...

White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

...rophils, macrophages and natural killer cells ?all infiltrate the tumor site in a multi-pronged killing response. "Each cell type had independent killing activity against the cancer cells," the authors said, using different molecules. Macrophages, for instance, have to be in physical contact with the cancer c...

An artificial cornea is in sight, thanks to biomimetic hydrogels

...cornea the "homes" he built for cells that need to infiltrate the artificial lens and integrate it with surrounding natural tissue. "If you build it, they will come," Myung says. "The cells move in, and they bring furniture too--meaning the collagen they secrete. They even 'remodel.'" Collagen binds to the ed...

World's smallest cancer detection device

... would "read" them on the nature of the cells that infiltrate them--in particular, on whether metastatic cells are present that would call for more aggressive cancer therapy. In 2005, Einstein formed an alliance with UAlbany's CNSE to advance education and research in the rapidly growing fields of nanobiotech...

Beaver dams create healthy downstream ecosystems

...er flow in the valley. The changes caused water to infiltrate the river banks and flow underground toward the sides of the valley, instead of down the center of the valley. The researchers suggest that the elevated moisture levels found in soil surrounding the dams would otherwise require water from a very lar...

Nanotechnology may find disease before it starts

...sels, or capillaries, of tumor tissue and actually infiltrate the tumor. "Until now, nobody knew what these particles would do in the blood," Rosol said. "But they made it into the liver. And despite their miniscule size, nanoparticles are still big enough to carry a payload of medicine, Rosol said. "That th...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

...onance imaging (MRI) to track immune cells as they infiltrate a transplanted heart in the early stages of organ ...the researchers then track tagged macrophages that infiltrate transplanted hearts. The locations of the tagged macrophages are highly defined and appear circular ...

Source of crucial immune cell in the skin discovered

...h this disorder, large numbers of Langerhans cells infiltrate organs and tissues throughout the body. So, targeting the pathway by which these cells are formed could lead to new therapies to help children who now face the possibility of lifelong complications. "It is known that Csf-1 levels are elevated in pa...

New study shows SARS can infect brain tissue

...isease of the respiratory tract. But SARS can also infiltrate brain tissue, causing significant central nervous system problems, according to an article in the Oct. 15 issue of Clinical Infectious Diseases, now available online. SARS, a potentially fatal illness caused by a coronavirus, was first reported in A...

Disappearing arctic lakes linked to climate change

...w produces meltwater, which is typically unable to infiltrate into the ground because of the ice-rich frozen soils found in permafrost. Data gathered from the latest measurements indicate that warming temperatures lead to increased numbers of surface water bodies in the colder permafrost regions. Many lakes de...

New imaging technology shown to detect pancreatic inflammation in type 1 diabetes

...is process, white blood cells called T lymphocytes infiltrate the islets of the pancreas (an inflammatory condition known as insulitis), causing the blood vessels to become leaky. Over time, this infiltration of lymphocytes destroys the beta cells, leading to high blood glucose and full-blown diabetes. Today, t...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

...oducing bone marrow cells are like terrorists that infiltrate the nerve-cell populations," he said. They produce proteins that can kill or subvert the purposes of nerve cells "almost like a suicide bomb," said Chan. Diabetes mellitus, which afflicts roughly 18 million Americans, is a major health problem that ...

Bacteria use host's immune response to their competitive advantage

... upper respiratory tracts, waiting for a chance to infiltrate and infect. But long before these bacteria break through our immune defenses, they must first compete against other bacterial species to colonize the mucus-lined surfaces of our noses. Competition between two common nose bacteria involves some inter...

New complete muscle grown in the lab

...ue into the body and waited for the body itself to infiltrate the tissue with blood vessels. "Although this approach has been useful in many tissues, it has not been as successful in thick, highly vascularized tissues such as the muscle," Levenberg says. To create muscle tissue that would be threaded through ...

Undesirable expatriates: Preventing the spread of invasive animals

...ating invasive animals is ensuring that they don't infiltrate our natural areas in the first place. Defined by the authors as animals that have established and spread outside of their native range, many invasive species become economic and ecological burdens. Successful invaders can displace native animals thr...

Genetic defects give the immune system the green light to attack the pancreas

...n the T-cells don’t learn this tolerance, they can infiltrate the pancreas and attack the insulin-producing beta cells.?This first step in the onset of type 1 diabetes is called insulitis. Later in life, within weeks or even years, full-blown type 1 diabetes emerges. An estimated 1 million people in the United...

To control germs, scientists deploy tiny agents provocateurs

... scientists are creating artificial chemicals that infiltrate and sabotage bacterial "mobs." Reporting the work here today (March 13) at the 229th national meeting of the American Chemical Society, University of Wisconsin-Madison chemistry professor Helen Blackwell described the ongoing construction of a new c...

Novel Enzyme Shows Potential As An Anti-HIV Target

... transcription—to copy its RNA genome into DNA and infiltrate human chromosomal DNA. Once the virus is integrated (now called a provirus), its genes can be transcribed. Adept as HIV is in exploiting its host’s molecular resources, the virus can’t establish a foothold without the services of its skeleton crew. ...

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