Molecular 'on/off switch' controls immune defenses against viruses
...r interest is the hepatitis C virus, a blood-borne infection transmitted by intravenous drug use, blood transfu... 1918 pandemic. "Fine-tuning immune response to infection is where antiviral or immune regulatory drugs are headed," said Dr. Gale....Scientists find a key to immune system's ability to remember
... against an individual infectious agent. Following infection or vaccination, Lck initiates a biochemical chain ...that march off to combat the invader. After the infection subsides, the number of T cells marshaled to fight that agent decreases dramatically. But a smaller ...H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses
...ned to determine whether the vaccine would prevent infection by naturally occurring virus. The researchers vacc..., should stimulate antibodies, which help ward off infection if the vaccinated person later encounters the flu virus. In general, the higher the level of antibo...Gene therapy study takes aim at prostate cancer
...rectly into the prostate. While there is a risk of infection with the injection, he said patients will receive antibiotics. Most patients will have some fever after the injection, but it can probably be handled with Tylenol. Doctors will monitor patients after their surgery to determine the effect of the gen...Resistant bacteria increasing source of muscle infection
...pital had started to see a case of the MRSA muscle infection every month. In the cases she studied, the infection was acquired in the community, she said. "I think it is important for parents to be aware that thi...Cell wall of pneumonia bacteria can cause brain and heart damage
...munology. These findings explain why blood stream infection with S. pneumoniae commonly leads to temporary impairment of heart function, and they suggest a way to prevent that from occurring, according to Elaine Tuomanen, M.D., chair of the St. Jude Department of Infectious Diseases. S. pneumoniae is a leadin...Bacterial protein shows promise in treating intestinal parasites
...as comparable to mebendazole for treating hookworm infection in laboratory animals. Additional studies also determined which life cycle stages of the parasite were most susceptible to Cry5B and at what concentrations. "These experiments confirmed that the mechanism of action of Cry5B in Ancylostoma hookworm...Three-in-one virus killer prevents common, often fatal infections
... novel combination therapy drastically reduces the infection rate of three viruses ?and risk of death ?in trans...novirus infections at the moment, so if you get an infection after a transplant it becomes very problematic," said first author Dr. Ann Leen, BCM instructor of p...Solved: The mystery of flesh-eating bacteria's relentless attack
... fail. Necrotizing fasciitis is a serious but rare infection of the skin and the tissues beneath it. The work...he body, few white blood cells appeared at the M14 infection site. A similar phenomenon had been observed in patients with necrotizing fasciitis but did not rece...Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax
... would otherwise destroy it, thus allowing anthrax infection to progress. The toxins are thought to act mainly ...l exposure. However, some animals developed fatal infection after the antibiotic therapy was discontinued. "In spite of the low compliance rates we saw in 2001...Blood transfusion-transmitted infections: A global perspective
...d from more donors; thereby increasing the risk of infection transmission by transfusion. "The possible additional safety interventions that might further reduce the risk of transfusion-transmitted infections will be debated extensively over the next few years," says Blajchman. "Regardless of the outcome...Targeted virus compels cancer cells to eat themselves
...y studying ways to improve the efficiency of viral infection of cancer cells. ......hat the virus might change and that human-to-human infection could then be possible. Should all this happen, th...nd the fact that some people are more resistant to infection than others. From the use of their mathematical model, the researchers concluded that restriction...New study calculates millions of years saved in lives of AIDS patients
...United States are estimated to be unaware of their infection and little more than half of those who are aware of it are actually in care, Dr. Walensky and coworkers calculated that "…an additional 740,000 years of life might have been saved had all AIDS patients in the U.S. received appropriate treatment upon ...Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer
...ells and fusing them, which augments the effect of infection and increases cancer cell death. Mayo's research team has an ongoing clinical study for ovarian cancer. "We've seen early evidence of biologic activity," says Dr. Galanis. "The ovarian cancer trial, though in its early stages, has demonstrated sa...MRSA vaccine shows promise in mouse study
...lationship between antibodies that fight S. aureus infection and surface proteins of the bacterium that facilitate the spread of the infection. S. aureus, often referred to simply as "Staph," is common, found on the skin and in the noses of an estimated 30 percent of people worldwide. It is a frequent source...Control measures fail to stop spread of new H5N1 virus
...his indicates an increase in the incidence of H5N1 infection in 2005-2006 compared with previous years, which suggests that H5N1 viruses have not been effectively contained. The investigators also conducted genetic studies of 390 H5N1 viruses isolated from poultry in the current study (30 percent of the t...Mouse study reveals new clues about virulence of 1918 influenza virus
...tailed picture of the overzealous host reaction to infection by a fully reconstructed 1918 influenza virus," sa...ave rise to the hypothesis that the 1918 flu virus infection provoked an uncontrolled inflammatory response leading to rapid lung failure and death. To test t...Study defines effective microbicide design for HIV/AIDS prevention
...icides being developed for women to use to prevent infection by the virus that causes AIDS. Providing women w...easures as an estimated 12,000 people contract the infection each day, the researchers said. Increasingly, a disproportionate number of women are becoming infect...... if a vaccine against another sexually transmitted infection found widely in that region of Africa ?chancroid ?was relatively easy to develop and could reduce transmission of HIV as much as 10-fold? That may be the case, according to researchers from the University of North Carolina at Chapel Hill's School of...