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Tag: "ineffective" at biology news

Progress toward an antitumor vaccine

...hat such sugar-containing compounds are completely ineffective at stimulating the immune system to form antibodies. “Immunization is only successful if the vaccine is anchored to an immunizing carrier protein by means of a spacer,” explains Kunz. This would be very easy to accomplish with polysaccharides, but tu...

Manipulating nature: Scientists query wildlife birth-control method

...ee grounds. "Firstly, immuno-contraceptives are ineffective against substantial minorities of animals, probably for genetic reasons," Professor Cooper says. "If so, the genes responsible for this lack of response will be passed on to offspring. Within a few generations most of the population will be unrespons...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...y work in treating a single individual but will be ineffective in treating a large percentage of patients," Herlyn says. Herlyn notes that the new antigen-cloning technique developed for this study is a major advance over the cumbersome method previously required to accomplish the task, and she anticipates th...

Batten down the hatches against HIV

...iny bubbles of fat, are safe but have proven to be ineffective for use in T-cells. Dai and his co-workers have tested a new transport system: carbon nanotubes are known for their abilities to be absorbed by cells and to smuggle other molecules in at the same time. The researchers attached phospholipids—molecules...

Bird sex is something else

...ic sex chromosomes. "Unlike mammals, birds have an ineffective dosage compensation," says Arnold. "The finding is surprising because dosage compensation was previously thought to be critical for survival. Birds, however, seem to be doing just fine without sexual equality of Z gene expression". ...

Monoclonal antibody reduces exacerbations in asthmatics

...ng spondylitis, Crohn's disease and psoriasis, but ineffective in patients with chronic obstructive pulmonary disease (COPD)," said Dr. Hansel. "Preliminary reports of efficacy in asthma patients with concomitant rheumatoid arthritis have been encouraging. Small prospective studies of a soluble receptor directed...

Early-stage immune system control of HIV may depend on inherited factors

...lthough the CD8 response against HIV is ultimately ineffective in protecting infection, several studies have suggested that it plays a key role in determining how quickly the disease progresses after initial infection. HLA ?also called major histocompatibility complex (MHC) ?proteins are also the primary mar...

Genome info from 'plant destroyers' could save trees, beans and chocolate

...ophthora are similar to fungi, most fungicides are ineffective at controlling them. The information gained from studying the genomic sequences of P. ramorum and P. sojae will help scientists devise strategies to combat not only these two species, but also other disease-causing Phytophtora. The study appears in ...

'Protecting virus' offers instant flu protection and converts flu infections into their own vaccines

...t one strain of flu, for instance H3N2, is totally ineffective against another, such as H5N1. This is especially problematic when a new pandemic strain emerges, as all existing vaccines are likely to be totally ineffective. Professor Dimmock has spent more than two decades investigating an entirely new method,...

New sunscreen ingredient to heal sunburn and help prevent skin cancer

...rdles in the research were that many chelators are ineffective protectors of cells, and many of them are patented and so cannot be used freely by all researchers. The researchers had to find chelators which were strong enough to export the excess iron out of cells, but that would not have an adverse effect on...

Key to lung cancer chemo resistance revealed

...P1, such as splicing the gene to make a shortened, ineffective protein, he said. The researchers plan to confirm their findings with a larger set of samples and then to screen for appropriate drugs. Funding for the study was provided by the National Cancer Institute Lung SPORE (Specialized Program of Resea...

Report calls for improved monoclonal antibodies against solid tumors

...ill get stuck in the periphery of the tumor and be ineffective except in that location. But if an antibody binds too loosely, it may not stay in the tumor long enough to be effective at all. The authors reviewed the literature to illustrate that the groundwork has been laid to overcome these barriers. Resear...

Research holds promise for herpes vaccine

...use disease. However, subunit vaccines have proven ineffective in protecting people against persistent infections like genital herpes and AIDS, Halford said. "From a theoretical standpoint, subunit vaccines are poor mimics of a natural virus infection," Halford said. "There's not enough there for our immune sy...

Restoring tamoxifen sensitivity in resistant breast cancer cells

...n the cell can become altered, rendering tamoxifen ineffective as an inhibitor. In some cases, tamoxifen begins to act like estrogen and can stimulate tumor growth. DIBA and related compounds are being studied because of their ability to disrupt cellular activity at the genetic level. These so-called electroph...

Blood transfusion-transmitted infections: A global perspective

...teria, viruses and parasites in donated blood, but ineffective against the pathogens that cause neurodegenerative diseases and those viruses that are present in exceedingly high concentrations in blood. Newer technologies can also have a downside, notes Blajchman. They tend to reduce the effectiveness of th...

New strategy developed to combat West Nile Virus

...quitoes, not all birds are good carriers. Some are ineffective hosts, Shaman said, while others ?like crows ?are very susceptible and may die from the virus. Birds that are effective hosts may carry the virus and infect biting mosquitoes for 4-5 days before recovering from the illness. "It is this coming togeth...

New treatment for food poisoning

... ?can treat Listeria in the body, despite it being ineffective in laboratory conditions. Because it was not effective in the laboratory, this drug has never been considered for the treatment of listeriosis, in spite of it reaching the infection sites more effectively than other antibiotics. Professor Vazquez-B...

Researchers appeal for new regulations to save coral reefs from live fish trade

...ts take advantage of porous world trade policy and ineffective fisheries management to sell their plunder," says Dr Helen Scales, from the Department of Zoology, University of Cambridge. By analysing the mass of live fish imported into Hong Kong from various source nations across the Indo-Pacific region, Dr. A...

A sweet solution for Alzheimer's disease?

...ype--myo-inositol--has been shown previously to be ineffective at breaking up amyloid aggregates, he said. In the brain of a person with Alzheimer's disease, small proteins called amyloid â aggregate into plaques, and a protein called tau clumps into neurofibrillary tangles. The brain becomes inflamed and neuro...

Global warming may warrant new approaches to ecosystem restoration

...system conditions as targets and references may be ineffective under new conditions. In addition, there may be less support in the future for longer-term, traditional restoration projects. The authors suggest that, "more consideration and debate needs to be directed at the implications of climate change for r...

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