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Tag: "inducing" at biology news

Resistance and genetic sensitivity to sleeping sickness

...mutations investigated were shown to be capable of inducing in the subject carrying them an increased risk of developing this human trypanosomiasis, or conversely a higher chance of a protector effect (2). The associations brought out between these mutations and the disease necessitate work to confirm this...

A fisheye view of the deadliest breast cancer

... and tapping into the fish’s circulatory system by inducing an angiogenic response. A separate fluorescent labeling allowed the researchers to simultaneously monitor the parental MDA cancer cells and the RhoC-overexpressing tumor cells in the context of the fish vasculature using high-resolution, multico...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...nitric oxide expression, curbing proliferation and inducing apoptosis in human lung cancer cells. They test...n proven effective in inhibiting proliferation and inducing apoptosis (programmed cellular death, a process that's often disrupted in cancer) in breast cancer c...

Distinguishing friend from foe in the battle against cancer

...iggers both inflammatory and survival responses by inducing transcription of specific genes. Not only did this explain why TSC null cells are vulnerable to insult, but it also provided biochemical evidence that there is crosstalk between two survival mechanisms. Explains Tergaonkar, who is now an assistant ...

MIT material stops bleeding in seconds

...ident, however, that the material does not work by inducing blood clotting. Clotting generally takes at least 90 seconds to start, and the researchers found no platelet aggregation, a telltale sign of clotting. Other MIT researchers who are co-authors on the paper are Gerald Schneider, professor of brain a...

Rescuing injured hearts by enhancing regeneration

...iferation of cardiomyocytes also carries a risk of inducing tumor growth, and thus you have to limit the time and location of treatment," Engel adds. One possibility is to inject smaller doses of the agents into the damaged area of the heart in gel form, or instill them through a catheter, so that they wo...

Researchers identify new weapon to fight deadly bacterial sepsis

... molecules called lipopolysaccharides, which go on inducing more inflammatory immune response even though the bacteria themselves are dead." "This inflammatory response causes significant problems with cardiac contractility," Srivastava added, "and so instead of pumping blood properly, the heart just flut...

Tracing the formation of long-term memory

...st and then another trial. The rest is critical in inducing long-term memory that can last days. In this study, the five spaced trials produced a memory that lasted for more than a day. They then used a technique called "functional imaging" to see when the memory formed in the fly’s brain. "Before trainin...

Discovery of the first resistance gene to rice yellow mottle virus

...in other plant/virus interactions, with the aim of inducing resistance to RYMV. The results show that the transgenic plants have only partial resistance, and for only a short time, and can even end up with a heightened susceptibility. In the particular case of the rice/RYMV interaction, the strategy of introd...

An AIDS-related virus tricks cells to become tumors, new Penn study finds

...rt the process of activating genes responsible for inducing growth of more blood vessels to supply the tumor with oxygen. However, in a KSHV-infected cell, p53 and VHL themselves would be targeted for degradation and HIF-1a would then be free to activate genes involved in growth of blood vessels to increase t...

Minuscule molecules pack a powerful punch

... controlling the activity of other genes, often by inducing destruction of protein-coding messenger RNAs or by preventing their activity in the cell. The research team, led by the Wellcome Trust Sanger Institute, targeted a gene called Bic/microRNA-155 (or miR-155) in embryonic stem cells which they used t...

Antibody signal may redirect inflammation to fuel cancer

...ivated to turn on a dangerously different program: inducing leukocytes to boost cell growth, increase the number of blood vessels and "remodel" tissue in the area -- all of which help cancer develop. The finding adds a critical and surprising detail to the emerging view that inflammation, usually a helpful...

Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

...directly or if they are acting on the membrane and inducing a cascade of events resulting in DNA damage," Pacheco said. "Once we understand the mechanisms by which nanoparticles induce their toxicity, we will be better able to prevent or mitigate their harmful effects." In the meantime, the experimental t...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...role in protecting cells from tumor development by inducing cell-cycle arrest or apoptosis via a complex signal transduction network referred to as the p53 pathway. TP53 gene is mutated or deleted in 50% of all malignant tumors. A recently discovered strategy for p53 activation targets the interaction of p53 ...

Mechanisms involved with tumor relapse identified

...types of immune responses in patients, rather than inducing a broad range of immune responses - some of which may be detrimental or may induce tumor relapse," said lead investigator, Masoud H. Manjili, D.V.M., Ph.D., a member scientist with the Massey Cancer Center. "Ultimately, we hope to offer a new poly...

Studies force new view on biology of flavonoids

... of gearing up to get rid of unwanted compounds is inducing so-called Phase II enzymes that also help eliminate mutagens and carcinogens, and therefore may be of value in cancer prevention. "Flavonoids could also induce mechanisms that help kill cancer cells and inhibit tumor invasion," Frei added. It a...

Scientists identify prion's infectious secret

...Also, we’ve seen just one small part of this prion inducing proteins to fold. This is an entirely new concept." Earlier research from the Lindquist lab, published in Nature in 2005, identified the amino acid regions where prions connect with one another to form amyloids. Those interaction regions turn ou...

Penn researchers link cell's protein recycling systems

...roup showed that if the HDAC6 gene is knocked out, inducing autophagy no longer rescues the fly eyes from neurodegeneration. Therefore, autophagy requires HDAC6 to work. They also showed that by simply expressing extra HDAC6, neurodegeneration was prevented in flies with proteasome impairment. Taylor’s group...

Research identifies protein that signals flowering in squash plants

...origen, is produced in the leaves of a plant under inducing conditions, and then is transported through the ph...ll remain in the vegetative state until and unless inducing conditions (such as long nights) occur, and therefore they represent the ideal system for experiment...

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