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Tag: "induce" at biology news

Cocaine high caused by interference in neuronal receiving stations

... protein receptors on the receiving neurons, which induce the nerve impulses in the receiving cell. These receptors also adjust themselves in complex ways to alter the sensitivity of the receiving neuron to stimulation. Researchers had long known that cocaine affects both dopamine and glutamate receptors ...

MIT device draws cells close -- but not too close -- together

...study their interactions. Also, since some signals induce a cell to change its internal programming, it is important for biologists to be able to rearrange cells over time to learn which signals spur change and which don't. In the past, researchers erected chemical "moats" around cells in an attempt to ...

Linking DNA and histone methylation

...ne silencing, how these two processes cooperate to induce silencing has remained unresolved. In their upcoming paper, Dr. Carey and colleagues detail that mammalian HP1 proteins facilitate this cooperation. They found that HP1 proteins, which bind to methylated histones, also interact with the DNA methy...

New insights into autoimmunity and depression

...ain, researchers at Tel Aviv University set out to induce depressive hallmarks in mice. Their findings, presented in the March 2007 issue of Arthritis & Rheumatism ( http://www.interscience.wiley.com/journal/arthritis ), shed light on the brain pathways of depression in general and in central nervous sy...

New science of metagenomics 'will transform modern microbiology'

...thousands of previously unknown microorganisms, or induce the bacteria to express proteins that are screened for capabilities such as vitamin production or antibiotic resistance. The Research Council report was requested by several federal agencies interested in the potential of metagenomics and how best...

Turning a cellular sentinel into a cancer killer

...ues used a genetic technique they had developed to induce an aggressive form of liver cancer in mice. Although they had inactivated p53 in the mice, they genetically engineered the mice so that they could reverse p53 inactivation by giving the animals the antibiotic doxycycline. They suppressed p53 protein ...

New culture method for hepatitis C virus uses primary hepatocytes and patient serum

...000 people worldwide. HCV liver disease, which may induce liver inflammation, cirrhosis, and/or hepatocellular carcinoma, represents the foremost reason for liver transplantation in much of the U.S. Study of HCV replication within liver cells, or hepatocytes, has been hampered by a lack of adequate virus...

Moonlighting enzyme linked to neurodegenerative disease

... by which certain DLD mutations can simultaneously induce the loss of a primary metabolic activity and the gain of a moonlighting proteolytic (breaking down enzymes) activity. The latter could contribute to the metabolic derangement associated with DLD deficiency and represent a target for therapies of this...

Tears reveal some of their deepest secrets to researchers

...a lipid in the brain, where one of its roles is to induce sleep. It also has other key functions throughout the central nervous system. But the current study is the first to find and describe oleamide and related lipids in tear film. "The finding could give us more insight into the role of lipid activity...

RNAi shows promise in gene therapy, Stanford researcher says

...searchers saw some hints that the technique could induce an immune reaction or switch off the wrong gene or genes. In work last year, Kay confirmed those findings but also showed a possible way around those toxic effects by selecting particular RNA sequences. "One benefit of RNAi gene therapy is that...

Active ingredient in common Chinese herb shown to reduce hypertension

...esearchers applied the 2-kidney-1-clip protocol to induce renal hypertension in male golden Syrian hamsters. The animals were anesthetized and a retroperitoneal approach was used to place a silver clip to constrict the right renal artery. Sham-operated hamsters and mice underwent the same procedure, except ...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...was expressed in tumors after treatment. FUS1 can induce apoptosis - programmed cell death - in cancer cel... pioneer in the field of gene therapy. FUS1 can induce apoptosis - programmed cell death - in cancer cells but is absent in those cells. The FUS1 nanopart...

Molecular signature may identify cisplatin-sensitive breast tumors

...growth by interfering with p73’s normal ability to induce cell death. Cisplatin was found to break up the binding of p63 to p73 and reactivate the cell-death process. "The most important finding was that, if the tumor cells did not express both p63 and p73, the cells were not sensitive to cisplatin," say...

Stem cells decrease ischemic injury and restore brain function

... the area of the brain hit by a stroke, stem cells induce the development of a protective effect in this sam...s. Their presence in brain tissue is sufficient to induce a protective reaction." Various cells are involved in this reaction, among which the microglia, w...

Erectile dysfunction in diabetes is due to selective defect in the brain

...e-Dawley rats treated with streptozotocin (STZ) to induce diabetes were used as they exhibit sexual and beha... chemical injection of the streptozotocin (STZ) to induce diabetes. Those rats that did not receive STZ (vehicle injected) served as controls. The experiments...

Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

...e understand the mechanisms by which nanoparticles induce their toxicity, we will be better able to prevent or mitigate their harmful effects." In the meantime, the experimental team suggests that great caution should be taken in handling such nanoparticle suspensions and that any uncontrolled release sh...

White blood cells in lung produce histamine seen in allergies

...ct of the mycoplasma bacteria on neutrophils. They induce neutrophils to produce the enzyme that produces histamine." Individual neutrophils produce much less histamine than individual mast cells, says Caughey, but "because pus contains millions if not billions of neutrophils, the overall amount they make...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...or the KSHV-infected cells since Nutlin-3a did not induce apoptosis in lymphoblastoid cell lines transformed with another human tumor virus, the Epstein-Barr virus, despite of their wt p53 status. Moreover, the researchers show that Nutlin-3a has striking anti-tumor activity in vivo in a mouse xenograft...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

...aper. An effective HIV vaccine likely needs to induce antibodies that can sense and destroy multiple HIV strains. Scientists have sought such broadly neutralizing antibodies by studying the blood of people whose immune systems appear to hold the virus at bay for long periods of time—b12 is one of these ...

Massey researchers induce cell death in leukemia

...omib interacts synergistically with both agents to induce cell death in human CLL cells. Romidepsin and belinostat are histone deacetylase (HDAC) inhibitors. "To the best of our knowledge, this is the first report describing synergistic interactions between HDAC inhibitors and Bortezomib combinations in...

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