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Tag: "induce" at biology news

Turning viruses into allies against cancer

...acrophage colon stimulating factor). Its job is to induce an immune response to any surviving cancer cells released during the initial viral attack, essentially preventing the spread of these cells to other parts of the body. "This aims to treat metastatic disease and reduce tumor recurrence," said Robert ...

Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

...delivery system is a powerful and simple method to induce gene silencing, with the potential to move to clinical trials," said Hu, who presented the results at the 96th Annual Meeting here of the American Association for Cancer Research. In recent years, scientists have been intrigued by the potential of s...

The evolutionary triumph of flower power

...hree studies that tested the ability of flowers to induce positive emotion. The objective was to demonstrate the immediate, long-term and powerful effects of flowers on emotional reactions, mood, social behaviors and even memory in both men and women. The results of these three studies were so positive that...

NYU and MSKCC research provides model for understanding chemically induced cancer initiation

..., it is imperative to understand how chemicals can induce mutations and cancer at the molecular level," added NYU's Broyde. "Such information is needed for devising novel preventive and therapeutic strategies for addressing the problem of cancer induction by environmental chemical carcinogens." The researc...

Scientists discover that three overlapping signals in embryo help get the backbone right

...tructures where the belly would normally form - to induce another head, brain and spinal cord. The tissue they transplanted sent signals to the host to create these new structures." Since then, scientists have searched for the signaling factors secreted by Spemann's organizer. Dubbed bone morphogenetic pro...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

...n agent, the researchers say, because it worked to induce expression of the p21 gene, which they found put a...f the "wild-type" (normal) p27 genes was enough to induce tumor formation in 22 percent of the mice, but that number increased to 72 percent when one allele o...

New polysaccharide may help combat multidrug resistance in cancer

... years, however, hyaluronan has also been shown to induce signaling pathways in inflammatory, embryonic and cancer cells. In their current Journal of Biological Chemistry paper, Dr. Toole and his colleagues report on further studies which indicate that hyaluronan increases the cellular production of a mult...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...accharomyces cerevisiae yeast and human cells that induce mutations that can transform normal cells into cancer cells. The article, "Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance" by Ryan T. Cirz, Jodie K. Chin, David R. Andes, Valöée de Crï'-Lagard, William A. Craig, and Floy...

How A Latent Virus Eludes Immune Defenses

...aposi’s sarcoma–associated herpesvirus (KSHV), can induce uncontrolled lymphocyte (immune cell) proliferation and result in lymphoma, Hodgkin’s disease, and Kaposi’s sarcoma. These diseases arise from the persistent latent infections that take hold after initial infections are controlled by immune defenses....

Touching Molecules With Your Bare Hands

...aposi’s sarcoma–associated herpesvirus (KSHV), can induce uncontrolled lymphocyte (immune cell) proliferation and result in lymphoma, Hodgkin’s disease, and Kaposi’s sarcoma. These diseases arise from the persistent latent infections that take hold after initial infections are controlled by immune defenses....

Chemical Engineer Kao Explores Antibiotic Synthesis With DNA Chips

...nies use chemicals and radiation to damage DNA and induce mutations. But it's not easy to detect these single base-pair mutations in the so-called industrial mutant strains. Kao's group, for example, detected the presence of an unidentified regulator gene altering the timing of erythromycin production, but ...

Disabling gene defuses rheumatoid arthritis in mice

...the new line of mice with antibodies that normally induce a condition like rheumatoid arthritis. But the mice remained healthy even after the injections. "It was a surprise finding," Peng says. "We really didn't expect to see this kind of response." Further study revealed that neutrophils in the mice were...

New understanding of cell movement may yield ways to brake cancer's spread

...a fragment of a protein that senses chemicals that induce a cell to move into the right direction. Guided by this fragment, the molecular machinery needed for cell movement begins accumulating at the leading edge, or front of a cell in response to a variety of chemical messengers, and begins the directed pr...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

... to halt the cycle cell to repair DNA damage or to induce apoptosis. "It came as a complete surprise. We even used a system that would have allowed us to switch on the modified p53 protein at will because we feared that the mice might not be viable and would die during early embryonic development," says Kr...

Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs

...t therapeutics utilize human proteins, they do not induce an unwanted immune response like products created from non-human sources often do." On behalf of Shen and his collaborators, USC holds the patent to the new recombinant fusion protein technology. The research was supported by grants from the Nationa...

Scripps research scientists identify infertility molecule

...in development. Recently, they showed that LPA can induce neurogenesis­the formation of new neurons -- in mice, and can also participate in neuropathic pain models. Wanting to go further, they created what is known as a knock-out mouse model for a specific LPA receptor. These are special mice that lack one...

Scripps research scientists solve structure of a critical innate immune system protein

...ogens by producing large amounts of chemicals that induce inflammation and help the body clear the infection. One of the components of the innate immune system that scientists have been studying for the last several years is a family of receptor proteins called the Toll-like receptors (TLR)--a name that co...

To translate touch, the brain can quickly rearrange its sense of the body

...arch team used a method called tendon vibration to induce a distortion of healthy volunteers' sense of their own bodies. When the biceps tendon of the right arm was vibrated, the subjects in the experiments felt within seconds that their right elbow was rotating away from the body, even though the arm was a...

New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids

...munity provides evidence that bacterial infections induce a kind of self-recognition that may contribute to some autoimmune diseases such as multiple sclerosis (MS) and Guillain-Barre syndrome (GBS). There is evidence that the development of certain autoimmune diseases may be associated with a bacterial or...

How monarch butterflies are wired for navigation

...ole in regulating the insects' hormonal system, to induce the longevity that enables the butterfly to extend its survival in its overwintering grounds in Mexico. The researchers include Ivo Sauman of the Czech Academy of Sciences; Adriana D. Briscoe of the University of California, Irvine; Haisun Zhu, Ding...

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