Signal protein shows promise for blocking tumor promoters in skin cells
...sors of cancer. Breeding experiments with the mice indicated that high Srcasm levels counteracted the effects of Fyn. The findings reveal that levels of Fyn and Srcasm work in a kind of see-saw ?when Srcasm production is low, dangerous amounts of Fyn can build up in cells. But when Srcasm production is inc...OHSU researchers demonstrate how white blood cells cannibalize virus-infected cells
...ers" such as viruses in the body. Previous studies indicated that T-cells may consume parts of cells with which they interact, but this new research shows this can happen in response to a systemic viral infection. "If you use a fluorescent dye to stain infected cells, you can literally watch T-cells consume ...Prion disease treatable if caught early
Studies in mice have indicated that the effects of prion disease could be reversed if caught early enough. The researchers said that their findings support developing early treatments that aim to reduce levels of prion protein in the brains of people with prion disease. Also, they...How does your brain tell time?
... the network could tell time. Their simulations indicated that a specific event is encoded within the context of events that precede it. In other words, if one could measure the response of many neurons in the brain to a tone or a flash of light, the response would not only reveal the nature of the event, ...Major link in brain-obesity puzzle found
... in the journal Cell Metabolism in 2005 that first indicated SH2B1’s key role in obesity. The team and other researchers have found that SH2B1, which was previously called SH2-B, is a kind of jack-of-all-trades in the world of cell signaling. Able to shuttle between the area just beneath the cell membrane a...Scientists reveal structure of gateways to gene control
...e can begin," Pugh said. "Previous research had indicated that DNA sequences located upstream of a gene might be a region that controls whether that gene is read or not, but we did not know the architecture of those sequences -- whether they were exposed and therefore ready for work. Now we know that the g...Coated nanoparticles solve sticky drug-delivery problem
... the size of their nanoparticles. Previous studies indicated that even if nanoparticles did not stick to the mucus, they might have to be smaller than 55 nanometers wide to pass through the tiny openings in the human mucus mesh. (A human hair is roughly 80,000 nanometers wide.) Using high-resolution video micr...Salamanders suffer delayed effects of common herbicide
...sults from the study, which lasted about 500 days, indicated that the two highest concentrations increased salamander mortality during exposure. However, this mortality benefited the survivors who experienced lower competition-related mortality after metamorphosis. Nevertheless, this recovery from atrazin...Anti-herpes treatment reduces HIV levels in women infected with both viruses
...evention. A number of observational studies have indicated that HSV-2 enhances the risk of HIV-1 acquisition by around three-fold2. HSV-2 infection may also increase HIV-1 infectiousness by disrupting the genital mucosa and increasing the levels of HIV in the genital tract3, allowing easier transmissibility ...DNA analysis reveals rapid population shift among Pleistocene cave bears
...ful for tracking population changes). The findings indicated that while four sequence types (known as haplotypes) corresponded to bears 28,000 to 38,000 years old, a fifth DNA haplotype was found only in bears that were 28,000 years old or younger. These data suggested that what had been a stable, long-establi...Triplex assay used to assay duplex genomic DNA
... program, self-cleaning and inexpensive. Daksis indicated that she expected to soon publish data on the use of the Genome Flow® instrument to carry out triplex assaying of genomic samples for pathogens or SNPs. ...Active ingredient in common Chinese herb shown to reduce hypertension
...g/ml caused significant dose-related vasodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25¡À0.08 and 1.57¡À0.11, respectively, in the hamster cheek pouch. The increase in arteriolar diameter ratio was significant relative to the vehicle for each concentration as ...Studies yield insight into the numerical brain
...c numerals) notation as the original. This rebound indicated that the region was processing numerical information. However, to unambiguously establish that the subjects' brains were really reacting to numerical quantity, the researcher occasionally injected a "deviant stimulus" into the second presentation o...Napoleon's mysterious death unmasked, UT Southwestern researcher says
...cancer as the cause of death. A study done in 1938 indicated that Napoleon's father died of stomach cancer. In 1961, an elevated level of arsenic was found in hair taken from Napoleon, inspiring rumors of arsenic poisoning. To find answers, Dr. Genta and the other researchers combined current medical knowle...Common algae helps illustrate mammalian brain electrical circuitry
...t by seeing differences in electrical current that indicated the presence of the algae gene. "This work provides a new method in live animals that will define the experimental approach for studying of mammalian neural circuitry in the coming decade," said Michael Ehlers, M.D., Ph.D., a Duke neurobiologist a...Scientists to track impact of Asian dust and pollution on clouds, weather, climate change
...t by seeing differences in electrical current that indicated the presence of the algae gene. "This work provides a new method in live animals that will define the experimental approach for studying of mammalian neural circuitry in the coming decade," said Michael Ehlers, M.D., Ph.D., a Duke neurobiologist a...Genes and biomarkers that allow doctors to choose the right therapy for the right patient
...indicates a poor response to cetuximab. The study indicated that median survival is 15.6 months for patients with skin toxicity and without a KRAS mutation; whereas the survival is only 5.6 months for patients with the mutation, but no skin toxicity. Dr. Laurent-Puig and colleagues are continuing to invest...Childhood obesity among Quebec Cree raises concerns
...n the International Journal of Circumpolar Health, indicated of the 82 participating children, 33 per cent were overweight and 38 per cent were obese. High waist circumferences were of particular concern, as this measure is often linked to the development of cardiovascular diseases and diabetes. Further st...Shedding new light on proteorhodopsin
... of marine bacteria carrying proteorhodopsin. This indicated that such bacteria can use a form of photosynthesis to supplement respiration as an energy source, but the extent to which light could be used to replace respiration was still unknown. "Our thinking was that if you had a system that could harvest......have been completely degraded, contrary to what is indicated or inferred in the current literature." This underlines the importance of basic scientific research for establishing the priorities for conservation programs and assessments of presumed rare and possibly endangered animals, the study concludes. ...