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Tag: "indicated" at biology news

MUHC researchers make cancer target breakthrough

...Pharma--a McGill University spin-off company--also indicated that the antisense was particularly effective in reducing cancer tumors when administered in low doses and in combination with established cancer drugs. "All drugs and antisense have some level of toxicity," says Dr. Rozen. "An antisense that works i...

Supercomputers to focus brains on AIDS dilemma

...ne site where inhibitors could bind. These studies indicated a single format for small inhibitors of integrase to bind at the catalytic site, typically with a cyclic moiety, or "wing," to the "west" of the active center. Around this same time, the McCammon group began new molecular dynamics studies of HIV-1 i...

Thai spice helps cut blood sugar swings

...Indian folk medicine as a dried powder or tea it's indicated as a laxative and for rheumatism. As Malabar tamarind, it can substitute for lime, and in Ceylon it's used along with salt to cure fish. For HCA, though, the other half of the taste-benefit formula is much less clear. Animal studies suggest HCA may ...

Alcohol consumption disrupts breastfeeding hormones

...g alcohol's effect on breastfeeding. Those studies indicated that infants ingest less milk at the breast in the hours following maternal alcohol consumption, in part due to decreased maternal milk production. Mennella notes, "It's important for women to realize that these data should not frighten them away fr...

Antiretroviral Therapy May Prevent HIV Transmission From Breastfeeding Mothers To Infants

... at the time they were breastfeeding. The results indicated that antiretroviral therapy suppresses HIV RNA in breast milk and may therefore reduce mother-to-child transmission of HIV during breastfeeding. Eighty-eight percent of the women receiving antiretroviral therapy had fewer than 50 copies/ml of HIV-1 R...

Cancer related gene p53 not regulated as indicated by previous tissue culture research

...e culture studies by several labs around the world indicated that tinkering with the tail end prevented the protein from being flagged for degradation or activation. Instead of accumulating in mouse cells and halting cell division in the genetically engineered mice, the altered p53 protein performed flawlessly...

Newly discovered genetic disease sheds light on body's water balance

...eting last September, he said, "Several physicians indicated they were now considering the diagnosis of NSIAD as an explanation for low sodium levels in their pediatric patients." MEDICAL MYSTERY The discovery of NSIAD began in 2003 after two unrelated baby boys, each about three months old, were referred to...

Fluorescing lab worms signal longer life spans

...aboratory nematodes known as C. elegans, the study indicated the brightness level triggered by the reporter protein could predict up to a four-fold variation in the life expectancy of a worm. In a typical experiment, the brightest worms had life expectancies of about 16 days, compared to about three days for t...

Scientists track stealth DNA elements in primate evolution

...mately 18-25 million years ago. Their results also indicated that the AluYb subfamily underwent a major species...me. However, prior evidence from the Ya5 subfamily indicated that at least some "master" Alu elements may persist in low-copy numbers for long periods of evoluti...

Gambling monkeys give insight into neural machinery of risk

...he said. Further analysis of the neuronal activity indicated that, indeed, the neurons were reflecting the risk value the monkeys placed on the target, rather than an after-the-fact response to the payoff. While Platt and McCoy believed they have isolated one component of the neural machinery of risk, they do...

Elderly mice yield clues to the process of growing old

... mutations. Instead, the group found evidence that indicated accelerated cell death, especially in tissues characterized by rapid turnover of cells, occurred as mutations mounted in the mitochondrial DNA. "We found no evidence of oxidative stress," Prolla explains. In fact, the team noted less oxidative stres...

One bacteria stops another on contact

...ork by Scott Hultrgen at Washington University has indicated that E. coli cells may hide in the walls of the bladder and urinary tract in a dormant state, explained Low. It is possible that the newly discovered CDI system contributes to this process. "By studying the CDI system, we hope to understand more abo...

Opiate cocktail may spare cells from morphine's dark side

...ing imbalances, and indeed past work from Whistler indicated that mutant versions of the receptor that are more...id not show tolerance. Moreover, past work has not indicated whether the promotion of MOP-receptor internalization could prevent the development of morphine depe...

Tadpole soon to help in the fight against cancer and lymphedema

...ir research, the research group op Peter Carmeliet indicated that tadpoles are extremely suitable for the study...ith the same coloration techniques the researchers indicated that the development of lymphatic vessels in tadpoles is comparable to mice and humans. A second par...

NYU chemists use computer simulation to enhance understanding of DNA transcription

...tional Academy of Sciences. Previous research has indicated that chromatin--a chromosome's substance consisting of histone proteins and DNA--exhibits salt-dependent conformations. Specifically, chains of nucleosomes, the building blocks of chromatin that appear as bead-like structures along DNA, fold into a c...

New study shows SARS can infect brain tissue

...tlessness and delirium. A computed tomography scan indicated brain damage. He died about a month after being hospitalized, and his brain tissue was examined and found to contain the SARS coronavirus. The researchers also discovered a high level of Mig, a type of immune system regulator called a chemokine, in t...

Freeze-dried mats of microbes awaken in Antarctic streambed

...ured variation in atmospheric carbon over decades, indicated the streambed had been dry for about 20 years. "After we diverted the water into the channel, photosynthesis began the same day and the mats became abundant within a week," she said. "This showed us that they had been preserved in a cryptobiotic sta...

Tissue regeneration operates differently than expected

...ther with skeletal or heart muscle cells. This was indicated by the green fluorescence of muscle cells derived from the fusion with a stem cell which before had been labelled with the green dye. In contrast, no green fluorescing muscle cells became evident when stem and muscle cells were spatially separated by...

Study findings offer potential new targets for antibiotics

...ositioned on the ribosomes. Interestingly, the map indicated that there were four additional places on ribosomes where these mutations clustered. While researchers already knew that these sites existed, they did not know that these areas could possibly become targets for antibiotics. These sites are what may ...

U-M scientists discover identifying markers for primitive blood-forming stem cells

...ptors were able to reconstitute indefinitely. This indicated that CD244+ cells were a marker for multipotent progenitor cells (MPPs), but not for hematopoietic stem cells. In a third step, the team tested another SLAM marker called CD48, and found it to be expressed only on more advanced cells. It was not pre...

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