Visceral Leishmaniasis: Successful Vaccine Trial In Dogs
...of 18 dogs included in the study were treated with increasing doses of protein antigens excreted by the parasite (that is 50, 100, 200 micrograms) made up to a formula with an adjuvant. The other six received no treatment. Two injections at an interval of three weeks resulted in infection of all the animals wit...Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models
...mer's usually begins after the age of 60, the risk increasing with age. ...'Underground' tunnels discovered as means for communication between immune system cells
...ens to reach other dendritic cells in lymph nodes, increasing the number of these cells capable of stimulating T lymphocytes," added Dr. Salter. The finding that nanotubules play a role in sending molecular signals to other immune system cells calls into question the long-held belief that immune system cells t...Opiate cocktail may spare cells from morphine's dark side
...development of drug tolerance, the requirement for increasing doses to maintain analgesic effect, and the development of physical dependence. In the June 7 issue of Current Biology, researchers report a new study showing that the administration of a drug cocktail containing morphine along with small doses of tw...Gaining ground in the race against antibiotic resistance
...cterial resistance enzyme and grew the bacteria on increasing concentrations of antibiotics, it took only a few days of test tube evolution to increase drug resistance. Eventually, they found four mutations in the evolved enzyme that allowed the bacteria to survive on a drug dose 64 times higher than the dose t...World-first technology enables study of ancient bacteria
...ssures (greater than 1,000 atmospheres), gradually increasing temperatures (from an icy 2°C to over 100°C), great depth (several kilometres) and age (many millions of years) may contain most of the bacteria on Earth. Some of these bacteria produce methane that accumulates in "gas hydrates" ?a super concentrate...Global warming increases oyster sensitivity to pollution
...ge of mitochondria in cadmium-exposed oysters with increasing temperature", Lannig explains, "these organelles b...ia at lower temperature become strongly toxic with increasing temperature." Cadmium circulates continually between air, water and soils. As it moves easily throu...WCS says avian flu prevention should focus on farms, markets
...mal health by limiting contact with wild birds and increasing surveillance for the virus on poultry farms. ...Nanotubes inspire new technique for healing broken bones
...roups improve the biocompatibility of nanotubes by increasing their solubility in water. "Researchers today are realizing that mechanical mimicry of any material alone cannot succeed in duplicating the intricacies of the human body," Haddon says. "Interactions of these artificial materials with the systems of ...Genes linked to treatment resistance in children with leukemia
...at are not affected by these particular enzymes or increasing the dosage of drugs that are. And, in the future, a simple blood test may be all that's needed to make that determination. "This research showcases a new direction for cancer treatment ?personalized chemotherapy based on the genetics of the patient,...Einstein researchers identify new way that bacteria develop resistance to antibiotics
...loping resistance to fluoroquinolones due to their increasing use in treating multi-drug-resistant TB infections. Until recently, this resistance was due entirely to mutations in DNA gyrase that prevent fluoroquinolones from binding to the complex formed by the enzyme and DNA. Now, the Science article has iden...Enzyme affects hypertension by controlling salt levels in body
...rcent of salt, too much salt returns to the blood, increasing blood volume and leading to hypertension. If less than 99 percent is absorbed, low blood pressure develops. Dr. Huang said that not everyone who eats too much salt ends up with hypertension, but some population groups, such as African-Americans, are...Aquatic plants may hold key to advancing plant disease management
...d. "Global warming and climate change appear to be increasing the rate at which these diseases spread and intensify," he said. The biology, ecology, and control of aquatic plant diseases in freshwater and marine environments will be addressed during the Aquatic Plant Pathology symposium at the APS Annual Meeti...Freeze-dried mats of microbes awaken in Antarctic streambed
...at a higher rate than mats in adjacent streambeds, increasing biomass productivity, she said. As photosynthetic bacteria, cyanobacteria are believed by biologists to be among the first living organisms to colonize Earth. The mats generally are orange or black and consist of 10 to 15 different species of cyanoba...Lactose intolerance linked to ancestral environment
...also found that lactose intolerance decreases with increasing latitude and increases with rising temperature, and especially with the difficulty in maintaining dairy herds safely and economically. A major challenge in interpreting the data, Sherman noted, was to resolve the puzzle that about 13 lactose-toleran...MSKCC researchers uncover structure of key protein complex in cells
...d a "mysterious cousin" of ubiquitin, a protein of increasing interest to cancer experts. The two molecules have remarkably similar structures, though they perform different tasks in cells. Ubiquitin acts as a chemical tattoo that marks damaged or obsolete proteins for destruction by a protein complex in the c...Experimental shingles vaccine proves effective in nationwide study
...hough not all will. The two major risk factors are increasing age and declining immunity. Half of all people who live to age 85 will get the disease. Experts estimate more than a million new cases of shingles occur in the United States each year. The trial was conducted at 22 study sites nationwide, including ...Researchers find ways to turn manure into power
...ther trends contributing to a potential excess are increasing imports of grain-based nutrients to feed the cattle; less irrigation water; and the switch to crops which use less water and require fewer nutrients. "Things are in reasonable shape now, but in 10, 20 or 30 years from now, we need to have alternate ...'Patient-choice' C-section rate rises 36%: HealthGrades study
...go, we found that 'patient-choice' C-sections were increasing at a rate of 19 percent, between 1999 and 2001," continued Dr. Collier. "Now we are seeing the rate increase by 36.6 percent between 2001 and 2003, a dramatic acceleration that we believe is driven by heightened awareness of the option, increased sup......vel approach to treating bacterial infection is by increasing the killing capacity of cells of the innate immune system. In a related commentary, Kol Zarember and Harry Melach write, "By dissecting the role of HIF-1 in innate immune defenses, the study…introduces new targets for therapeutic immunomodulation." ...