NYU and MSKCC research provides model for understanding chemically induced cancer initiation
...d DNA repair. Many different chemical carcinogens, including those that are primary components of cigarette smo...tov. "Because environmental chemical carcinogens, including those present in cigarette smoke, are a significant threat to human health, it is imperative to unde...Plant Sacrifices Cells to Fight Invaders
...ated molecular responses. Such defense mechanisms, including PCD, are similar to immune responses exhibited by ...plays a critical role in many biological processes including immune system function, embryonic development and elimination of defective cells. When PCD malfuncti...A little stress gives beneficial oomph! to immune system
...neath the skin on the backs of all of the animals, including the mice in the non-stressed group. These disc-shaped sponges were about the size of a grain of rice. Sponges were removed from some of the mice six hours after implantation and from the rest of the mice one, two or three days later. The researchers...NIAID begins clinical trial of West Nile virus vaccine
... been tested successfully in a variety of animals, including mice, horses and American crows. Two other human WNV vaccines developed with NIAID support are currently in Phase I clinical trials. Called chimeric vaccines, these vaccines combine genes of the West Nile virus with genes of a closely related virus-...Advancements In Genomics Foster Deep Sea Discoveries
...r a variety of research outside of the deep ocean, including the application of deep sea bacterial genes for im...ntalizing discoveries in Photobacterium profundum, including a novel fermentative process, adaptations to electron, proton and nutrient transport across membrane...One gene links newborn neurons with those that die in diseases such as Alzheimer's
...e tissue. When the film is lifted, the cell body - including its RNA - comes with it, as if removed by a hole punch. After collecting, purifying, and amplifying the RNA from 3,500 cells for each bird, the researchers used a microarray created in the lab to find out which of the genes in the cells were turned ...Oceans more vulnerable to agricultural runoff than previously thought, study finds
... other vulnerable subtropical and tropical oceans, including Southeast Asia, West Africa, the Arabian Sea and the Bay of Bengal. "Now we can go back and predict which areas of the world will be vulnerable in the same way the Gulf of California is to nutrients coming off the land," Matson said. "Inarguably, th...Compounds in plastic packaging act as environmental estrogens altering breast genes
...ses to tableware and food and beverage containers, including baby bottles. BBP (n-butyl benzyl phthalate) is a ...regulating cell proliferation and differentiation, including tumor-suppressing proteins and a large number of unknown proteins. The exception was decreased expre...NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
...ouse models to explore the role of genes and diet, including the finding that inactivation of the p21 gene acce..." says Yang. "We are testing this concept further, including exactly how the p21 gene gets activated." ...Doctors closer to using gene analysis to help trauma patients
... of Sciences, researchers from eight institutions, including the University of Florida, describe how they were ...nding of the body’s molecular reactions to injury, including inflammation. The lead research author is Dr. J. Perren Cobb, an associate professor of surgery at W...Red delicious, Northern Spy apples have most antioxidants, chemists find
...umber of other apples popular in the United States including Gala, Granny Smith, Jonathan, York, Stayman and Rome. All of the apples used in the study were grown on the same farm under similar conditions. The researchers found: * Polyphenols were five times more prevalent in the skin than the flesh of the app...Putting ecology back into river restoration
... is critical that the broad restoration community, including funding agencies, practitioners and citizen restoration groups, adopt criteria for defining and assessing ecological success in restoration. Standards are needed because progress in the science and practice of river restoration has been hampered by t...Activation of thermoreceptors mediates raw garlic's burning pungency
...d by temperature and chemicals. Some TRP channels, including TRPA1 and TRPV1, respond to both temperature and chemical compounds: TRPV1 is known to respond to noxious (painful) heat and to the pungent component of chili peppers, whereas TRPA1 is activated by noxious cold and by pungent compounds found in cinna...Oldest fossil human protein ever sequenced
...racting and sequencing protein from other fossils, including earlier humans, as a means of determining the relationships between extinct and living species, and to better understand the phylogenetic relationships. ...FDA Warns About Antipsychotic Drugs and Elderly
...effects of all atypical antipsychotic medications, including those that have not been studied in the dementia population. The agency is considering adding a warning to the labeling of older antipsychotic medications because limited data also suggest a similar increase in mortality for these drugs. The review ...Secret of smallpox's success may lead to bioterror cure
...tool for fighting a host of other viral pathogens, including HIV. Jacobs has received a $1 million grant from ...he immune system begins a complex immune response, including developing antigens that specifically target the virus. Because the virus's double-stranded RNA sign...Disease progression model of pancreatic cancer developed by Penn researchers
...tability is seen in many human epithelial cancers, including pancreatic cancer, and is thought to be a driving force in the transition from local tumor growth to metastases of cancers. According to Hingorani, "This model may prove useful to understanding human pancreatic and other epithelial cancers because th...Basis for DNA ejection from single phage particles
...ferent from that found in most eukaryotic viruses, including those that infect humans, in that the envelope of these viruses fuses with the host plasma membrane so that the genome is delivered without directly contacting the membrane. Phage nucleic acid transport poses a fascinating biophysical problem: Trans...Researchers make surprise discovery that some neurons can transmit three signals at once
...pplications several questions need to be answered, including how GABA, glycine and glutamate synapses cooperate to activate NMDA receptors. In the traditional sense, when inhibitory synapses are mature, they would never release glutamate, nor would they be able to depolarize a cell, both of which are required ...