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Found: Missing sequence of the human Y chromosome

... an extraordinary abundance of repetitiveelements, including transposons and tandem arrays of satellitesequence...fines approximately two-thirdsof the Y chromosome, including a section spanning the centromere. Suchrepetitive sequences, although not recalcitrant to cloning, a...

Marburg virus disease in Angola - update

...revention (CDC), Atlanta, USA. The team from WHO, including experts from the Inter-country programme for southern Africa, the Regional Office for Africa (AFRO) and from Headquarters, and partners in the Global Outbreak Alert and Response Network (GOARN) are supporting the Ministry of Health, Angola to strengt...

Emory Eye Center Implants Its First Retinal Chips In Patients With Retinitis Pigmentosa

...ye Center and the VA Rehabilitation R&D Center including Ronald A. Schuchard, PhD and Claire Barnes, PhD. "This clinical trial will help evaluate the potential of Optobionics' ASR® device to provide improved functional vision or to at least slow down the progressive vision loss" says Dr. Schuchard, princi...

Leukemia Drug Breakthrough Study In New England Journal Of Medicine

...bnormality may be linked to other serious cancers, including leukemias and small cell lung cancer. In another finding of the same study, all the patients with the 5q deletion who became transfusion independent also went into cytogenetic remission, meaning that the chromosome abnormality disappeared. List, a ...

Mitochondrial DNA mutations play significant role in prostate cancer

...e cancer patients andfound a variety of mutations, including various mutations in the mtDNAcytochrome oxidase subunit (COI) gene. They then sequenced the COI gene in 260 prostate cancer tissue samplesor blood cells from patients with confirmed cancer who had undergoneradical prostatectomies between 1995 and 2...

Antibiotic Resistant Bacterium Uses Sonar-like Strategy to “See?Enemies or Prey

...ococcus produce a toxin that destroys other cells, including humancells and even other types of bacteria. They also knew that this toxinwas made only under some conditions. Until Gilmore’s study, scientistswere unable to explain how the Enterococcus knew when to make it.In the Science study, Gilmore and his te...

Molecular machine may lead to new drugs to combat human diseases

... human diseases, however, do have Group I introns, including the HIV opportunistic infections pneumocystis, a form of pneumonia, and thrush, an infection of tissues in the oral cavity. This makes introns a potential target for therapeutics against these diseases by using a strategy called targeted trans-splici...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

...d cat allergen into the windpipes of all the mice, including a control group that was not allergic to cats. GFD damped asthma-like and other allergic reactions in the cat-allergic mice: reactions in the mice that received GFD were similar to the control group mice that were not allergic to cats. The molecule ...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

...llular processes thatare common among all animals, including humans.Reinisch and her colleagues collected surf clam eggs and sperm,fertilized them in vitro, and added BCE to normally developing clamembryos. The investigators used a combination of antibodies and dyes toshow the presence of neurotransmitters in ...

Female sex hormones play a vital role in defense against sexually transmitted diseases

...susceptibility to sexually transmitted infections, including HIV-1 and HSV-2. We do not understand why, and our hope is that by doing these kind of mouse studies, we can understand the mechanisms." In the first study, female mice received either the hormone estradiol or progesterone, a combination of both, or...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

...llular processes thatare common among all animals, including humans.Reinisch and her colleagues collected surf clam eggs and sperm,fertilized them in vitro, and added BCE to normally developing clamembryos. The investigators used a combination of antibodies and dyes toshow the presence of neurotransmitters in ...

Muscle-targeted gene therapy reverses rare muscular dystrophy in mice

...glycogen builds up in muscles throughout the body, including the heart, causing muscles to degenerate. Using genetically altered mice in which the gene for the enzyme had been rendered nonfunctional, the researchers demonstrated they could introduce the functioning gene and correct glycogen buildup in heart a...

Scientists decipher genome of fungus that can cause life-threatening infections

... new genes likely involved incapsule biosynthesis, including a family containing 7 members of thecapsule associ...o isolates. A combination ofother factors ?perhaps including the cumulative impact of small(single-nucleotide) DNA differences and differences in when the genesa...

Purdue proves concept of using nano-materials for drug discovery

... discovery of new drugs for a variety of diseases, including cancer. The researchers created a chip about one centimeter square that holds thousands of tiny vessels sitting on top of a material that contains numerous pores. This "nanoporous" material makes it possible to carry out reactions inside the vessels...

In the sea slug's defense against lobsters, confusion is key

...on also stimulates other behaviors in the lobster, including grooming and avoidance. Ironically, the slug's ability to trick the lobster's nervous system into activating feeding-associated behaviors succeeds, in combination with ink and opaline's other effects, in distracting the lobster sufficiently to enable...

Essential mangrove forest threatened by cryptic ecological degradation

...stration (NOAA). Drawing on diverse data sources, including assessment of contemporary mangrove assemblages in southern Sri Lanka, changing water runoff patterns, and archival material from the Dutch East-India company, the researchers show that over the past few decades contemporary irrigation projects have ...

U-M scientists find genes that control growth of common skin cancer

...a number of different humandiseases and neoplasms, including BCCs in skin and cancers arising inbrain, lung, prostate, pancreas and other gastrointestinal organs.Dlugosz and colleagues focused on the function of uncontrolled Hhpathway signaling in the growth of BCC.The investigators used genetically engineered...

Weill Cornell Research Reveals Secrets Of Trafficking Within Cells

...e role of some of the key players in this process, including a ubiquitous protein called clathrin, found in nea... broad implications for cells throughout the body, including those closely tied to brain disorders, cardiac illness, and other major conditions. He pointed out ...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

...o study the human genome in an unbiased fashion -- including regions that have historically been termed coding ...e entire human genome and several model organisms, including Drosophila, Arabidopsis, S. cerevisiae and S. pombe. Further Information: Using GeneChip(R) techn...

Taking Aim With Nanoparticle PEBBLEs

...orators have been doing over the past seven years, including encouraging preliminary results using PEBBLEs to treat a virulent form of brain cancer in rats. PEBBLEs are polymer spheres, typically 20 to 200 nanometers in diameter—about the size of a virus. The spheres carry an assortment of molecules on their ...

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