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A gene's first 'kiss' sets off that affair known as puberty

...me, produces puberty's tell-tale physical changes, including the development of breasts in girls and voice change in boys. As such, this research begins to answer one of the most vexing questions about human development: What causes puberty to begin? How is it that the full repertoire of reproductive hormones ...

Chemists create 'Superbowl' molecule; May lead to better health

...ws promise for a wide range of other applications, including the removal of environmental toxins and aiding in ...y chemists for their wide range of potential uses, including drug delivery, chemical synthesis and as models for cell and viral behavior. Until now, these molecu...

Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer

...erapy alone. In addition, long-term toxic effects, including cardiac deaths, were acceptable for both groups of patients. "Our results, and those from other groups, confirm that in situations where residual disease remains, adjuvant chemotherapy alone in high-risk breast cancer patients is suboptimal and that...

Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down

...erapy alone. In addition, long-term toxic effects, including cardiac deaths, were acceptable for both groups of patients. "Our results, and those from other groups, confirm that in situations where residual disease remains, adjuvant chemotherapy alone in high-risk breast cancer patients is suboptimal and that...

Molecular biology fills gaps in knowledge of bat evolution

...heir origins and divergence. Now, a research team including University of California, Riverside Biology Professor Mark Springer, has published a paper in the Jan. 28 issue of the journal Science that uses molecular biology and the fossil data to fill in many of the gaps. Springer coauthors the paper, titled ...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...o-activator that was isolated in 2002. Experiments including the measurement of gene activity by microarrays showed that saturated and trans fats caused greater activity of the gene that makes PGC-1beta co-activator than did unsaturated fats. The research also showed that when the fats triggered PGC-1beta, th...

Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer

...ls over thecourse of evolution.Thus, most mammals, including humans, can only repair these lesionsthrough a much less direct and elaborate process called nucleotideexcision repair.In the new work, Dr. Bert van der Horst and colleagues studied theeffects of CPD and 6-4PP lesions by providing mice with transgene...

It's not all genetic: Common epigenetic problem doubles cancer risk in mice

...nt or just in its progression. "Most researchers, including me, expect epigenetic differences to influence pro... the impact of colon cancer prevention strategies, including dietary interventions and targeted drugs. ...

Priming embryonic stem cells to fulfill their promise

...ia.Scientists have identified about 100 proteins - including laminin,fibronectin, and several kinds of collagen - that function as theextracellular matrix, or scaffolding, of most mammalian tissues. Untilnow, there has been no practical way to evaluate the daunting number ofpossible combinations of these prote...

New binding target for oncogenic viral protein

...at protect cells against malignant transformation, including tumor suppressor proteins p53 and pRb. In the Journal of Biological Chemistry paper, Dr. Welcker and Dr. Bruce Clurman report that T antigen also binds to another tumor suppressor, Fbw7. This protein is part of a ubiquitin ligase complex that adds u...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...ed to pay special attention to prevention tactics, including exercise and weight control to minimize insulin resistance -- the other major factor involved in triggering type 2 diabetes. "In particular, someone who was a low-birth-weight baby can compound the risk of developing diabetes by becoming overweight,...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

...y, GM-CSF is approved by the FDA for several uses, including incancer patients to increase the number of white blood cells to fightinfection after chemotherapy; in healthy individuals serving as bonemarrow donors to stimulate the bone marrow to release stem cells; andin patients who have had a bone marrow tran...

Current human embryonic stem cell lines contaminated UCSD/Salk team finds

...ryonic stemcells include animal-derived materials, including connective tissuecells (so-called "feeder layers") from mice and fetal calf serum."The human embryonic stem cells remained contaminated by Neu5Gc evenwhen grown in special culture conditions with commercially availableserum replacements, apparently b...

Elusive HIV shape change revealed; Key clue to how virus infects cells

...They surmounted considerable technical challenges, including difficulty in getting gp120 to form good crystals. "Without very well-ordered crystals you get a very blurry picture," explains Harrison. "It took a very long time, and lots of computational work, to get that picture to sharpen up enough to get an a...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...rs after diagnosis despite treatment. Scientists, including Drs. Chiorazzi, Rai and others at North Shore-LIJ, as well as other research groups in Bethesda, MD, San Diego, CA, and Barcelona, Spain, have identified genetic and protein markers that can predict whether a CLL patient will follow the benign or agg...

Ecological destruction fuels emerging diseases

...n estimated 250,000 species of plants and animals, including everything from viruses to jaguars. For his part, Dr. Brooks has looked for parasites in more than 4,000 individuals from species ranging from frogs to deer. So far, he has found more than 5,000 different types of these often microscopic hangers-on ...

A much-needed shot in the arm for HIV vaccine development

...an reads like a "who's who" of globalAIDS experts, including Anthony S. Fauci, Director of the NationalInstitut...op AIDS vaccine funding andadvocacy organizations, including the Bill & Melinda GatesFoundation, the US National Institutes of Health, the InternationalAIDS ...

Inexpensive, mass-produced genes core of synthetic biology advances at UH

...new generations of vaccines and therapeuticagents, including vaccines for HIV and other viral diseases. Thistechnology also will facilitate development of new medications throughthe creation of humanized yet synthetic antibodies that could beespecially useful in detection and treatment of infectious organismst...

New Technique for Tracking Gene Regulators

...dentified some 6,302genome-binding sites for CREB, including many that are located nearknown genes. Genes identified as being regulated by CREB using thismethod include the gene responsible for causing Huntington’s disease inmice, which is important for making advances in understandingHuntington’s disease in h...

Breakthrough Microarray-based Technology for the Study of Cancer

...CGH),which undergoes dramatic chromosomal changes, including loss,duplication and the translocation of DNA from one chromosome toanother, as cancer develops. Understanding these changes is key tounderstanding cancer progression as well as developing possibletherapies and prognostic and diagnostic tools."Genomi...

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Breaking Medicine News(10 mins):Health News:AvePoint Enhances Workforce Productivity and Document Protection on Microsoft Office 365 with the Release of Three New Apps 2Health News:AvePoint Enhances Workforce Productivity and Document Protection on Microsoft Office 365 with the Release of Three New Apps 3Health News:AvePoint Enhances Workforce Productivity and Document Protection on Microsoft Office 365 with the Release of Three New Apps 4Health News:Intellitec Solutions to Host Microsoft CRM 2015 Update Webinar 2Health News:Medflow Launches MEDFLOW 2.0 EHR – The Cloud-Based Ophthalmology EHR 2Health News:Curly Hair Solutions™ Showcases Entire Curl Keeper™ Collection at Cosmoprof Las Vegas July 12 - 14 2Health News:Gov. Mark Parkinson, President and CEO of AHCA/NCAL to Give Keynote Address at Harmony 2015 2Health News:Gov. Mark Parkinson, President and CEO of AHCA/NCAL to Give Keynote Address at Harmony 2015 3
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