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Tag: "implicated" at biology news

UCSB scientists probe sea floor venting to gain understanding of early life on Earth

... greatest biomass on the planet. They are strongly implicated as the earliest life here and perhaps elsewhere." The direct linkages between life and planetary processes on the volcanically active, deep-sea, mid-ocean ridge system can only be understood through tightly integrated studies across a broad range of...

Drug That 'Tags' Decision-making Areas Of The Brain May Aid

... attaches only to areas of the brain that havebeen implicated in nicotine addiction may help studies of people ...receptors elicitsdopamine in various brain regions implicated in nicotine addiction andother disorders. Nicotine acts by opening specific membrane proteins,called...

Genome-wide mouse study yields link to human leukemia

...or suppressor gene and a unique chemical signature implicated in the development of human leukemia, findings that open up a "treasure box" of opportunity and possibility, study authors say. Researchers in The Ohio State University Comprehensive Cancer Center bred a type of mouse that develops acute lymphoblast...

Found: Missing sequence of the human Y chromosome

...ntains eight putatively active genes that could be implicated insex-associated height differences and gonadal tumor development. Thispericentromeric gap was one of the few holes remaining in the"finished" sequence of the human genome reported last October by theInternational Human Genome Sequencing Consortium....

Gene variations explain drug dose required to control seizures

...f both carbamazepine and phenytoin. SCN1A has been implicated in many inherited forms of epilepsy and is the drug target for phenytoin. Given its relationship to both anti-epileptic drugs tested, the SCN1A variant may be of particular importance for understanding patient response to drug treatment, said the re...

Researchers identify target for cancer drugs

...l. Abnormally high activation of Akt has long been implicated in a variety of cancers. If Akt travels to the cell membrane, it is switched on and promotes cell division, often contributing to tumor growth as a result. However, as long as it stays within the cell cytoplasm, it remains relatively inactive. That's...

U-M scientists find genes that control growth of common skin cancer

...in normal development,and its dysfunction has been implicated in a number of different humandiseases and neoplasms, including BCCs in skin and cancers arising inbrain, lung, prostate, pancreas and other gastrointestinal organs.Dlugosz and colleagues focused on the function of uncontrolled Hhpathway signaling in...

Critical role in programmed cell death identified

...g and targeting a process vital to development and implicated in cancer and autoimmune diseases. The work, repo...other complications. "Mammalian studies that have implicated mitochondrial fragmentation in cell death have been done under rather artificial conditions, in tiss...

Study of genomic DNA leads to new advances in cancer diagnostics

...as sensitive or resistant to Alu I. The group also implicated the cell's cytoskeleton, the internal scaffolding that gives the cell its shape, in this process. Changes to the ECM and cytoskeleton are critical to migration of a cancer cell from one site in the body to another. The researchers could alter the Al...

Unexpressed But Indispensable -- The DNA Sequences That Control Development

...clusters, most of them in close proximity to genes implicated in transcriptional regulation or development. This clustering of CNEs suggests they may not only attract transcription factors, but may also influence the local topology of the DNA, thereby controlling access to their associated gene. Several cluster...

Antibiotic might fight HIV-induced neurological problems

... involve two specific proteins -- MCP-1 and p38 -- implicated in damage in neurodegenerative diseases. The MCP-1 protein, when secreted from brain cells under attack from HIV or SIV, attracts infection-fighting cells known as macrophages, which then enter the brain. The influx of these cells contributes to swe...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...es. For example, prenatal viral infection has been implicated in schizophrenia, autism and cerebral palsy; bacterial infection is a risk factor for Parkinson's disease. Up to 20 percent of pregnancies have complications involving infections of the uterus and its contents, a number that will rise as more childre...

Live fast, die young true for forests too

...h. Atmospheric carbon dioxide, a heat-trapping gas implicated in climatic warming, increases as carbon storage in forests decreases, and decreases as carbon storage in forests increases. Information regarding such potential changes is therefore needed to reduce uncertainties in predicting future climatic change...

Products containing specific probes for detecting alternative splice forms protected

... functions from a single gene. Splicing events are implicated in numerous pathologies and can be altered by various stress events such as virus, toxic agents, and drug exposure. The genome-wide patented probe configuration described in the patent is the basis for the microarrays in ExonHit's SpliceArray produc...

Researchers rein in regulatory RNAs

... least 8% of human genes. Many SAT pairs have been implicated in various stages of gene regulation, including transcription, mRNA processing, splicing, stability, transport, and translation. Various examples of such overlapping genes have been documented in all life forms ?from viruses and prokaryotes to plants...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

...gene expression in neighboring glial cells is also implicated in motor neuron death. Lead author Cedric Raoul and colleagues targeted the cause of the disease by using RNA interference to silence the defective gene, preventing it from expressing the SOD1 protein. RNA interference is part of a complex cellular...

Two are better than one

...tenna-like on the outside of the cell wall and are implicated in certain types of cancer. A team of researchers under Prof. Yosef Yarden, Dean of the Weizmann Institute's Feinberg Graduate School and a professor in the Institute's Biological Regulation Department, had previously found that, under certain condit...

New understanding of DNA repair may pave way to cancer treatments

...the first time we've seen a protein which has been implicated in gene regulation possess an independent function--in DNA repair--while both functions are uncoupled from one another," said Ronai. Dr. Ronai's laboratory has been studying ATF2 with the goal of understanding its role in regulation of cell cycle and...

Brain-injury rehabilitation depends on acetylcholine circuitry

...oradrenalin, dopamine, or serotonin have also been implicated in cortical plasticity and may also be manipulated to aid recovery after such injury. Publishing in Neuron, Volume 46, Number 2, April 21, 2005, pages 173?79. http://www.neuron.org ...

Signs of aging: Scientists evaluate genes associated with longevity

...tailed study to elucidate gene-expression patterns implicated in the aging process. Their results appear online today in the journal Genome Research. Led by Dr. Angela Brooks-Wilson, Senior Scientist at the BC Cancer Agency's Genome Sciences Centre, and Dr. Donald Riddle, Professor of Biology at the University...

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