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Tag: "impairs" at biology news

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...the researchers found that poor prenatal nutrition impairs the pancreas's ability to later secrete enough insulin in response to blood glucose. "The bottom line is that if you don't have delivery of enough nutrients from the mother to the baby, the baby's pancreatic cells will be programmed abnormally," sai...

Protein prevents detrimental immune effects of bacterial sepsis

...mune response: its expression on white blood cells impairs their ability to bind blood vessel walls, preventing their transit from the blood to other organs. When normal mice were treated with LPS, the immune system induced a steady migration of white blood cells from the blood into affected tissues. Howeve...

Stem cell treatment improves mobility after spinal cord injury

...perienced a partial injury to the spinal cord that impairs walking ability -- one group seven days after injury and another 10 months after injury. In both groups, the early-stage cells formed into full-grown oligodendrocyte cells and migrated to appropriate neuronal sites within the spinal cord. In the rat...

Scientists uncover new clues about brain function in human behavior

...ow from animal studies that damage to the amygdala impairs social functioning. "Social interactions are central to human experience and well-being, and are adversely affected in psychiatric illness. This may be the first study to identify functional disturbances in a brain pathway associated with abnormal s...

Optimizing cell therapy against tumors is a balancing ACT

...n of full effector function in vitro paradoxically impairs the in vivo anti-tumor efficacy of adoptively transferred CD8+ T cells TITLE: Towards improved immunocompetence of adoptively transferred CD8+ T cells ...

Scientists pinpoint inflammation gene

...e in a cell. People with a genetic variation that impairs SEPS1' ability to purify the cells by clearing out the bad proteins tend to suffer higher levels of inflammation than people in whom the gene fulfills that role more efficiently, according to the study. The study found the same relationship between...

Phenolic compounds may explain Mediterranean diet benefits

...ss controversy about whether olive oil benefits or impairs blood vessel health. "One of the beauties of this study is that using a randomized, sequential, crossover study, so that the same patients were exposed to the same oil, once with low phenolic content and the other with high phenolic content, the onl...

Driver of anthrax toxicity could lead to late-stage therapy

...esponsible for the toxic effects and swelling that impairs the host's immune response. In the current study, the researchers inactivated genes randomly in human cells. They then examined the mutated cells for resistance to anthrax toxin in an effort to identify host genes that have important roles in infec...

Study by Einstein researchers could lead to a novel strategy for treating obesity

...ing malonyl-CoA levels in this region of the brain impairs the nutrient-sensing mechanism by which the hypothalamus modulates food intake to maintain normal weight," says Dr. Rossetti, who is also the Judy R. and Alfred A. Rosenberg Professor of Diabetes Research at Einstein. "Figuring out a way to re-adjust...

How can we protect patients with weakened immune systems from influenza?

...n syndrome, a congenital multisystem disorder that impairs the immune system. Children's Hospital is a world leader in studying and treating this syndrome. Three projects involving adults are led by researchers in the University of Pennsylvania Health System. Two projects involve cancer patients: those rece...

Scientists discover a new disease-causing bacterium in an immune-compromised patient

...matous disease (CGD), a rare genetic disorder that impairs the immune system. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death. The journal also published an editorial entitled, "Extending the Spectrum of Human Pathogens," which comments on the signific...

Soil-bound prions that cause CWD remain infectious

...matous disease (CGD), a rare genetic disorder that impairs the immune system. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death. The journal also published an editorial entitled, "Extending the Spectrum of Human Pathogens," which comments on the signific...

Losing sleep undoes the rejuvenating effects new learning has on the brain

...ions by getting less sleep. But sleep deprivation impairs spatial learning -- including remembering how to g...rm from firsthand experience -- that lack of sleep impairs cognitive function. Sleep-restricted individuals have a shorter attention span, impaired memory, and...

A clue from macaques yields evidence for impaired retroviral defense genes in humans

... researchers found a single mutation in TRIM5 that impairs its ability to defend against retroviruses. This mutation occurs at a very high frequency in some ethnic groups, leading the authors to conclude that past periods in human history corresponding to relatively low levels of retroviral infections may ha...

Tramiprosate (Alzhemed? preclinical results published in Neurobiology of Aging

...tia associated with specific brain pathologies. It impairs a person's cognitive and motor functions, their activities of daily living, alters the behaviour and gradually destroys the brain. AD is the most common cause of dementia in our aging population. Almost 5 million individuals in the United States alo...

Honey helps problem wounds

...down the reproduction of malignant cells, but also impairs the healing process of wounds. 'Normally a skin injury heals in a week, with our children it often takes a month or more,' he says. Moreover, children with leukaemia have a weakened immune system. If a germ enters their bloodstream via a wound, the r...

Key to early diagnosis of autism may be in the placenta

...ger Syndrome, an ASD condition which, like autism, impairs the ability to relate to others. "By serendipity, at a dinner party I happened to sit next to George M. Anderson, a research scientist in the Yale Child Study Center who had access to many cases of children with ASD," said Kliman. "We realized that...

Adult stem cell research at UB targets damaged hearts

...es not occur in young persons). "If aging indeed impairs the function of these adult stem cells," said Lee, "genetic and tissue engineering might be used to boost the competency of aged MSCs." He noted also that mesenchymal stem cells do not appear to generate a strong immune response. "If this characte...

Bacterial protein shows promise in treating intestinal parasites

... or larval, stages and adult parasites, as well as impairs the excretion of eggs by female worms. Hookworms cause anemia by attaching to the intestine and feeding on their host's blood and nutrients, causing anemia and weight loss. The researchers said in their paper that because this naturally-produced p...

How does a zebrafish grow a new tail?

... the genes that are turned on by Wnt/Beta-catenin, impairs cell proliferation, and inhibits fin regeneration. Fish that have a mutant Wnt5b protein regenerate missing tails very quickly. Too much of another related protein, Wnt8, also increases cell proliferation in the regenerating fin. "We can actually i...

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