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Tag: "immunologists" at biology news

Genetic defects give the immune system the green light to attack the pancreas

...nd tolerate tissues that belong in the body, which immunologists call ‘tolerance,’?said Dr. Zucchelli. “Previous studies have shown that when the T-cells don’t learn this tolerance, they can infiltrate the pancreas and attack the insulin-producing beta cells.?This first step in the onset of type 1 diabetes is call...

Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage

...mmunity, Fox Chase Cancer Center scientists led by immunologists David L. Wiest, Ph.D. and Dietmar J. Kappes, Ph.D., show that cell-receptor signaling strength influences which course certain immature immune cells will take, suggesting a flexible new model for commitment to one lineage or another. The first, most...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

...hils or dendritic cells. These cells make up what immunologists call the "innate" immune system. They are the first to respond to a bacterial invasion. Their role is to rush to the infection site, engulf the bacteria, chew them up into smaller pieces and present those pieces to the T and B cells -- the "adaptive"...

Specialized immune-system B cells play double-barreled role

...nnate and acquired, Duke University Medical Center immunologists have discovered. The division of labor between B-1a and B-1b cells they have uncovered offers basic insights that could contribute to more rational development of vaccines, they said. B cells are the arms factories of the immune system, producing an...

New tool reveals secrets of migrating cells

...ualize cells in living tissues has changed the way immunologists think about how cells explore their environment, h...ton imaging three years ago surprised her and many immunologists because it showed that thymocytes or immature T cells were highly mobile, traveling thousands of mic...

Researchers seek to discover what really happens when a virus enters the body

...cal diagnostic thinking could be in jeopardy. As immunologists consider the relatively new concept, a new NIH grant, awarded to Amy Bell, an electrical and computer engineer (ECE), and Karen Duca, a research assistant professor at the Virginia Bioinformatics Institute (VBI), both of Virginia Tech, could answer s...

VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease

Virginia Commonwealth University immunologists studying mast cells, known to play a central role in asthma and allergic disease, have identified a hormone-like molecule that can kill these cells by programming them to die in studies with mice. The findings move researchers another step closer t...

Climate model links higher temperatures to prehistoric extinction

Virginia Commonwealth University immunologists studying mast cells, known to play a central role in asthma and allergic disease, have identified a hormone-like molecule that can kill these cells by programming them to die in studies with mice. The findings move researchers another step closer t...

Scientists directly view immune cells interacting to avert autoimmunity

...to authentically reproduce in vitro." The team of immunologists and diabetes researchers used the new microscope to show that when Treg cells are absent, the potentially destructive autoreactive T cells, known as T helper cells, swarm around the dendritic cells where they are primed to attack the body's own tissu...

Innovative movies show real-time immune-cell activity within tumors

...the tumor cells. Such molecules are referred to by immunologists as antigens. In a second group, no such vaccine was given. Movies captured with the two-photon microscope then recorded the unfolding scene in the so-called tumor microenvironment. How would the green T cells behave in the two groups of mice? "I...

Minuscule molecules pack a powerful punch

...evel of control in the immune system and will lead immunologists to rethink how the immune system works," said Dr Martin Turner, Head of the Laboratory of Lymphocyte Signalling and Development at the Babraham Institute. The deficits in response were significant: the knockout mice were less able to resist infect...

Molecule that destroys bone also protects it, new research shows

...mulate immunity. Gaffen noted that until recently, immunologists believed there were only two major types of "T helper" cells -- TH1 and TH2 -- which were believed to be responsible for nearly all immune system activities. "This paradigm underwent a sea change in 2005 with the discovery of a new type of T cell...

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