Gene therapy cures inherited liver disease in rats
...ike to see one developed that minimizes the body's immune response to it immediately right after it is injected into the body. "Fifteen years ago, the goal was to get some correction of the problem," he said. "Most effects were transient. Now with these vectors, long-term correction with no long-term toxic...Molecular fossils uncover link between viruses and the immune system
...ossils" also revealed that viruses and proteins of immune system share the same structure. One plausible exp...ved as precursors for the evolutionary more recent immune system of animals. These results are an outcome of recent advances in structural biology, a new dis...Gene keeps neural cells on correct developmental path
...ronal proteins produced by cancers may trigger the immune cells to attack the nervous system. The study focuses on a protein called REST, which is short for RE1-silencing transcription factor. It was independently discovered 10 years ago by Mandel's group and a second team led by HHMI investigator David J....Designing vaccines by computer
...periments to effectively trigger a response by the immune system. They look for common patterns in their seq...is needed for one of these fragments to trigger an immune response. They can then employ computers to search for similar sequences in the thousands of sequenc...Two chemicals boost immune cells' ability to fight HIV without gene therapy
...iscovered that two chemical compounds may help the immune systems of HIV-infected persons fight the disease ...icals activate telomerase -- a protein that boosts immune cells' ability to divide, enabling them to continue destroying HIV-infected cells. "The immune cell...Scientists generate patient-specific stem cells, Science study says
... and safety. Initial laboratory experiments showed immune system compatibility between the stem cell lines and the cells of people who supplied each line's nuclear DNA, suggesting that the patient's body might tolerate the cells after transplantation. The authors caution that work with human embryonic stem...SuperLigands - a database of ligand structures derived from the Protein Data Bank
... and safety. Initial laboratory experiments showed immune system compatibility between the stem cell lines and the cells of people who supplied each line's nuclear DNA, suggesting that the patient's body might tolerate the cells after transplantation. The authors caution that work with human embryonic stem...New strategies to reduce hospital-aquired infections
...threat to patients, especially those with weakened immune systems. By all accounts the prevalence of infections caused by some of the most potentially lethal waterborne microbes, such as legionella and pseudomonas, are underestimated." He explained that waterborne microbes- -bacteria, viruses, fungi and pa...Distributed Basic Local Alignment Search Toolkit (W.ND-BLAST)
...threat to patients, especially those with weakened immune systems. By all accounts the prevalence of infections caused by some of the most potentially lethal waterborne microbes, such as legionella and pseudomonas, are underestimated." He explained that waterborne microbes- -bacteria, viruses, fungi and pa...Wake Forest scientists find new combination vaccine effective against plague
...nia pestis, the bacterium that causes plague, "the immune mice survived but the control mice succumbed in th...tion ?produces little if any response in the mouse immune system. But if a protein termed flagellin is added to the vaccine, antibody levels against the plagu...Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights
Scientists have uncovered a new method the immune system uses to label foreign invaders as targets to be attacked. Researchers showed that the immune system can brand foreign proteins by chemically modifying their structure, and that these modificati...How A Latent Virus Eludes Immune Defenses
... virus to survive, it must elude the ever vigilant immune sentinels of its host. A latent virus can escape immune detection if it resides in nondividing cells and doesn’t produce any proteins. No viral proteins mea...Touching Molecules With Your Bare Hands
... virus to survive, it must elude the ever vigilant immune sentinels of its host. A latent virus can escape immune detection if it resides in nondividing cells and doesn’t produce any proteins. No viral proteins mea...Ancient immune defense mechanism is no match for HIV-1
...e of Immunity. RNA silencing is a type of natural immune defense in which sequence-specific RNA degradation follows the recognition of double-stranded RNA (dsRNA). The dsRNA is processed by a protein called Dicer, which chops the long strands of RNA into smaller pieces, resulting in the production of an RN...Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
The immune system is a marvel of versatility, creating a vari...ays to protect the body. To carry out these tasks, immune cells follow a career path that forks at various points in their development. In a report in the May...NHGRI targets 12 more organisms for genome sequencing
...W strain, often used in studies of transplants and immune response; the BB strain, used in studies of diabet...tions in this group of animals include an adaptive immune system similar to that of humans, a closed and pressurized circulatory system, and myelination of th...Bee mites suppress bee immunity, open door for viruses and bacteria
...olony deaths which includes suppression of the bee immune system by the mites. The Varroa destructor mite i... Cox-Foster looked at how bee mites affect the bee immune system. They injected heat-killed E. coli bacteria into virus-infected bees that were either infeste...Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes
...ansplants. They had expected rats that received no immune suppression would reject the transplants. Instead,...es their diabetes permanently without the need for immune suppression. The pig primordia are transplanted into the omentum, a membrane that envelopes the inte...Embryonic Stem Cells Treated With Growth Factor Reverse Hemophilia In Mice: UNC Researchers
...ited function, rejection of engrafted cells by the immune system and teratomas, tumors involving a mixture o...ft within the liver and were not recognized by the immune system as foreign. "Within a few weeks, PEPs became hepatocytes," Fair added. "They went from somet......eir ability to generate HIV-specific cell-mediated immune response to HIV, which is considered to be a key d...same antigen A in vector Y this time. In this way, immune reactions to, and the consequent inhibition of the transporter are reduced. The first injections pri...