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Tag: "immune" at biology news

Gene Signatures Predict Interferon Response For Multiple Sclerosis Patients

...unpredictable disease. It develops when the body's immune system attacks healthy nerve cells and disrupts no...associated with MS by correcting imbalances in the immune system that lead to disease. Interferon therapy produces changes in the gene expression profile of t...

Substance protects resilient staph bacteria

...the ability of PGA to promote resistance to innate immune defenses, learning more about the protein could le...ccal bacteria biofilms contribute to evading human immune defenses. Biofilms are protective cell-surface structures. Biofilm formation does not depend on PGA,...

Chemists identify immune system mechanism for methamphetamine binges

...have found evidence in laboratory studies that the immune system may be able to recognize methamphetamine an...mented the drug's apparent ability to suppress the immune system, making abusers more vulnerable to diseases such as HIV. The new study is the first to sugges...

Epstein-Barr virus protein crucial to its role in blood cancers

...ism by which EBV transforms human B cells from the immune system into cancerous cells, which can lead to development of B-cell lymphomas. Erle S. Robertson, PhD, Associate Professor of Microbiology and Director of Tumor Virology, with Penn's Abramson Cancer Center and MD/PhD student Jason Knight, published...

Defensins neutralize anthrax toxin

...ism by which EBV transforms human B cells from the immune system into cancerous cells, which can lead to development of B-cell lymphomas. Erle S. Robertson, PhD, Associate Professor of Microbiology and Director of Tumor Virology, with Penn's Abramson Cancer Center and MD/PhD student Jason Knight, published...

HIV vaccine trial breaks ground for future research

...y have been exposed frequently to HIV and a primed immune response, probably cellular or humoral, could have...the authors suggest that biological differences in immune response or genetic markers of resistance to infection could have made the vaccine more effective. ...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

... of these cancer risks with the use of HAART, with immune status, and with behavioral risk factors such as s... AIDS epidemic and how the knowledge of cancer and immune diseases has grown since it began. They note that questions remain about the types and severity of c...

Viral protein influences key cell-signaling pathway

...ng virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the ...aintains its lifelong infection and how the normal immune cells that "remember" a vaccination or an infection can survive for years or even decades. "The p30...

Gene Therapy Cures Inherited Liver Disease In Rats

...ike to see one developed that minimizes the body's immune response to it immediately right after it is injected into the body. "Fifteen years ago, the goal was to get some correction of the problem," he said. "Most effects were transient. Now with these vectors, long-term correction with no long-term toxic...

Multi-purpose protein regulates new protein synthesis and immune cell development

...signaling protein is required for the formation of immune cells called B lymphocytes. "This is a unique sig...mRNA. Other scientists have shown that XBP1 helps immune cells called B lymphocytes develop into antibody-generating plasma cells. Plasma cells secrete large...

Light therapy may combat fungal infections, new evidence suggests

..., most commonly in patients who lack a functioning immune system, such as organ transplant recipients, those with HIV/AIDS, and patients treated with steroids or cancer chemotherapy. The fungus' global importance as a health threat has therefore risen in parallel with the increase in immunosuppressive thera...

Computational Method Speeds Mapping of Cell Signaling Networks

... mapping a well-studied signaling network in human immune system T-cells. This feat originally took research...ut molecular "distress signals" that attract other immune system molecules to battle the infection. Components in the pathway are chemically altered during th...

New lab technique identifies high levels of pathogens in therapy pool

... very young children, the elderly and people whose immune systems are compromised. The pool attendants probably became ill because they were exposed to high levels of the pathogens by working consecutive, full days in the indoor pool environment. No patients became ill at the facility. The indoor pool wate...

Promising new West Nile therapy cures disease in mice

... antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus. The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease. "West Nile virus has emerged in the United States as a re...

Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis

... able to generate more specific cells, such as the immune cells known as B and T lymphocytes. In the Science study, Opferman's team genetically modified mice so that the gene for Mcl-1 could be specifically deleted from the genome of HSCs and progenitor cells. Upon genetic deletion, these mice developed an...

Researchers report new pro-inflammatory role for anti-inflammatory enzyme

Part of the immune system's pro-inflammatory response to bacterial in... Biochemistry and Molecular Biology journal. When immune cells are exposed to pro-inflammatory cytokines or bacterial endotoxin (part of the bacterial cell w...

Discovery may lead to better Candidiasis drug

... throat. It affects primarily people with weakened immune systems caused by antibiotics, chemotherapy or by ... check in persons with enough saliva and a healthy immune system, but they did not know precisely how histatin accomplished this. "There are many types of na...

Sickle cell and protection against malaria

...e gene for sickle cell haemoglobin may involve the immune system. Studying a group of children and adults in..., and previous work has suggested that there is an immune component to this protection. To discover whether the protection provided by HbAS is innate or vari...

White Blood Cell 'Waste Disposal' System Plays Critical Regulatory Role

...haracterized by abnormal numbers of these critical immune cells. Human neutrophils are white blood cells th...tion are not well understood, it is known that the immune signaling molecules IL-17 and G-CSF stimulate neutrophil production. In addition, a newly discovered...

Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells

Natural killer (NK) immune system cells can be genetically modified to brandi...chers were not able to grow large numbers of these immune cells in the laboratory, and because NK cells normally have only weak anti-leukemic activity. The k...

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