Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...ment of deficient, therapeutic proteins invokes an immune response that limits the efficacy of the treatment... the expression of introduced genes to muscle, the immune response can be prevented or attenuated." The muscle-targeted gene therapy might therefore apply to...Vital step in cellular migration described by UCSD medical researchers
...e body during growth, tissue repair and the body's immune response to invading pathogens, has been demonstra...ince cell migration plays an important role in the immune response, as leukocytes move toward targets, a therapy that stops that movement could potentially he...Discovery of key protein's shape could lead to improved bacterial pneumonia vaccine
...vaccine, these pieces ofcarbohydrate stimulate the immune system to make antibodies against thereal carbohyd...acteria. The problem with suchvaccines is that the immune systems of very young children (youngerthan two years) do not naturally respond to carbohydrates. Pn...New comparative toxicogenomics database
...vaccine, these pieces ofcarbohydrate stimulate the immune system to make antibodies against thereal carbohyd...acteria. The problem with suchvaccines is that the immune systems of very young children (youngerthan two years) do not naturally respond to carbohydrates. Pn...Taking Aim With Nanoparticle PEBBLEs
...motherapy drugs. "The really bad cancer cells get immune to chemotherapy drugs ?they pump the drugs back out," Kopelman said. Cancer cells can't do that to PEBBLEs, though, because PEBBLEs are already on the outside. Another advantage: the "killer oxygen" that PEBBLEs deliver to cancer cells is too unstabl...Genetically modified natural killer immune cells attack, kill leukemia cells
Natural killer (NK) immune system cells can be genetically modified to brandi...chers were not able to grow large numbers of these immune cells in the laboratory, and because NK cells normally have only weak anti-leukemic activity. The k...UCSD researchers maintain stem cells without contaminated animal feeder layers
...be transplanted into people, they would provoke an immune system attack eliminating their therapeutic value. While several laboratories have attempted to grow stem cells in alternative cultures, problems have remained. In some cases, human feeder layers were developed but this added another measure of comp...Gene Vaccine Protects Mice Against Development Of Her2/neu Breast Cancer
...uccessful animal studies, a novelvaccine that uses immune cells as factories to produce Her2/neu proteinmay ...s treatment“produces only a passive and transitory immune reaction,?Lachman said.“This vaccine, however, like many that treat microbial infections,appears to ...Highly adaptable genome in gut bacterium key to intestinal health
... causing a potentially damaging or disruptive host immune response. "B. theta is an incredibly sophisticated and versatile diner," says Justin Sonnenburg, Ph.D., W.M. Keck Foundation postdoctoral research scholar in the Center for Genome Sciences. "Instead of dying off when its usual source of food is gone...A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
...uccessful animal studies, a novelvaccine that uses immune cells as factories to produce Her2/neu proteinmay ...s treatment“produces only a passive and transitory immune reaction,?Lachman said.“This vaccine, however, like many that treat microbial infections,appears to ...Scientists reveal molecular secrets of the malaria parasite
...y the parasites to repulse the attack of thehost's immune system. * For the first time, scientists were able tostudy the protein expression of the parasite in the mosquito vector.Researchers hope this will shed light on how the mosquito and parasiteinteract, and perhaps will lead to new ways of controlling ...Studies reveal methods viruses use to sidestep immune system
... the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more ef...ial gene, called RIG-I, turns on a cascade of host immune defenses when the hepatitis C virus (HCV) replicates in cultured human cells. Those immune defenses...Research Gives Hope For Liver Damage
... first time, identifiedtwo separate populations of immune cells macrophages in the liver. Onegroup of macrophages causes scarring to the liver, but the next wave ofimmune cells, produced only a few days later, change function to breakdown and reabsorb the scarring. These findings, published in theJanuary ed...New SARS Protein Linked To Important Cell Doorway
...ld enable it to block proteins that help alert the immune system or to assist reproduced viral proteins as t...late into proteins that could help the virus avoid immune system attacks. He and his colleagues sought such sequences in portions of the virus' accessory geno...NYC's First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
...pathogenic, much more able to wreak havoc with his immune system, and medical providers and public health officials are being well-advised to work closely together to monitor -- and hopefully prevent transmission of -- this strain of the virus by encouraging gay men, in particular, to practice safer sex and...Jumping gene helps explain immune system's abilities
...."Hermes behaves more like the process used by the immune system torecognize a million different proteins, c...Hermes."Recognition of so many antigens allows the immune system to fightinfection and distinguish friend from foe. The "big picture" behindthis ability is th...UCSD Discovery Shows How Embryonic Stem Cells Perform 'Quality Control' Inspections
...."Hermes behaves more like the process used by the immune system torecognize a million different proteins, c...Hermes."Recognition of so many antigens allows the immune system to fightinfection and distinguish friend from foe. The "big picture" behindthis ability is th...NIAID Initiates Trial of Experimental Avian Flu Vaccine
...st the vaccine’s safety and ability to generate an immune response in 450 healthy adults aged 18 to 64. If the vaccine is shown to be safe in adults, there are plans to test it in other populations, such as the elderly and children. H5N1 avian influenza leads to severe disease in both birds and humans. Bet...New therapy for HIV/AIDS eliminates needles and excessive toxicity
...."Hermes behaves more like the process used by the immune system torecognize a million different proteins, c...Hermes."Recognition of so many antigens allows the immune system to fightinfection and distinguish friend from foe. The "big picture" behindthis ability is th......."Hermes behaves more like the process used by the immune system torecognize a million different proteins, c...Hermes."Recognition of so many antigens allows the immune system to fightinfection and distinguish friend from foe. The "big picture" behindthis ability is th...