Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals
... monitor gene expression in real-time. Because MRI images deep tissues non-invasively and at high resolution, investigators don't need to sacrifice animals and perform laborious and costly analysis. To trigger living cells into producing their own contrast agent, Ahrens gave them a gene that produces a for...X-Ray Beams And Fruit Fly 'Flight Simulator' Aid Scientists' View Of Muscle Power
... wing motion and enabled the team to capture X-ray images at different stages of muscle contraction. By combining the technologies, the researchers could reconstruct a ‘movie?of the molecular changes in the powerful muscles as they lengthen and shorten to drive the wings back and forth 200 times each second...... “right-handed?molecules, both of which are mirror images of each other. Only one of these molecules provides the therapeutic effect. In the production process, catalysts are used to selectively synthesize the preferred chiral molecule that provides for therapeutic treatment without undesired side-effects. ...First real-time view of developing neurons reveals surprises, say Stanford researchers
...that in the adult fish the neurons only respond to images moving in a certain direction or near the left or right side of the visual field. What they found was a surprise. As soon as the neurons were old enough to respond to the LCD screen, they specifically fired when they sensed only one type of movement...Taking Aim With Nanoparticle PEBBLEs
...ng molecules that make PEBBLEs more visible in MRI images provides an added bonus, helping to show where tum...e still alive and active two months later, and MRI images showed that their tumors had vanished. Kopelman and coworkers plan to tinker with the PEBBLEs a bit...Mouse brain tumors mimic those in human genetic disorder
... therefore may be promising drugtargets; and brain images often used to determine the need fortreatment may not actually be diagnostically informative. "Thesemice develop brain tumors with many of the same features as those seenin children with NF1, and studying those tumors has helped usunderstand the cel...Study identifies predictors of HIV drug resistance in patients beginning triple therapy
...hrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the em...einisch and company examined periodically recorded images to see whateffect, if any, the chemicals had. They also measured the levels ofproteins in the normal...Clam embryo study shows pollutant mixture adversely affects nerve cell development
...hrough the embryo," says Reinisch. The sequence of images yields athree-dimensional representation of the em...einisch and company examined periodically recorded images to see whateffect, if any, the chemicals had. They also measured the levels ofproteins in the normal......e the ability to process low-frequency sounds into images just as dolphins do with high frequency sounds, and they must have remarkable acoustic memories just as we have visual memories,?says Clark. Clark concludes that he and other researchers have been thinking about whale herds at the wrong scales, whic...The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
...ough a thin sheet of light, capturing high-quality images layer-by-layer. The sample can be rotated and view...ported post-processing step, one or more stacks of images are assembled into a high-resolution film. Another advantage of SPIM is that the specimen is kept a...Key molecule in plant photo-protection identified
...oducea dye that allowed Brendza to obtain detailed images of nerve cellbranches.To correlate brain cell changes with plaque development, Brendzainjected another dye, developed by scientists at the University ofPittsburgh, that temporarily sticks to amyloid. He showed that as theplaques appeared, nearby bran...Mouse brain cells rapidly recover after Alzheimer's plaques are cleared
...oducea dye that allowed Brendza to obtain detailed images of nerve cellbranches.To correlate brain cell changes with plaque development, Brendzainjected another dye, developed by scientists at the University ofPittsburgh, that temporarily sticks to amyloid. He showed that as theplaques appeared, nearby bran...Elusive HIV shape change revealed; Key clue to how virus infects cells
...tained the first high-resolution three-dimensional images of the protein in its unbound form. They surmounted considerable technical challenges, including difficulty in getting gp120 to form good crystals. "Without very well-ordered crystals you get a very blurry picture," explains Harrison. "It took a ver...New, automated tool successfully classifies and relates proteins in unprecedented way
... fluorescently tagged proteins fromhigh-resolution images of cells. This technical feat opens a new way toid... inside cellimages, we also can study thousands of images fast, objectively andwithout error," Murphy said.Murphy's tool has two key components. One is a set ...