Detecting cold, feeling pain: Study reveals why menthol feels fresh
...cts temperature sensation. But in so doing it also illuminates a mechanism that mediates how the body experiences intense stimuli – temperature, in this case – that can cause pain. As such, the receptor – known as menthol receptor TRPM8 -- provides a target for studying acute and chronic pain, as can result ...Why doesn't the immune system attack the small intestine?
... to leave healthy tissue alone. The finding, which illuminates a previously unknown corner of the human immune system, may lead to new forms of treatment for autoimmune diseases such as Type 1 diabetes and multiple sclerosis. "We've discovered that cells not generally thought of as part of the immune system ac...Newly discovered behavior in cancer cells signals dangerous metastasis
...tructed a fluorescent "reporter" -- a protein that illuminates if the cell turns epithelial but lies dormant if the cell reverts to mesenchymal state. By following the reporter's illumination within cancer cells in rats, the team viewed the very process of alternative splicing as it occurred in the tumors. The ......construct the ancient gene they split off from. It illuminates the mechanisms and processes that evolution uses, and tells us more about how Mother Nature engineers life." The ability to reconstruct an ancient gene from descendant genes also raises the possibility of a new type of gene therapy, in which a por...Scientists elucidate the kinome of key model organism
...n which to study conserved cellular processes, and illuminates a period in the evolutionary history of the metazoa after the divergence of the plants but before that of the fungi. "Our findings document the impressive evolutionary creativity of the Dictyostelium kinome- a large portion of the kinases are unique...Morning grogginess more debilitating than sleep deprivation, according to CU-Boulder study
...-call, sleep-deprived individuals. The study also illuminates the challenges faced by everyday people who are forced to make crucial decisions following abrupt awakening. "If a person is awakened suddenly by a fire alarm, for example, motivation alone may be insufficient to overcome the effects of sleep inerti...Defective immune system response to smallpox vaccine detailed in new study
...Atopic Dermatitis and Vaccinia Network scientists, illuminates one potential mechanism leading to eczema vaccinatum and improves our understanding of the immune responses to smallpox vaccine of people with atopic dermatitis," says NIAID Director Anthony S. Fauci, M.D. Published in this month's issue of Immunity...