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Tag: "identifying" at biology news

Genomic Analysis Uncovers New Targets for HIV Vaccine

..., which plays a major role in the immune system by identifying foreign invaders and "tagging" them for destruction. Two of the HLA genes, known as HLA-A and B, are turned off by HIV when it enters the body, which keeps the immune system from recognizing the virus as foreign. HLA-C however is not thought to be t...

Researchers discover inherited mutation for leukemia

...k for both genetic and epigenetic alterations when identifying problem genes," he says. CLL is the most common form of adult leukemia, with 15,300 new cases and 4,500 deaths from the disease expected this year in the United States. The leukemia is slightly more common in men than women, and typically strikes...

The insect vector always bites twice

...d this still little known response with the aim of identifying in the arthropod vector saliva the immunogenic proteins responsible. They called on immunological techniques to evaluate qualitatively and quantitatively, in the serum sampled from human populations living in transmission areas, the presence of antib...

Genetic factors are linked to fever following smallpox vaccination

...t implications when it comes to the future goal of identifying individuals at risk for fever before they are given a specific vaccination. Crowe writes, “The long-term goal is to determine genetic features that could be determined prior to vaccination, allowing practitioners to modulate the vaccination plan acc...

New findings challenge established views on human genome

... devised and tested high-throughput approaches for identifying functional elements in the genome. Those elements included genes that code for proteins; genes that do not code for proteins; regulatory elements that control the transcription of genes; and elements that maintain the structure of chromosomes and med...

Exploring the dark matter of the genome

...rosophila will provide an essential foundation for identifying the proteins and components involved in epigenetic inheritance, as well as other mysteries surrounding the genome's "dark matter." "Sequence finishing and mapping of Drosophila melanogaster heterochromatin," by Roger A. Hoskins, Joseph W. Carls...

Human genetic 'deserts' are teeming with significant life

... US National Institutes of Health, with the aim of identifying all functional elements in the human genome sequence. The pilot phase is focusing on 44 regions, totalling approximately 1% of the human genome. By testing and comparing existing methods for annotating the human genome the consortium members hope to...

Surprising origin of cell's internal highways

...' for this delivery," she said. In addition to identifying this novel site of microtubule nucleation, Kaverina and colleagues also examined the molecular mechanisms governing the process. They found that proteins normally associated with the plus ends of microtubules, called CLASPs, localize to a specific co...

Antarctic icebergs -- Hotspots of ocean life

...water caves and to the undersides of the icebergs, identifying and counting animals with its color video camera, collecting samples, and surveying its topography.” Based on their new understanding of the impacts of the icebergs and their growing numbers -- the researchers counted close to 1,000 in satellite i...

Understanding why C. difficile causes disease -- it's hungry

...that might shut down the gene that codes for R. By identifying such a protein, Sonenshein hope to find a way to change the appetite of the bacteria. "If we find a way to shut down toxin production in the hypervirulent strain, we might have a new way to treat the disease," says Sonenshein....

Gene mutation linked to cognition is found only in humans

... nonhuman primates, recent studies have focused on identifying genes that have been positively selected during human evolution. They conclude, "The present results underscore the potential importance of the creation of novel splicing forms in the central nervous system in the emergence of human cognition."...

Fat screen delivers plant-derived chemical with antidiabetic effects

...n for fat cell screens as a promising strategy for identifying new metabolic drugs, according to the researchers. While harmine itself has effects on the central nervous system that may preclude its use, "it may eventually be possible to separate the nervous system and metabolic effects of harmine through opt...

LIAI scientists make important finding on cytomegalovirus transmission

...said, "The main importance of these experiments is identifying the critical molecular targets controlling virus persistence, and two ways in which we can modulate immunity in vivo with the desired result of blocking virus spread to uninfected individuals. "The potential excitement in the findings is that we m...

DOE JGI sets 'gold standard' for metagenomic data analysis

...metagenomes is binning. Binning is the process of identifying from what organism a particular sequence has originated. There are several methods employed to bin sequences. BLAST (Basic Local Alignment Search Tool) is a method used to rapidly search for similar sequences in existing public databases. Mavro...

Effect on breast tumors of DNA alternations in 3 genes described

...omoter hypermethylation is potentially reversible, identifying cancers with different hypermethylation may have important consequences for breast-cancer treatment."...

A new portable biosensor detects traces of contaminants in food more quickly and cheaply

...pesticides) and for sulphanilamide (in the case of identifying antibiotics). Once the antibodies hook onto the contaminating particles they are attracted to the surface of a transductor which converts the contact with the antibodies into electrical signals. By measuring these electric signals the device can dete...

Brain maps online

...on of normal brains, and could help researchers in identifying fine morphological and chemical abnormalities underlying Alzheimer's, Parkinson's and other neurological diseases, Mikula said. To make the maps, the researchers started with sections of brain mounted on microscope slides. Those slides were scann...

Deconstructing brain wiring, one neuron at a time

...ieve to be a major hurdle to preparing that chart: identifying all of the connections to a single neuron. In the...se apart the chain of directly connecting neurons, identifying them one by one. Viruses that naturally spread between neurons have previously been used to outli...

NIDA study identifies genes that might help some people abstain from smoking

...ctor Dr. Nora D. Volkow. “It marks a movement from identifying the genetics of addiction vulnerability to identifying the genetic basis of successful abstinence. This knowledge could impact the success rate of cessatio...

NIAID expands capability for influenza research and surveillance

... viruses evolve, adapt and transmit infection; and identifying immunological factors that can determine whether a...g regimens and factors that drive drug resistance; identifying viral markers that may indicate how a virus becomes deadly, adapts and transmits infection; uncoveri...

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