Master genetic switch found for chronic pain
...nociceptive information processing. "Finally, the identification of a core transcriptional control program for many of the ion channels and receptors known to transduce noxious stimuli has intriguing implications for the design of more effective pain therapies," they wrote. ...'Virus chip' detects new virus in prostate tumors
...sease, the researchers say. While most other virus identification techniques require researchers to look for only a ...chnology. As with most scientific discoveries, the identification of this virus in human prostate tissue prompts many more questions than it answers, they emphasize. ...Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders
... misfolded proteins and their aggregation, but the identification of KCNC3 mutations and their functional characterization represent a novel avenue for understanding cell death," said Stefan M. Pulst, M.D., director of the Division of Neurology at Cedars-Sinai Medical Center, holder of the Carmen and Louis Warschaw...... at The Institute for Genomic Research, report the identification of more than 10,000 SINE insertions in the canine genome and describe the potential impact of these insertions on phenotypic diversity in dogs. "These SINEs are bimorphic, which means that at a given locus, some dogs have the SINE sequence while oth...Scientists fetch useful information from dog genome publications
... at The Institute for Genomic Research, report the identification of more than 10,000 SINE insertions in the canine genome and describe the potential impact of these insertions on phenotypic diversity in dogs. "These SINEs are bimorphic, which means that at a given locus, some dogs have the SINE sequence while oth...Researchers develop new method to help find deadly malaria parasite's Achilles heel
...sms is an intriguing result that could lead to the identification of novel drug targets for fighting malaria," said John Whitmarsh, acting director of the Center for Bioinformatics and Computational Biology at the National Institute of General Medical Sciences, which partially funded the work. "Ideker and his team ...New study of the world's smallest elephant
...e information that is currently lacking, including identification of priority areas for the species that should be kept under forest cover. "The project will also include training for Malaysian MSc student, Ms Nurzhafarina Othman in population biology and conservation genetics; and training for governmental and ...Gene expression profile helps predict chemotherapy response in ovarian cancer patients
...al disease status," notes Cannistra. "And with the identification of each new gene expression profile, we come one step closer to eventually being able to develop treatments tailored to individual ovarian cancer patients." Coauthors of the study include BIDMC investigators Dimitrios Spentzos, MD, Douglas Levine, M...New U. of Colorado at Boulder flu chip may help combat future epidemics, pandemics
...strain analysis of influenza, said Rowlen. Strain identification is critical for tracking emerging strains and in d...id the team hopes to cut down on the 11-hour virus identification process. "We are now looking at ways to amplify the fluorescent signal after we capture the RNA on ......taphylococcus aureus from otitis media. For the identification of the genes involved in the formation of the biof...d lost the capacity to form biofilm, thus enabling identification of the essential genes and positive regulators of the process. The results showed that a positive re...Novel enzyme offers new look at gene regulation
...om histones inside a test tube. The result was the identification of a novel protein, JHDM1A, named for JmjC histone demethylase 1A. A similar protein exists in baker's yeast and has the potential to remove trimethyl groups. JmjC is only a section of the entire JHDM1A protein, but is required for its demethylase a...Neurons generated in the adult brain learn to respond to novel stimuli
...labeled to mark those that were dividing, allowing identification of newly generated, adult-born neurons. These mice were then exposed either to a panel of unusual odors or to a normal environment. Several weeks later, the response of the adult-born neurons was evaluated by measuring the activity of genes known to...Role of microRNA identified in thyroid cancer
...ing to understand how important they may be. "The identification of miRNA 'signatures' in cancer and other diseases has really changed the way we think about the process of malignant growth," says He. Old dogma held that a gene carries a recipe for a molecule of messenger RNA which, in turn, carries a blueprint...New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus
...ould be useful for antiviral development. With the identification of the polymerase genes contributing to disease, that represents another set of genes that might also be a good target for prophylactic and therapeutic interventions," Tumpey said. Although more research needs to be done on antivirals and vaccines f...Deep treasure to be found in Oculina Bank
...e assessment of the extent of the reefs and likely identification of previously unknown coral features. "Understanding the extent of the reefs and where the most important habitats are will help researchers and managers determine those areas that need the greatest protection, and those that might require less p...New neurons take baby steps in the adult brain
... make them glow with a green protein to ease their identification in the adult brain. Ge measured the electrical output of the neurons to establish whether they had become connected to other neurons. "Getting new neurons to form connections in other parts of the brain may be helped through the same steps that nat...CO2 sensing proves critical for fungal pathogens to adapt to life in air and human hosts
...h and differentiation in the fungal kingdom. The identification of a link between CO2 sensing and fungal virulence may have broad implications for the study of microbial pathogens and the role of adenylyl cyclase in virulence trait regulation by CO2. Furthermore, it may in time facilitate the development of a new...Retinal scans eyed for New Mexico show cattle
... a combination of eye-scanning and radio frequency identification (RFID) ear tags for animal ID evaluation. Most of ... Encinias said. When the idea of mandatory cattle identification was introduced several years ago, cattle producers were concerned about expense, inconvenience and l...UF study first to quantify validity of DNA I.D. tool using marine snails
... first test quantifying the effectiveness of a DNA identification tool among brightly colored shells. With an error ...tion with its promise as a valuable aid in species identification and discovery," said Christopher Meyer, a UF biologist and one of the researchers. "However, few com......ndistinguishable" polymorphisms can complicate the identification of disease-related genes. "Although they should pose few difficulties when they are located close together on the same chromosome, they often occur on different chromosomes, where it is quite another story," explains Cardon. When this is the case, ...