Scientists unravel clue in cortisol production
...roduction, finding that although the output of the hormone is continuous, the molecular production is cyclic ...ocrinology. Turning cholesterol into the stress hormone cortisol involves many reactions and begins when the hypothalamus sends a signal to the adrenal glan...FDA causes unnecessary scare about common painkillers
...known as selective COX-2 inhibitors because of the hormone they target. The other NSAIDs are known as "non-selective." Furberg said while the evidence for the non-selective NSAIDs is somewhat limited, an analysis combining several small studies found that high doses (500 mg twice daily) of Aleve were not ...Bacteria research offers hope for new vaccine against meningococci
...e bacteria aggregate in the thyroid and can impact hormone production during the infection,?says Ann-Beth Jonsson. The study also shows that bacteria that lack a certain adhesin (the protein that the bacteria cells use to adhere to the receptors) could not attach to mucous linings. Thanks to the new sy...Pregnancy hormone key to repairing nerve cell damage
...esearchers who have shown that a pregnancy-related hormone is responsible for rebuilding the protective coati...orts that a study conducted on mice found that the hormone prolactin encourages the spontaneous production of myelin, the fatty substance that coats nerve cell...... Shizgal's team investigated the role of leptin, a hormone that the body produces in proportion to the amount of stored fat. A person who eats a lot during holidays, for example, will make more leptin than a person who sticks to a stricter diet. In work carried out by Shizgal's team, chubby lab rats were...Molecular signature may identify cisplatin-sensitive breast tumors
...mors. About 20 to 30 percent of tumors, some with hormone receptors, have elevated levels of a growth-promoting protein called HER2, and those tumors are candidates for treatment with the monoclonal antibody Herceptin. The third major subtype is the 15 to 20 percent of breast tumors that have neither estro...Gene expression test reveals ER and HER-2 status of breast tumors
...s whether a tumor's growth is fueled by the female hormone estrogen and the role of a growth factor receptor ...us, and also gauge the sensitivity of the tumor to hormone therapy and chemotherapy," says Lajos Pusztai, M.D., Ph.D., associate professor in the M. D. Anderso...Notorious cancer gene may work by destroying messenger
...wth factors, which activate genes in response to a hormone or other signal. PMR1 also plays a key role in Cooley's anemia, which causes the loss of red blood cells in infants and children. For the present study, Schoenberg and coauthor Yong Peng, a research associate in Schoenberg's laboratory, wante...Growth hormone is not the anti-aging bullet for healthy adults
A review of published data on use of human growth hormone (GH) by healthy elderly people found that the synthetic hormone was associated with small changes in body composition but not in body weight or other clinically imp...Natural gut hormone offers hope for new obesity drug
A hormone found naturally in the gut is the basis of a new d...n PP-secreting tumours have elevated levels of the hormone and yet appear to show no adverse side-effects. "These people may have had high levels of PP for t...Scripps research team discovers a chemical pathway that causes mice to overeat and gain weight
...wn to stimulate the release of leptin-an important hormone secreted by white fat cells and a suppressor of appetite. However, in this model, lack of EP3 did not prevent leptin increase. "Something is happening there in that circuit," says Sanchez-Alavez. "The PGE2 and leptin may be interacting and controllin...Scientists find hormone activity explains adolescent mood swings
...dical Center, report findings demonstrating that a hormone normally released in response to stress, THP, actu...ect at puberty, when it increases anxiety. This hormone normally acts like a tranquilizer, acting at sites in the brain that "calm" brain activity. In the a...Gene variations contribute to aggression and anger in women
..., Hungary. Previous studies have associated the hormone serotonin with anger and aggression in both humans and animals and have shown that increased serotonin activity is related to a decrease in angry and aggressive behaviors. In the study being presented today, researchers sought to determine if this re...Stress may help cancer cells resist treatment, research shows
...f Medicine are the first to report that the stress hormone epinephrine causes changes in prostate and breast cancer cells that may make them resistant to cell death. "These data imply that emotional stress may contribute to the development of cancer and may also reduce the effectiveness of cancer treatments...How appetite-stimulating brain cells work overtime during fasting
...researchers revealed a link between active thyroid hormone in the brain and increases in an "uncoupling" prot...now that that portion of the brain harbors thyroid hormone receptors and has the capacity for local production of T3. Now, the researchers found that suppor...'Guardian of the genome' protein found to underlie skin tanning
...n cells called keratinocytes to make and secrete a hormone called alpha-MSH, which attaches to nearby skin cells called melanocytes and spurs them to produce skin-darkening pigment called melanin. The chain of events within keratinocytes that leads to alpha-MSH production, however, was a mystery. Investig...Researchers learn what sparks plant growth
...factors that regulate production and uptake of the hormone in the different layers of plant tissues. According to Chory, brassinolide is a potent growth hormone involved in the plant’s response to light. Such responses, which include adjusting plant growth to r...Researchers identify gene involved in dog size
...ation in one gene—IGF-1, which codes for a protein hormone called insulin-like growth factor 1, is very strongly associated with small stature across all dog breeds studied. “We have been intrigued by the population structure of dogs, which over the years have been selectively bred, allowing us to more r...Researchers design pulsed mircrojet system to deliver protein drugs without pain or bruising
...s and protein therapeutics such as insulin, growth hormone and erythropoietin, a red blood cell booster. Needle-free delivery of vaccines has recently been identified as one of the significant emerging challenges in global health. The researchers felt that the pain and bruising caused by previously-devel......responsible for the loss of sensitivity to the fat hormone known as leptin. Therapeutic strategies designed t... lacked normal leptin levels, simply restoring the hormone might have been a means for weight loss. It soon became clear that there was a problem: obesity i...