Buildup of damaged DNA in cells drives aging
...ing those controlled by growth hormone. How growth hormone pathways are suppressed is not known, but this res...y, in particular by genes that regulate the growth hormone and insulin pathways," said Laura Niedernhofer, M.D., Ph.D., assistant professor of molecular geneti...Spike in testicular cancer is focus
...ure to environmental factors such as environmental hormone disruptors increases the risk of testicular cancer. They will measure the levels of these environmental compounds in 800 patients with testicular cancer and in an equal number of unaffected control subjects. Because so little is known about the pot...Changing length of days reverses how estrogen affects aggressiveness in mice
...against the common belief that testosterone is the hormone that regulates aggression," said Randy Nelson, co-...mpared to short days could not be explained by the hormone using different receptors in different times of year," Trainor said. So how did estrogen have opp...Research suggests beta agonists may alter the immune system
...ts belong to a class of chemicals that include the hormone adrenaline produced by the body. Consequently, conditions that elevate blood adrenaline, such as emotional stress or heart failure, may also have the ability to alter the immune system by increasing type 2 T cells, and thereby promote or worsen disea...Hormone linked to brain's cravings for food and other energy sources
Ghrelin, a hormone produced in the stomach, induces food intake and o...on. Ghrelin was previously associated with growth hormone release, appetite, learning, and memory and has now been linked with the reward circuitry of the bra...Plant-derived molecules, genetic manipulation point to future chemoprevention methods
...ic alteration that reduced amounts of a key growth hormone had fewer carcinogen-induced tumors than mice with...search suggests that reducing levels of the growth hormone IGF-1 could prove to be a promising method for preventing colon cancer from developing. It is also t...Some butterflies travel farther, reproduce faster
... more total protein vitellogenin juvenile hormone Juvenile hormone appears to be a key. It plays an important role in regulating egg and larval development and also re...From managing sugar to managing healing
Insulin is a hormone known primarily for regulating sugar levels in the blood, yet researchers at the University of California, Riverside, recently found that applying insulin directly to skin wounds significantly enhanced the healing process. Skin wounds in rats treate...Longer-lived rodents have lower levels of thyroid hormone
...ts showing significantly lower levels of a thyroid hormone that speeds metabolism, a new study has found. Th...Pinto will present the study "Differential thyroid hormone activity in rodents with different life spans" at a poster session Oct. 9 at Comparative Physiology ...Studies look at how genes affect antipsychotic drug response
...ar disorder. An increase in prolactin (a pituitary hormone that may affect bone development) or weight gain occurs in some but not all of these young patients. "We are trying to determine if some kids are at a greater risk than others for these problems by analyzing genetic markers," Bishop said. Bishop ...Eating protein boosts hormone that staves off hunger
The amount of a hunger-fighting hormone can be increased by eating a higher protein diet, researchers report in the September issue of the journal Cell Metabolism, published by Cell Press. The hormone, known as peptide YY (PYY), was earlier found by the researchers to reduce food intake by...Hair-growth drug artificially lowers PSA levels in prostate cancer screening, study finds
...nd male-pattern hair loss have to do with the male hormone testosterone, which is being converted to dihydrotestosterone (DHT) by an enzyme named 5-alpha reductase. DHT activates the genes responsible for the development of male-pattern hair loss. Finasteride interferes with this process by blocking 5-alpha ...New brain-chemistry differences found in depressed women
...ssion. Others include the corticotrophin-releasing hormone system, and those involved in noradrenaline, dopamine and serotonin production. "Further research on these differences, and their relationship to patients' responses to various depression treatments, is crucial to the continued improvement in the...Male contraception: One door opens, another closes
...ecting the compound as an attachment to a modified hormone that seeks out the testes, researchers have found that a low dose is both safe and effective in rats. Without this targeting mechanism, only much higher doses are effective--but they are harmful to the body's organs. Dr. Diana Blithe of the U.S. ...Molecular atlas provides new tool for understanding estrogen-fueled breast cancer
... and overcome the problem of resistance to current hormone therapies, the study authors say. The estrogen receptor (ER) is an intricate protein net in the nucleus of breast cancer cells. When the receptor snares an estrogen molecule, it sets in motion a cascade of activity among genes involved in cell grow...Stress hormones may play new role in speeding up cancer growth
...metastasis. The research also suggests the same hormone can also stimulate the tumor cells to release anot... and VEGF. This showed that the receptors for this hormone were present on cells in Glaser's cell line, but that might have been just a laboratory aberration i...Major link in brain-obesity puzzle found
...in cells. Using a variety of genetic, diet and hormone techniques, they were able to show that the action of SH2B1 regulates body weight, the action of the metabolic signaling molecules leptin and insulin, and the use of energy from food. It even moderated the impact of a high-fat diet on body weight. ...Growth hormone to boost athletic performance risks diabetes
Use of growth hormone to boost athletic performance can lead to diabetes...abolic steroids for 15 years and artificial growth hormone for the past three. He had also taken insulin, a year after starting on the growth hormone. This...The influence of the menstrual cycle on the female brain
...ors, progesterone or androgens. 7. Luteinizing hormone (LH) is a hormone produced by the pituitary gland. Its main role is to trigger ovulation, which occurs between 36 and ...... recommended five years of tamoxifen treatment for hormone responsive tumors. Among women over 65 and treated...r their initial treatment. Augmenting surgery with hormone modulating drugs, such as tamoxifen, further improves survival and reduces recurrence. Women ove...