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Tag: "hints" at biology news

Newly-discovered class of genes determines ?and restricts ?stem cell fate

Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes ?dubbed pangenes ?can both govern a stem cell's fate and put a hold on future differentiation until the time is right. ...

Study finds more than one-third of human genome regulated by RNA

...edicts Lewis.In addition, the team discovered some hints about how microRNAs findtheir targets.To produce a protein, the cell first makes a template for that proteinby constructing a molecule called messenger RNA. MicroRNAs inhibitprotein production by associating themselves with particular messengerRNAs, ...

NYU researchers simulate molecular biological clock

...edicts Lewis.In addition, the team discovered some hints about how microRNAs findtheir targets.To produce a protein, the cell first makes a template for that proteinby constructing a molecule called messenger RNA. MicroRNAs inhibitprotein production by associating themselves with particular messengerRNAs, ...

50-year-old Mystery Solved: Protein Tags Regulate Key Ion Channel

...rols one important process at the cell surface and hints that it may influence others." Additional authors include co-first authors Sindhu Rajan and Leigh Plant, as well as Michael Rabin and Margaret Butler, all from the Institute for Molecular Pediatric Sciences at the University of Chicago. "I am proud ...

Stem cells from brain transformed to produce insulin at Stanford

...s a first step towards that eventual goal. It also hints that neuronal stem cells have many potential uses beyond treating brain disease. He thinks this work has additional value because the method used to produce insulin from neural stem cells is completely new. "The more ways we discover to form insulin...

Researchers uncover sequence of major rice pathogen

...plains, scientists use comparative genomics to get hints about where to concentrate their study efforts. "M. grisea contains about 11,000 genes, so you can't look at every one," he says. "The comparative study allows us to look at novel classes of genes and novel proteins and prioritize study efforts." "...

A little stress gives beneficial oomph! to immune system

...ocytes are mobilized in great numbers at the first hints of acute stress, the immune proteins that are generated at the battle site will determine which types of immune cells are further recruited in greater numbers," Dhabhar said. "Different types of immune challenges may produce different cocktails of im...

High fidelity keeps human DNA assembly line humming

... how RNA and NTP bases hook up. Preloading of NTPs hints at a previously unknown quality control station to maintain accuracy of RNA synthesis. If an NTP doesn't match up properly with DNA, the system stalls ?and even backs up to correct the error. "We're able to show how an error will be sensed and corre...

Pinpointing the cause of a neurodegenerative disorder

...aid Zoghbi. She noted that earlier studies yielded hints that the glutamine repeats somehow caused Ataxin-1 function to be altered in a way that damaged or killed Purkinje cells. "We had been accumulating clues that the glutamine tract expansion is clearly what is important for disease because that's the ...

Unweaving amyloid fibers to solve prion puzzles

...h this work was done in yeast, the results provide hints as to why mad-cow type diseases tend to have a difficult time jumping species. "These findings give us some fundamental insights in how amyloid fibers form," says Whitehead Member Susan Lindquist, lead scientist in the research team whose results wi...

Discovering the first steps in transcription-coupled repair

...by what means was unknown. In addition, there were hints for an important but unknown role for the protein XPG in transcription-coupled repair. In both humans and mice, when gene mutations produce a severely truncated form of XPG, the result is profound Cockayne Syndrome and very early death. Through an i...

'Executive' monkeys influenced by other executives, not subordinates

...trol their reaction." However, he said, there were hints that gaze-following didn't have all the features o...reflexive action, but these were only hints. Such hints -- as well as previous studies in the Platt laboratory -- led Shepherd and Platt to explore whether ...

Blood flow in brain takes a twist, affecting views of Alzheimer's

... looked at slices of brain tissue and come up with hints that astrocytes might regulate blood flow in brain tissue. The current research, funded by the National Institute of Neurological Disorders and Stroke, relies on a sophisticated laser system developed by Nedergaard to study the activity of astrocytes...

Genetic snooze button governs timing of spring flowers

...ex interplay of genes and environment and provides hints that, one day, it may be possible to exert precise control over flowering, a process essential for plant reproduction and fruiting and that has enormous implications for agriculture. Flowers are the reproductive organs of plants and are responsible...

Ghost protein leaves fresh tracks in the cell

...nd to ankyrin to do its job," said Dubreuil. "This hints at a complexity we never had any idea about in trying to understand how these molecules work." Dubreuil and his colleagues initially assumed that ankyrin was the key to targeting spectrin in all cells. But research in many laboratories had failed t...

Brains can recover from alcoholic damage but patients should stop drinking as soon as possible

...ker of neuronal integrity), while choline provides hints at how cell membranes are being broken down and repaired. In addition, the neuropsychological performance of the patients was tested at the beginning and end of the study, using a specific test (the d2-test) that primarily measures attention and c...

Lost in the labyrinth

...cked at early stages, but in a different way. This hints that they may be controlled by other protein links in the Wingless pathway as well. Perhaps most strikingly, beta-catenin appears to make cells take decisions about their fate before they leave the stem cell compartment in the bone marrow, something ...

One-of-a-kind imaging probe reveals secrets useful for drug discovery

...onsidered. It's the kind of thing that may provide hints about drug discovery in future." More than 40 years ago, Jerrold Meinwald, Ph.D., an emeritus professor of chemistry and chemical biology at Cornell University, led landmark chemical studies of walking stick venom. He was pleased to know the insect ...

Dig deeper to find Martian life

...mp; Experimental Biology (CoMPLEX), said: "Finding hints that life once existed ?proteins, DNA fragments or fossils ?would be a major discovery in itself, but the Holy Grail for astrobiologists is finding a living cell that we can warm up, feed nutrients and reawaken for studying. "It just isn’t plausi...

RNAi shows promise in gene therapy, Stanford researcher says

... In early RNAi experiments, researchers saw some hints that the technique could induce an immune reaction or switch off the wrong gene or genes. In work last year, Kay confirmed those findings but also showed a possible way around those toxic effects by selecting particular RNA sequences. "One ben...

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