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A gene's first 'kiss' sets off that affair known as puberty

...etion, was no longer dormant, with levels 25-times higher than its baseline of zero. In addition to Dr. Plant, other authors of the PNAS paper are Muhammad Shahab, Ph.D., formerly a fellow working with Dr. Plant and now with the department of biological sciences at Quaidi-i-Azam University in Islamabad, Pa...

Wisconsin scientists grow critical nerve cells

...ping changes may well be the developmental norm in higher vertebrates such as humans. "We cannot simply translate studies from animal to humans," says Zhang. The next step, Li says, will be to test if the newly generated neurons can communicate with other cells when transplanted into a living animal. The ...

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...nd palm and coconut oils; they are associated with higher risk of coronary disease. The healthier polyunsaturated fats are those that remain liquid at room temperature, such as various types of vegetable oils. Trans-unsaturated fatty acids, or trans fats, are artificially produced solid fats used in shorte...

Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer

...apacity, the risk of breast cancer was three times higher among women with the poorest DNA repair capacity compared with those with the highest. "[T]hese data support the hypothesis that deficient DNA repair capacity is associated with susceptibility to breast cancer and may be a valuable in vitro biomarke...

Lack of enzyme turns fat cells into fat burners

... a normal diet, fatty acidoxidation was 80 percent higher in the fat cells of the mice lackingACC2 when comp...ve months, the ACC2-deficient mice hada 25 percent higher rate of fatty acid oxidation and twofold higherrate of glucose oxidation than the normal mice.Others...

Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas

...efined as under five and one-half pounds -- have a higher risk for developing type 2 diabetes. To understan...scence), the low-birth-weight babies began showing higher levels of blood glucose. "By 6 months, these levels had spiked abnormally, to 500 mg/dl -- the equiv...

Anti-bacterial additive widespread in U.S. waterways

...r-billion). This maximum concentration was 28 fold higher thanpreviously reported levels, which are currently used by the U.S.Environmental Protection Agency for evaluation of the ecological andhuman health risks of triclocarban."Along with its chemical cousin triclosan, the antimicrobial compoundtriclocarb...

Tiny particles could solve billion-dollar problem

.... As metal particles get progressively smaller, a higher percentage of the atoms in the particle are found on the surface of the particle instead of being locked away inside the metal where they cannot interact with other chemicals. For example, in the bulk palladium, less than 4 percent of the palladium a...

Male circumcision reduces risk of HIV transmission from women to men

...exualpartners, which was found to be significantly higher than infectivityrates calculated in the past from studies of monogamous couples. Theirresults may help explain the rapid spread of HIV in settings wherecircumcision is not common and multiple sexual partnerships are. Between1993 and 1997, 745 male e...

The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life

...f the inner workings of living organisms at a much higher level of detail than ever before. One innovation of SPIM is the illumination of a sample from the side rather than along the traditional view of the microscope lens. This eliminates a problem that has plagued three-dimensional microscopy in the past...

Researchers reveal the infectious impact of salmon farms on wild salmon

...died was four orders of magnitude - 30,000 times - higher than natural. These lice then spread out around th...rm. Infection of wild juvenile salmon was 73 times higher than ambient levels near the farm and exceeded ambient levels for 30 kilometers of the wild migratio...

Jefferson Virologists Coax HIV Out of Hiding

... years.?They found that the virus wasstimulated to higher levels and was activated in more patients thanwith other compounds. Dr. Pomerantz’s group also discovered that IL-7appears to stimulate a group of sub-strains of HIV that are differentthan those brought out of latency by other agents, such as IL-2,an...

Clam embryo study shows pollutant mixture adversely affects nerve cell development

... an ATSDR* study inthe year 2000 that documented a higher than usual rate of autismspectrum disorder and explored its link to bromoform, chloroform, andtetrachloroethylene in Brick's water supply--it got her thinking. "Myhypothesis was this: While it had been proven that individually thechemicals don't impa...

Study identifies predictors of HIV drug resistance in patients beginning triple therapy

... an ATSDR* study inthe year 2000 that documented a higher than usual rate of autismspectrum disorder and explored its link to bromoform, chloroform, andtetrachloroethylene in Brick's water supply--it got her thinking. "Myhypothesis was this: While it had been proven that individually thechemicals don't impa...

Gene variations explain drug dose required to control seizures

...e more likely to be found in patients who required higher dosages of anti-epileptic drugs. The findings sug...ics is great," Goldstein said. "For someone at the higher end, it can take months to get their seizures under control. This study uncovers factors that might ...

Researchers discover molecule that causes secondary stroke

...ave elevated levels of bilirubin and significantly higher levels of BOXes. One of the 12 who had elevated bilirubin, but hardly any BOXes, did not experience a secondary stroke. When bilirubin is elevated, says team member Gail Pyne-Geithman, PhD, it must be exposed to powerful oxidizers that cause the pr...

Introduced foxes transformed vegetation on Aleutian Islands from lush grasslands to tundra

... to walk around because the plants don't grow much higher than your ankles. But on the other islands, it's h...ds on fox-free islands was two orders of magnitude higher than on fox-infested islands. The resulting difference in nutrient inputs was reflected in soil phos...

Gene Therapy For Parkinson's Disease Moves Forward In Animals

... but it's encouraging to see data that it works in higher animals like monkeys.?/p> Meanwhile, in separate experiments with rats, researchers used gene therapy to completely reverse abnormal movements called dyskinesias in some of the animals, suggesting a new way to combat the flailing movements produc...

New studies suggest airborne SARS transmission is possible

...ts in hospital bays near a SARS patient had a much higher infection rate than patients in distant bays, consistent with the possibility of airborne SARS transmission, according to an article in Clinical Infectious Diseases. Both articles are published in the journals' May 1 issues, and are now available onl...

Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed

... means it couldn't have contributed as much to the higher sea level. In an area called Siple Dome, the ice sheet currently rises 1,000 meters -- more than half a mile -- above a bedrock plateau. Some computer reconstructions indicate it was perhaps twice as thick at the end of the last ice age, also called...

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