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Tag: "hepatocytes" at biology news

Soft-cell approach cuts animal tests

...oxic effect on the liver, liver type cells such as hepatocytes can be chosen. The in vitro technique is cheap and portable, so scientists can measure immediate toxicity events, rather than waiting for toxicity to be expressed as organ or organism failure many months or even years down the track from initial ...

New culture method for hepatitis C virus uses primary hepatocytes and patient serum

... host's natural defenses. Interestingly, cultured hepatocytes responded to viral replication by displaying signs of distress and cell death and by expressing interferon-beta, a cellular antiviral, in an effort to control the infection. This culture system provides a breakthrough in studying HCV replication ...

Interaction between lymph and liver cells may affect immune response

...s), liver sinusoidal endothelial cells (LSECs) and hepatocytes (liver cells) using electron microscopy. LSECs are...n order to cross the endothelial barrier, and that hepatocytes can function as APCs. In fact, this T cell activation in the liver during early hepatitis C infectio...

Cycles of cell death, proliferation key to liver cancer

...es was the finding that while NF-ƒÛB activation in hepatocytes (liver cells) prevents liver cancer, its activatio...tudied what precedes inflammation ¡V the injury of hepatocytes caused by toxic chemicals, which sets in motion the inflammation process. Their research showed th...

Evolutionary conservation of a mechanism of longevity from worms to mammals

...where analyzed, the authors found that a subset of hepatocytes exhibited loss of heterozygosity (effectively becoming mclk1-/- cells) and had undergone clonal expansion. The authors suggest that these mclk null cells were able to out-compete mclk1+/- hepatocytes, suggesting that resistance to oxidative stress u...

Gene therapy advance treats hemophilia in mouse models

...lls to make more of it. In effect, we're using the hepatocytes as a factory to make this protein and secrete it into the bloodstream." To better target the hepatocytes in the mice, the team took the disabled protein coat from the baculovirus Autographa californica and...

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