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Tag: "heme" at biology news

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

...eds no refrigeration. The drug works by preventing heme crystallization, which destroys the parasite by bu...ood cells as efficiently, and if the efficiency of heme binding is pushed in the wrong direction, they can't prevent heme from crystallizing. "We know these...

Antioxidant protects against lung damage in silicosis

Levels of heme oxygenase-1 (HO-1), an antioxidant that protects against reactive oxygen species (damaging oxygen molecules that cause direct tissue injury), become elevated in the lungs of chronic silicosis patients and could represent a new treatment approach for ...

ABCB6 is key to production of heme in hemoglobin

...namic relationship between ABCB6 and the levels of heme and porphyrin that helps to regulate the productio...serious problems in the cell by altering levels of heme or porphyrins," Schuetz said. Armed with this new information, researchers will be better able to s...

Vaccine shown effective against chancroid

... from binding hemoglobin and, hence, obtaining the heme it needs to survive, the authors said. In skin biopsies of the immunized animals, the researchers found no viable chancroid bacteria. An HIV vaccine has been elusive in part because the virus constantly varies its surface molecules, making it an e...

Free-radical busting antioxidants might not promote healthy hearts

...ended on the induction of a cellular enzyme called heme oxygenase-1 (HO-1). HO-1 is known to protect against atherosclerosis in animal models, although the mechanism is not completely clear. Not surprisingly, HO-1 was not induced by Vitamin E. Drugs closely related to probucol that contain the protective...

Rice University researchers create 'nanorice'

...Ph.D., found that alterations in the production of heme (a molecule that contains iron) may be the key to ...that Alzheimer's patients have abnormal amounts of heme in their brains. In new research results, Atamna's team showed that amyloid-beta readily binds with ...

Alzheimer's study first to explain death of brain cells

...Ph.D., found that alterations in the production of heme (a molecule that contains iron) may be the key to ...that Alzheimer's patients have abnormal amounts of heme in their brains. In new research results, Atamna's team showed that amyloid-beta readily binds with ...

Scientists characterize proteome of human cornea

...d were proteins involved in antimicrobial defense, heme and iron transport, tissue protection against UV-radiation and oxidative stress. Several other proteins were known antiangiogenic factors, which prevent the formation of blood vessels. The results from this research may open the door to future thera...

Attacks of King George III's madness linked to key metabolism molecule

...ure of heme. A reddish pigment that contains iron, heme is a building block of the oxygen-carrying hemoglo... in porphyria, since PGC-1 alpha is a regulator of heme manufacture in the liver. One of its actions is controlling the activity of the ALAS-1 gene that mak...

Discoveries by UAB and Florida scientists may help transplanted organs survive longer

... the group found that IL-10 was active through the heme oxygenase-dependent (HO-1) biological pathway between cells. "We found that one dose of IL-10 delivered using a viral vector delays the vascular disease from occurring," Agarwal said. "If the HO-1 pathway is blocked, the protective effects of IL-10 ...

Disease diagnosis, biodefense among UH chemical research projects

...opy of nitrophorins." Nitrophorins are a family of heme proteins found in certain insects that store nitric oxide (NO). Having importance in many areas of human health, NO is useful in lowering blood pressure, treating cancer and increasing oxygen absorption in lung tissue. Czernuszewicz's research is foc...

A bacterial genome reveals new targets to combat infectious disease

...ence in the bacterium of the synthetic pathway for heme - the oxygen-carrying iron component of hemoglobin. The nematode may require heme for synthesis of developmental hormones, so Wolbachia's heme pathway may be an inviting target for t...

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