Scientists pinpoint inflammation gene
...identified SEPS1 as a type of "garbage truck" that helps clear cells of misfolded proteins that build up when cells are placed under stress, Blangero said. Inflammation develops when those faulty proteins accumulate in a cell. People with a genetic variation that impairs SEPS1' ability to purify the cell...Penn study finds direct role for glial cells in brain cross-talk
... could not be transmitted across the synapse. This helps explain why high adenosine levels can suppress epileptic seizures. In contrast, low levels of adenosine increased the transmission of nerve impulses. The modulation of neuronal activity through the regulation of the level of adenosine in the synap...Synthetic Protein Eases Arthritis Symptoms in Mice
...ptors, TNFR-1 and TNFR-2. Naturally occurring PLAD helps both forms of TNFR assemble and prepare to receive TNF-alpha. Synthetic PLAD, the scientists hypothesized, would bind to its natural counterpart and prevent it from performing its usual task. The scientists used a variety of techniques (including in...Looking for the genes that affect a person's level of response to alcohol
... to show that the corollary of this gene in humans helps to control the intensity of the effects of alcohol on the flow of potassium in and out of cells." "We know that alcoholism/alcohol dependence is a complex trait, and that the risk for it is composed of many, many different genes, each contributing ...Gene increases risk of tuberculosis
...ted but remained healthy. MCP-1 is a protein that helps attract immune cells to sites of infection. For this reason, this protein is important during the early immune response to TB-causing bacteria. But extremely high levels of MCP-1 can be dangerous, as they inhibit the production of another immune pr...Researchers show key protein necessary for normal development of red blood cells
...lobin mRNA is a key player in gene expression that helps translate the DNA's genetic code. Lloyd and her colleagues identified that the role of KLF2 for the embryonic epsilon-globin genes is analogous to that of a protein called EKLF. EKLF plays a central role in the developmental regulation of the adult ...Tuberculosis still a risk for patients receiving HIV drugs
...y reduces the viral load of HIV, but it also often helps to keep other infections such as TB under control. In fact, previous studies indicate that HAART can reduce the risk of TB in HIV patients by 70 to 90 percent. Although HIV-infected people living in industrialized nations are at lower risk of TB than...Bats use touch receptors on wings to fly, catch prey, study finds
...ter, more accurate nocturnal hunters. Echolocation helps bats detect their surroundings, while the touch-sensitive receptors help them maintain their flight path and snag their prey. Touch receptors take the form of tiny bumps, or raised domes, along the surface of bats' wings. The domes contain Merkel ce...What can change in the brain? Electrical synapses, research shows
...ccur while you are awake or sleeping. So this work helps us better understand, in a basic sense, how the brain regulates behavioral states." Carole Landisman, currently a neurobiology researcher at Harvard Medical School, is the lead author of the paper. Landisman was an investigator in Connors' lab at Br...One small step means giant leap for spinal cord research
... the muscles of patients with spinal cord injuries helps to increase walking function in those whose condition is not expected to improve. U of T researchers have found that functional electrical stimulation (FES), a process that sends controlled bursts of electricity through the skin and into muscles, c...Mouse study: New muscle-building agent beats all previous ones
...effect lasts after injections cease and whether it helps a mouse model of muscular dystrophy retain enough muscle strength to prolong life. ...Superconducting magnet attracts molecular research
...in structural biology for decades, and this magnet helps keep us at the cutting edge of research," said Pochapsky. "It's an investment in the future." ...MicroRNA may have fail-safe role in limb development
...uspected to be part of an intricate mechanism that helps repress about one-third of our 25,000 genes. It has been linked to diabetes, hepatitis C, leukemia, lymphoma and breast cancer. But only now have microRNAs been connected to actual growth processes. "We found miR 196 expressed only in the hindlimbs...Hot-spring bacteria flip a metabolic switch
...ithin a single cell at high temperatures, and also helps answer longstanding questions about how hot-spring microbial communities get essential nitrogen compounds. Carnegie's Arthur Grossman, Devaki Bhaya, and Anne-Soisig Steunou, along with colleagues from four partner institutions*, are studying the tin...HIV accessory protein disables host immunity via receptor-protein intermediary
...ticoid receptor (GR) pathway of the host cell. Vpr helps to usurp host-cell function by regulating cell differentiation, cell death, and suppressing host-cell immune response proteins. Weiner's group found that Vpr binds to the glucocorticoid receptor, but it remained unclear whether the GR pathway was req...Free HIV tests cheaper than charging when goal is preventing AIDS
...vention is also important, and HIV testing clearly helps to avert HIV infections," Thielman said. "For every $92 invested in free HIV testing and counseling at an organization such as KIWAKKUKI, an HIV infection can be averted," he said. Research has shown that HIV testing and counseling reduces high-ris...... more about this kind of brain activity and how it helps long-term memory." ...Researchers unlock how cells determine their functions
...s produced by and retained at the TREs of Ubx, and helps activate the expression of the Ubx gene by attracting Ash1 to the TREs. The transgenic transcription of non-coding TRE RNA can change the type and function of cells. "As a result, we can now use non-coding RNAs as tools to actively determine cell fa...Plants give pests sock in the gut
A novel enzyme in corn helps the plants defend themselves from voracious caterp...s and is vital for nutrient utilization because it helps the flow of nutrients into the food gut. The researchers tested the permeability of the matrix usi......uffer," he said. "For one, we think that aromatase helps to maintain bone tissue throughout the postmenopausal period. Current aromatase inhibitors may disturb normal bone production ?there is some suggestion that these drugs may increase the risk of fractures." The study's results suggest that nimesulide...