A new way to share models of biological systems
...o identify precisely the components of models, and helps them to retrieve appropriate models, which they can then visualize and build upon using any SBML-compatible software. "Ultimately," says Le Novère, "we hope that publishers will encourage any author who plans to publish a new model to submit it to t...To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists
... bacterium Escherichia coli promotes mutations and helps the pathogen evolve resistance to antibiotics. The scientists also show that E. coli evolution could be halted in its tracks by subjecting the bacteria to compounds that block LexA. Interfering with this protein renders the bacteria unable to evolve ...Newly Discovered 'Branding' Process Helps Immune System Cells Pick Their Fights
...une system cells known as antigen-presenting cells helps T cells determine what to attack. They do this by displaying fragments of proteins they have picked up on their surfaces for inspection by T cells. Fragments of proteins are called peptides. Researchers also knew that when antigen-presenting cells a...Future diabetes drugs may target new protein interaction
...t at this point, knowing for sure whether sirtuin1 helps extend lifespan (an organism issue) or is merely involved in cellular aging (a cell-by-cell issue) in mammals will take much more work. Sirtuin1's potential as a target for treating diabetes is much closer, says Puigserver. The researchers are now p......t at this point, knowing for sure whether sirtuin1 helps extend lifespan (an organism issue) or is merely involved in cellular aging (a cell-by-cell issue) in mammals will take much more work. Sirtuin1's potential as a target for treating diabetes is much closer, says Puigserver. The researchers are now p...Computational verification of protein-protein interactions by orthologous co-expression
...t at this point, knowing for sure whether sirtuin1 helps extend lifespan (an organism issue) or is merely involved in cellular aging (a cell-by-cell issue) in mammals will take much more work. Sirtuin1's potential as a target for treating diabetes is much closer, says Puigserver. The researchers are now p...Eliminate Data Analysis Bottlenecks in Drug Discovery
...t at this point, knowing for sure whether sirtuin1 helps extend lifespan (an organism issue) or is merely involved in cellular aging (a cell-by-cell issue) in mammals will take much more work. Sirtuin1's potential as a target for treating diabetes is much closer, says Puigserver. The researchers are now p...How A Latent Virus Eludes Immune Defenses
...s to a T cell and triggers an immune response—that helps the viral protein evade the killer T cells that co...n of the protein. How this evasive action works or helps the virus in a living organism is not entirely clear. But if T cells aren’t presented with bits of v...Touching Molecules With Your Bare Hands
...s to a T cell and triggers an immune response—that helps the viral protein evade the killer T cells that co...n of the protein. How this evasive action works or helps the virus in a living organism is not entirely clear. But if T cells aren’t presented with bits of v...Ancient immune defense mechanism is no match for HIV-1
...nction as a suppressor of RNA silencing (SRS). Tat helps HIV-1 to elude the cell's natural RNAi defense by ...ns Dr. Jeang. "Our finding that Tat is an SRS also helps explain the long-standing biological observation that when HIV-1 is engineered to be lacking Tat but...While on trail of dioxin, scientists pinpoint cancer target of green tea
...eam found that EGCG binds to HSP90, a protein that helps other proteins stay stable, serving the same role as a tail on a kite. When the two bind, HSP90 no longer turns on the AH receptor, stopping the cascade of events that would lead to the activation of several harmful genes. This weekend Palermo is re...Chemists synthesize molecule that helps body battle cancers, malaria
...s of QS-21A, a medicinally important molecule that helps the body battle disease, has been achieved by chemists at the University of Illinois at Urbana-Champaign. In clinical trials, QS-21A has been shown to significantly improve the body's immune response in vaccine therapies against aggressive diseases ...Pair of cancer genes found to drive both cell migration and division
...n tandem to regulate a molecule called PIP3, which helps the cell decide where to push outward - PI3K makes PIP3 on the membrane on one side of a cell while PTEN breaks it down on the other side. But when both enzymes are missing, levels of PIP3 remain constant throughout the membrane, and the cell can't m...Newly discovered protein an important tool for sleeping sickness research
...scovery of JBP2, a member of a protein family that helps control DNA-related functions, is a significant breakthrough in this quest because Sabatini and his colleagues were able to demonstrate that the protein is the key regulator of base J synthesis. This will provide the scientists a new tool to elucidat...Breakthrough System for Understanding Ocean Plant Life Announced
...scovery of JBP2, a member of a protein family that helps control DNA-related functions, is a significant breakthrough in this quest because Sabatini and his colleagues were able to demonstrate that the protein is the key regulator of base J synthesis. This will provide the scientists a new tool to elucidat...Mice brains shrink during winter, impairing some learning and memory
...e had impaired spatial memory ?the mental map that helps them remember important places in their environment. This is one of the first studies to show seasonal changes in the structure and the functioning of brains of mammals, said Randy Nelson, co-author of the study and professor of psychology and neuro...Vitamin A's paradoxical role in influencing symmetry during embryonic development revealed
...d on the left half." A complex cascade of signals helps generate the three-dimensional body pattern of the zebra fish as well as the human body. Patterning of the body occurs along three main axes: the head to toe, which arranges organs and structures (front, eyes, nose, mouth, jaw, neck, shoulders, etc.)...Cancer drug slows poxvirus in mice
... have been exposed to smallpox virus. "This study helps illuminate the cellular machinery used by poxviruses to exit infected cells, and also provides new support for the concept of treating viral infections by targeting specific host cell molecules rather than the viruses themselves," says NIAID Director...Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
...ses to inject its toxins. LcrV plays two roles. It helps the needle to penetrate the membrane surrounding the target cell. It also suppresses the immune response. LcrV causes affected cells to release 40 times the normal levels of interleukin 10 (IL-10), which dampens down the immune response. LcrV also pr...New study: Sexually transmitted disease treatment can be effectively administered by sex partners
... to their partners," Dr. Kissinger said. And if it helps to prevent the spread and recurrence of STDs, patient-delivered partner treatment could be a valuable tool to add to the physician's black bag. ...